A5080248806- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
Helmholtz Centre for Infection Research
2021-2022
German Center for Infection Research
2022
Abstract SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to vaccine-induced protection against infection. The novel variant of concern (VoC) Omicron BA.1 and its sub-lineages have the largest number amino acid alterations in Spike protein date. Thus, they may efficiently recognition by neutralizing antibodies, allowing breakthrough infections convalescent vaccinated individuals particular those who only received primary immunization scheme. We analyzed...
Recent increases in SARS-CoV-2 infections have led to questions about duration and quality of vaccine-induced immune protection. While numerous studies been published on responses triggered by vaccination, these often focus studying the impact one or two immunisation schemes within subpopulations such as immunocompromised individuals healthcare workers. To provide information against SARS-CoV-2, we analyzed antibody titres various antigens ACE2 binding inhibition wild-type variants concern...
Abstract SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to vaccine-induced protection. The novel variant of concern (VoC) Omicron (B.1.1.529) has the largest number amino acid alterations in its Spike protein date. Thus, it may efficiently recognition by neutralizing antibodies, allowing breakthrough infections convalescent and vaccinated individuals. We analyzed neutralization activity sera from individuals after vaccination with all mRNA-, vector- or...
Abstract Background While SARS-CoV-2 vaccinations were successful in decreasing COVID-19 caseloads, recent increases infections have led to questions about duration and quality of the subsequent immune response. numerous studies been published on responses triggered by vaccination, these often focused initial peak response generated specific population subgroups (e.g. healthcare workers or immunocompromised individuals) only examined effects one two different immunisation schemes. Methods...
Lyme borreliosis is the leading tick-related illness in Europe, caused by Borrelia Burgdorferi s.l. Lower Saxony, Germany, including its capital, Hanover, has a higher proportion of infected ticks than central European countries, justifying research focus on potential human consequences. The current knowledge gap incident infections, particularly Western demands serological insights, especially regarding potentially changing climate-related tick abundance and activity. We determined...