This is a retrospective cohort study.This study aims to determine the proportional incidence, clinical characteristics, treatment patterns with complications and changes in of vertebral fractures over 10 years at Swiss university hospital.A was performed. All patients an acute fracture were included this study. The extracted anonymized data from medical records manually assessed. Demographic data, exact location, etiology, type related obtained.Of 330,225 treated patients, 4772 presented...

Recently, a dysregulation of the Hippo-YAP/TAZ pathway has been correlated with intervertebral disc (IVD) degeneration (IDD), as it plays key role in cell survival, tissue regeneration, and mechanical stress. We aimed to investigate influence different loading regimes, i.e., under compression torsion, on induction progression IDD its association pathway. Therefore, bovine IVDs were assigned one four static or complex dynamic regimes: (i) static, (ii) "low-stress", (iii)...

Abstract Purpose The aim of this study was to assess safety and efficacy vertebral body stenting (VBS) by analyzing (1) radiographic outcome, (2) clinical (3) perioperative complications in patients with compression fractures treated VBS at minimum 6-month follow-up. Methods In retrospective cohort study, 78 (61 ± 14 [21–90] years; 67% female) who have received a stent due traumatic, osteoporotic or metastatic thoracolumbar fracture our hospital between 2012 2020 were included. Median...

Abstract Introduction: Low back pain (LBP) is a significant cause of disability in many countries, affecting more than half billion people worldwide. In the past, progenitor cells have been found within nucleus pulposus (NP) human intervertebral disc (IVD). However, context cell therapy, little known about effect cryopreservation and expansion on here called “heterogenic” NP (hNPCs), whether commercially available media are efficient “commonly used” terms viability. Materials: this study,...

The present study aimed (1) to analyze the relative paraspinal autochthonous intramuscular fat volume before and after radiofrequency neurotomy (RFN) (2) compare it contralateral non-treated side.Retrospective cohort study.Inselspital, University Hospital Bern, of Bern.Twenty patients (59.60 ± 8.49 years; 55% female) with chronic low back pain, treated RFN (L2/3-L5/S1) due symptomatic facet joint syndrome (FCS) between 2008 2017 were included.All received a magnetic resonance imaging (MRI)...

Bone morphogenic protein 2 (BMP2) is known to induce osteogenesis and applied clinically enhance spinal fusion despite adverse effects. BMP2 needs be used in high doses effective due the presence of inhibitors. L51P a analogue that acts by inhibition Here, we hypothesized mixtures could achieve better outcomes regarding ossification. To test whether both cytokines are sufficient improve ossification, 45 elderly Wistar rats (of which 21 were males) assigned seven experimental groups, all...

The rat model is a common for intervertebral disc (IVD) and spinal research. However, complications remain challenging. Standard Operating Procedures (SOPs) are validated methods to minimize improve safety quality of studies. SOP fusion surgery has been missing until now. Therefore, the aim study was develop tail in elderly Wistar rats (419.04 ± 54.84 g). An initial preoperative, intraoperative, postoperative surgical setup, including specific anaesthesia pain management protocols,...

Increasing evidence implicates intervertebral disc (IVD) degeneration as a major contributor to low back pain. In addition series of pathogenic processes, degenerated IVDs become vascularized in contrast healthy IVDs. this context, angiopoietin (Ang) plays crucial role and is involved cytokine recruitment, anabolic catabolic reactions within the extracellular matrix (ECM). Over last decade, progenitor cell population has been described nucleus pulposus (NP) IVD be positive for Tie2 marker...

Study Design A single-center validation study. Objective To translate and cross-culturally adapt the AO Spine PROST (Patient Reported Outcome Trauma) into German, to test its psychometric properties among German-speaking Swiss spine trauma patients. Methods Patients were recruited from a level-1 center. Next PROST, EQ-5D-3L questionnaire was used for concurrent validity. Questionnaires filled out at two-time points test-retest reliability. Patient characteristics analyzed using descriptive...

Bone morphogenic protein 2 (BMP2) is known to induce osteogenesis and applied clinically enhance spinal fusion at the cost of adverse effects. BMP2 needs be used in high doses effective. This has been attributed presence inhibitors. L51P a analogue that acts by inhibition Here, we hypothesised mixtures could achieve better outcomes concerning ossification. To test this hypothesis, 45 elderly Wistar rats (21♂) were assigned seven experimental groups, all receiving surgery, including...

This study aimed to evaluate the safety and efficacy of a novel Poly-Ether-Ether-Ketone (PEEK) expandable vertebral body replacement (VBR) for anterior cervico-thoracic column reconstruction in patients with metastatic, traumatic, or degenerative diseases. Radiographic clinical outcomes, as well complication rates, were analyzed retrospective analysis 28 (61 ± 13 years; 64% female) who underwent an cervical corpectomy fusion (ACCF) Expandable Corpectomy Device (ECD) from DePuy/Synthes...

(1) Background: Low back pain (LBP) is often associated with intervertebral disc degeneration (IVDD). Autochthonous progenitor cells isolated from the center, i.e., nucleus pulposus, of IVD (so-called pulposus (NPPCs)) could be a future cell source for therapy. The NPPCs were also identified to positive angiopoietin-1 receptor (Tie2). Similar hematopoietic stem cells, Tie2 might involved in peroxisome proliferator-activated delta (PPARδ) agonist-induced self-renewal regulation. purpose this...

Diffuse idiopathic skeletal hyperostosis (DISH) is characterised by ectopic ossification along the anterior spine and outer intervertebral discs (IVD). However, centre of IVD, i.e., nucleus pulposus, always remains unaffected, which could be due to inhibition bone morphogenetic protein (BMP) pathway. In this study, we investigated transcriptome for BMP pathway DISH-IVD cells versus disc traumatic or degenerative discs. The originated from pulposus (NP), annulus fibrosus (AF) cartilaginous...

An atypical course of the vertebral artery can be medically relevant in displaced Hangman fractures, especially if runs within fracture gap C2 isthmus. During surgical reduction, occluded inside fracture, potentially leading to ischemic conditions brain. The aim this study was report two cases according CARE (case reporting) guidelines, which intraoperative color-coded duplex-ultrasound performed secure safe reduction hangman fractures patients with an artery. Two (Effendi-Levine type II)...