A5033027561- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- 3D Printing in Biomedical Research
- Long-Term Effects of COVID-19
- Neuroscience and Neural Engineering
- SARS-CoV-2 detection and testing
- Receptor Mechanisms and Signaling
- Viral Infections and Vectors
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Innovative Microfluidic and Catalytic Techniques Innovation
Natural and Medical Sciences Institute
2022-2025
University of Tübingen
2022-2024
Max Planck Institute for Dynamics of Complex Technical Systems
2023
Abstract SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to vaccine-induced protection against infection. The novel variant of concern (VoC) Omicron BA.1 and its sub-lineages have the largest number amino acid alterations in Spike protein date. Thus, they may efficiently recognition by neutralizing antibodies, allowing breakthrough infections convalescent vaccinated individuals particular those who only received primary immunization scheme. We analyzed...
New broadly acting and readily available antiviral agents are needed to combat existing emerging viruses. Defective interfering particles (DIPs) of influenza A virus (IAV) regarded as promising options for the prevention treatment IAV infections. Interestingly, DIPs also inhibit unrelated viral infections by stimulating innate immunity. Here, we tested ability suppress respiratory syncytial, yellow fever Zika in vitro. In human lung (A549) cells, DIP co-infection inhibited replication spread...
In the past decades, vaccine development has made great strides. Nevertheless, more often than not, candidates fail in advanced stages of and clinical trials. A key reason is poor predictive value non-clinical vivo vitro models, due to either species-specific differences immune response or insufficient reflection physiological mechanisms. Reliable modeling human adaptive responses a prerequisite understand processes leading vaccine-induced protective immunization drive informed decisions...
Accurate and precise point-of-care (POC) testing for C-reactive protein (CRP) can help support healthcare providers in the clinical management of patients. Here, we compared analytical performance 17 commercially available POC CRP tests to enable more decentralized use tool. The following were evaluated. Eight quantitative tests: QuikRead go (Aidian), INCLIX (Sugentech), Spinit (Biosurfit), LS4000 (Lansionbio), GS 1200 (Gensure Biotech), Standard F200 (SD Biosensor), Epithod 616 (DxGen),...
The rapid emergence of the Omicron variant and its large number mutations led to classification as a concern (VOC) by World Health Organization. Subsequently, evolved into distinct sublineages (eg, BA.1 BA.2), which currently represent majority global infections. Initial studies neutralizing response toward in convalescent vaccinated individuals showed substantial reduction.We assessed antibody (immunoglobulin G [IgG]) binding, ACE2 (angiotensin-converting enzyme 2) binding inhibition, IgG...
COVID-19 convalescent plasma (CCP) with high neutralizing antibodies has been suggested in preventing disease progression COVID-19. In this study, we investigated the relationship between clinical donor characteristics and anti-SARS-CoV-2 CCP donors. donors were included into study. Clinical parameters recorded antibody levels (Spike Trimer, Receptor Binding Domain (RBD), S1, S2 nucleocapsid protein) as well ACE2 binding inhibition measured. An < 20% was defined an inadequate...
Abstract Background Although anti-SARS-CoV-2 humoral immune responses and epidemiology have been extensively studied, data gaps remain for certain populations such as indigenous people or children especially in low- middle-income countries. To address this gap, we evaluated SARS-CoV-2 seroprevalence immunity towards the parental B.1 strain, local variants, endemic coronaviruses from Colombia March to April 2021. Methods We performed a cross-sectional study with 80 Bogotá expanded our...
Abstract The rapid emergence of the Omicron variant and its large number mutations has led to classification as a concern (VOC) by WHO(1). Initial studies on neutralizing response towards this within convalescent vaccinated individuals have identified substantial reductions(2-8). However many these sample sets used in were either small, uniform nature, or compared only wild-type (WT) or, at most, few other VOC. Here, we assessed IgG binding, (Angiotensin-Converting Enzyme 2) ACE2 binding...
Abstract Respiratory syncytial virus (RSV) is one of the leading causes severe respiratory disease in infants and adults. RSV exists as two subtypes A B, which co-circulate throughout season, although will usually become dominant. While vaccines monoclonal therapeutic antibodies either are or shortly available, correlates protection remain unclear. For this purpose, we developed an multiplex immunoassay that analyses antibody titers towards post-F, Nucleoprotein, a diverse mix G proteins....
Abstract Purpose Respiratory syncytial virus (RSV) is one of the leading causes severe respiratory disease in infants and adults. While vaccines monoclonal therapeutic antibodies either are or will shortly become available, correlates protection remain unclear. For this purpose, we developed an RSV multiplex immunoassay that analyses antibody titers toward post-F, Nucleoprotein, a diverse mix G proteins. Methods A bead-based was developed, technically validated to standard FDA bioanalytical...
Respiratory Syncytial Virus (RSV) is one of the leading causes morbidity and mortality among infants adult risk groups worldwide. Substantial case-underdetection gaps in understanding reinfection dynamics RSV limit reliable projection estimates. Here, we use a novel multiplex serological assay population-based panel to estimate season age-specific probability combine it with sentinel notification data parameterize mathematical model tailored project Germany from 2020 2023. Our estimates,...
Abstract Accurate and precise point-of-care (POC) testing for C-reactive protein (CRP) can help support healthcare providers in the clinical management of patients. Here, we compared analytical performance 17 commercially available POC CRP tests to enable more decentralized use tool. The following were evaluated. Eight quantitative tests: QuikRead go (Aidian), INCLIX (Sugentech), Spinit (Biosurfit), LS4000 (Lansionbio), GS 1200 (Gensure Biotech), Standard F200 (SD Biosensor), Epithod 616...