A5101943799- Antimicrobial Peptides and Activities
- Wound Healing and Treatments
- Antimicrobial agents and applications
- Malaria Research and Control
- Trypanosoma species research and implications
- HIV/AIDS drug development and treatment
- Silk-based biomaterials and applications
- Protein Hydrolysis and Bioactive Peptides
- Electrospun Nanofibers in Biomedical Applications
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Biochemical and Structural Characterization
- Synthesis of Organic Compounds
- Ionic liquids properties and applications
- Cancer therapeutics and mechanisms
- Chemical Synthesis and Analysis
- Research on Leishmaniasis Studies
- Erythrocyte Function and Pathophysiology
- Venomous Animal Envenomation and Studies
- Shakespeare, Adaptation, and Literary Criticism
- Complement system in diseases
- Pharmacological Effects and Toxicity Studies
- Phytochemical compounds biological activities
- Natural Compound Pharmacology Studies
- Bariatric Surgery and Outcomes
Rede de Química e Tecnologia
2016-2025
Universidade do Porto
2016-2025
Centro Hospitalar Tondela-Viseu
2024
Fairfax Neonatal Associates
2021
University of Aveiro
2015
Surface bioconjugation of antimicrobial peptides (AMP) onto nanoparticles (AMP-NP) is a complex, multistep, and time-consuming task. Herein, microfluidic system for the one-pot production AMP-NP was developed. Norbornene-modified chitosan used NP (NorChit-NP), thiolated-AMP grafted on their surface via thiol–norbornene "photoclick" chemistry over exposure two parallel UV LEDs. The MSI-78A AMP selected due to its high activity against priority (level 2) antibiotic-resistant gastric pathogen:...
Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical antimalarial drugs.
Background/Objectives: Peptides from protein ingredients exhibit key biological activities, including antimicrobial, antihypertensive, antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Aligning with the One Health approach, there is growing investment in promoting pet health well-being. As a result, sustainable functional are increasingly essential for food development. In this work, peptides derived lactoferrins of different mammalian species were synthesized their...
A bioactive hyaluronic acid hydrogel is developed by conjugation of gelatin and antimicrobial peptides.
Plasmodium falciparum, the causative agent of most lethal form malaria, is becoming increasingly resistant to available drugs. A convenient approach combat parasite resistance development analogues classical antimalarial agents, appropriately modified in order restore their relevance chemotherapy. Following this line thought, design, synthesis and vitro evaluation N-cinnamoylated quinacrine surrogates, 9-(N-cinnamoylaminobutyl)-amino-6-chloro-2-methoxyacridines, reported. The compounds were...
A covalent conjugate between an antibacterial ionic liquid and antimicrobial peptide was produced via “click” chemistry, found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, antibiofilm action on a resistant isolate Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is prelude for promise held by liquids -based approaches as tools improve...
Impaired angiogenesis in skin chronic wounds prolongs inflammation and compromises wound healing. Several strategies have been attempted to improve vascularization, such as application of growth factors, like the vascular endothelial factor (VEGF). However, VEGF is expensive, has a short half-life vivo associated tumorigenesis when used high concentrations. QK peptide shorter (15 amino acids), synthetic, VEGF-mimetic with improved stability lower production cost. residence time may be...
Antimicrobial resistance is becoming one the most serious health threats worldwide, as it not only hampers effective treatment of infectious diseases using current antibiotics, but also dramatically increases risks medical procedures like surgery, transplantation, bone and dental implantation, chemotherapy, or chronic wound management. To date, there are no measures to tackle life-threatening nosocomial infections caused by multidrug resistant bacterial species, which Gram-negative species...
Abstract One of the earliest synthetic antimalarial drugs, quinacrine, was recently reported as interesting for treatment acute myeloid leukemia. Inspired by this and similar findings, we evaluated a set quinacrine analogues against gastric (MKN‐28), colon (Caco‐2), breast (MFC‐7) cancer cell lines one normal human fibroblast line (HFF‐1). All compounds, previously developed us dual‐stage leads, displayed antiproliferative activity, stood out selective toward line, MKN‐28. Interestingly,...
Abstract In a follow‐up study to our reports of N‐cinnamoylated chloroquine and quinacrine analogues as promising dual‐stage antimalarial leads with high in vitro potency against both blood‐stage Plasmodium falciparum liver‐stage berghei , we decided investigate the effect replacing cinnamoyl moiety other acyl groups. Thus, series N‐acylated were synthesized, their activities blood‐ spp. assessed along cytotoxicities. Although new found be somewhat less active more cytotoxic than...
Efficient antibiotics are being exhausted, which compromises the treatment of infections, including complicated skin and structure infections (cSSTI) often associated with multidrug resistant (MDR) bacteria, methicillin-resistant S. aureus (MRSA) most prevalent. Antimicrobial peptides (AMP) increasingly regarded as new hope for post-antibiotic era. Thus, future management cSSTI may include use that, on one hand, behave AMP and, other, able to promote fast correct rebuilding. As such, we...
The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds PcP holds promise treatment this opportunistic infection.