A5077980007- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Tendon Structure and Treatment
- Pregnancy-related medical research
- Trauma and Emergency Care Studies
- Mesenchymal stem cell research
- Management of metastatic bone disease
- Scoliosis diagnosis and treatment
- Hip and Femur Fractures
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Surgical Sutures and Adhesives
- Spinal Hematomas and Complications
- Winter Sports Injuries and Performance
- Radiation Dose and Imaging
- Sports injuries and prevention
- Osteoarthritis Treatment and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Cord Injury Research
- Injury Epidemiology and Prevention
- Tissue Engineering and Regenerative Medicine
Klinik Sonnenhof
2012-2025
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Stiftung Lindenhof Bern
2024
University of Pennsylvania
2018-2024
AO Foundation
2004-2023
Berufsgenossenschaftliche Unfallklinik Frankfurt am Main
2023
Tokai University
2018-2023
Financial Research (Hungary)
2020
John Wiley & Sons (United States)
2019
In Brief Study Design. Intervertebral disc degeneration was evaluated by morphologic appearance, magnetic resonance imaging, and biochemical matrix composition. Caliber distribution of openings the adjacent vertebral osseous endplates were measured. Objectives. Correlation between occlusion endplate intervertebral quantified. Summary Background Data. Calcifications with disease age have suggested insufficient nutrition as a mechanism for degeneration. It has been proposed that openings,...
This is a European cohort study on predictors of spinal injury in adult (≥16 years) major trauma patients, using prospectively collected data the Trauma Audit and Research Network from 1988 to 2009. Predictors for fractures/dislocations or cord were determined univariate multivariate logistic regression analysis. 250,584 patients analysed. 24,000 (9.6%) sustained alone 4,489 (1.8%) with without fractures/dislocations. Spinal had median age 44.5 years (IQR = 28.8-64.0) Injury Severity Score 9...
BACKGROUND: Patients with cervical spine injuries are a high-risk group, the highest reported early mortality rate in spinal trauma. METHODS: This cohort study investigated predictors for injury adult (≥ 16 years) major trauma patients using prospectively collected data of Trauma Audit and Research Network from 1988 to 2009. Univariate multivariate logistic regression analyses were used determine fractures/dislocations or cord injury. RESULTS: A total 250,584 analyzed. Median age was 47.2...
This is a retrospective cohort study.This study aims to determine the proportional incidence, clinical characteristics, treatment patterns with complications and changes in of vertebral fractures over 10 years at Swiss university hospital.A was performed. All patients an acute fracture were included this study. The extracted anonymized data from medical records manually assessed. Demographic data, exact location, etiology, type related obtained.Of 330,225 treated patients, 4772 presented...
Cohort Study. End-stage degenerative segments above fusion levels have been associated with lower rates for surgical adjacent segment disease. We aimed to explore how this degeneration translates into patient reported outcomes. A consecutive series of lumbar patients pathologies were enrolled. Preoperative cranial status was determined using the Combined Imaging Score (CIS). Based on CIS, trichotomized mild (CIS <7), advanced 7-10), and end-stage >10) tertiles. In analysis, tertiles adjusted...
Classification of Intervertebral Disk Degeneration with Axial T2 MappingAtsuya Watanabe1 2 3, Lorin M. Benneker4, Chris Boesch1, Tomoko Watanabe5, Takayuki Obata6 and Suzanne E. Anderson2Audio Available | Share
In Brief Study Design. Homing of human bone marrow–derived mesenchymal stem cells (BMSCs) was studied using ex vivo cultured bovine caudal intervertebral discs (IVDs). Objective. To investigate in a whole organ culture whether metabolic and mechanical challenges can induce BMSC recruitment into the IVD. Summary Background Data. Cells from injured tissues release cytokines mediators that enable progenitor cells. BMSCs have ability to survive within Methods. Bovine IVDs with or without...
Articular cartilage injuries and degeneration affect a large proportion of the population in developed countries world wide. Stem cells can be differentiated into chondrocytes by adding transforming growth factor-β1 dexamethasone to pellet culture, which are unfeasible for tissue engineering purposes. We attempted achieve stable chondrogenesis without any requirement exogenous factors. Human mesenchymal stem were transduced with an adenoviral vector containing SRY-related HMG-box gene 9...
Abstract Background Mesenchymal stromal cells (MSCs) have been introduced as promising cell source for regenerative medicine. Besides their multilineage differentiation capacity, MSCs release a wide spectrum of bioactive factors. This secretome holds immunomodulatory and capacities. In intervertebral disc (IVD) cells, application MSC has shown to decrease the apoptosis rate, induce proliferation, promote production extracellular matrix (ECM). For clinical translation secretome-based...
Several classification systems exist for sacral fractures; however, these are primarily descriptive, not uniformly used, have been validated, and associated with a treatment algorithm or prognosis. The goal of the present study was to demonstrate reliability AOSpine Sacral Classification System among group international spine trauma surgeons.A total 38 fractures were reviewed independently by 18 surgeons selected from an expert panel AOTrauma members. Each case graded each surgeon on 2...
Study Design This paper presents a description of conceptual framework and methodology that is applicable to the manuscripts comprise this focus issue. Objectives Our goal present which relied upon better understand processes through surgeons make therapeutic decisions around how treat thoracolumbar burst fractures (TL) fractures. Methods We will describe used in AO Spine TL A3/4 prospective observational study radiographs collected for were utilized relationships between various variables...
Lumbopelvic distraction stabilization with (triangular osteosynthesis) or without additional iliosacral screw allows anatomic reduction of the posterior pelvic ring after severely displaced sacral fractures, correction resection osteotomies malunions, respectively, septic sacroiliitis and permits early weight bearing. However, this technique is complicated by wound necrosis infection in up to 20% 30%. We describe our experience a less invasive technique.The presented was performed...
Notochordal cells (NC) remain in the focus of research for regenerative therapy degenerated intervertebral disc (IVD) due to their progenitor status. Recent findings suggested action on more mature cells, presumably by secretion specific factors, which has been described as notochordal cell conditioned medium (NCCM). The aim this study was determine NC culture conditions (2D/3D, fetal calf serum, oxygen level) that lead significant IVD activation an indirect co-culture system under normoxia...