A5033340505- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Zoonotic diseases and public health
- Animal Virus Infections Studies
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Pharmaceutical and Antibiotic Environmental Impacts
- Veterinary medicine and infectious diseases
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Virus-based gene therapy research
- Urinary Tract Infections Management
- Animal Disease Management and Epidemiology
- Neonatal and Maternal Infections
- Family and Patient Care in Intensive Care Units
- Health Systems, Economic Evaluations, Quality of Life
- Berberine and alkaloids research
- Global Security and Public Health
- Bacterial biofilms and quorum sensing
- Streptococcal Infections and Treatments
- Bacteriophages and microbial interactions
- Microbial infections and disease research
University Hospital for Infectious Diseases "Dr Fran Mihaljevic"
2011-2023
University Hospital Centre Zagreb
2012-2023
Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed estimate the burden of infections caused by public concern in countries EU European Economic Area (EEA) 2015, measured number cases, deaths, disability-adjusted life-years (DALYs).We estimated incidence with 16 antibiotic resistance-bacterium combinations from Antimicrobial Resistance Surveillance Network...
As a leading viral cause of acute gastroenteritis in both humans and pigs, rotavirus A (RVA) poses potential public health concern. Although zoonotic spillover porcine RVA strains to is sporadic, it has been detected worldwide. The origin chimeric human–animal closely linked the crucial role mixed genotypes driving reassortment homologous recombination, which play major shaping genetic diversity RVA. To better understand how genetically intertwined human-derived G4P[6] are, present study...
Campylobacteriosis represents a global health challenge due to continuously increasing trends of antimicrobial resistance in
Campylobacteriosis is the most common gastrointestinal bacterial disease in European Union (EU). Wild birds are one of natural reservoirs these pathogens. In this study we tested cloacal swabs 643 gulls captured on rubbish tip Zagreb, Croatia for presence Campylobacter spp. and found 168 positive samples. We used multilocus sequence typing (MLST) to genotype 62 random C. jejuni isolates from gulls, 24 broiler caeca, 27 neck skins 23 human isolates. Altogether, identified 44 different STs,...
Background: Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes with numerous roles in the normal immune response to infection. However, excess MMP activity following infection may lead immunopathological processes that cause tissue damage. Their tissues is subject tight control, which regulated by its specific endogenous inhibitors (TIMPs). It known MMPs bind cell surface proteins (e.g. integrins) and such interactions can have modulatory effects on functionality. The...
In the era of growing antimicrobial resistance, a threat affecting humans, endangering animals, as well livelihoods and food security worldwide, we wanted to find possible explanations for its continuous spread from new perspective. The ubiquity resistance genes requires One Health approach finding AMR spread. natural transformability Campylobacter jejuni, high incidence infections, emerging worldwide inspired us choose C. jejuni ST-21CC be our pathogen analyzing contribution connection...
This study was performed to elucidate genetic relatedness and molecular resistance mechanisms of AmpC-producing multidrug-resistant Proteus mirabilis isolates in University Hospital Split (UHS), define efficient antibiotics vitro. A total 100 nonrepeated, consecutive, amoxicillin/clavulanate- cefoxitin-resistant P. were collected, mostly from urine (44%) skin soft-tissue samples (30%). They all positive cefoxitin Hodge test negative for extended spectrum beta-lactamase production. Pulsed...