A5020871998- Sirtuins and Resveratrol in Medicine
- Pesticide Residue Analysis and Safety
- Pesticide Exposure and Toxicity
- Advanced biosensing and bioanalysis techniques
- Protein Interaction Studies and Fluorescence Analysis
- Drug Transport and Resistance Mechanisms
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Antibiotic Resistance in Bacteria
- Calcium signaling and nucleotide metabolism
- Pesticide and Herbicide Environmental Studies
- Bioactive Compounds and Antitumor Agents
- Tryptophan and brain disorders
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Pharmacogenetics and Drug Metabolism
- Sesame and Sesamin Research
- Animal Ecology and Behavior Studies
- Paraquat toxicity studies and treatments
- Pharmacological Effects and Assays
- Genomics, phytochemicals, and oxidative stress
- Computational Drug Discovery Methods
Mahidol University
2016-2025
Bangkok University
2020
Lehigh University
2011-2013
Background: An imbalance of free radicals and antioxidant defense systems in physiological processes can result protein/DNA damage, inflammation, cellular apoptosis leading to neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD). Sesamin sesamol, compounds derived from sesame seeds oil, have been reported exert various pharmacological effects, especially activity. However, their molecular mechanisms against the oxidative stress induced by...
Background: Accumulating studies have confirmed that oxidative stress leads to the death of neuronal cells and is associated with progression neurodegenerative diseases, including Alzheimer's disease (AD). Despite compelling evidence, there a drawback use antioxidant approach for AD treatment, partly due limited blood-brain barrier (BBB) permeability. Phytosterol known exhibit BBB penetration exerts various bioactivities such as anticancer effects, displays potential treatment dyslipidemia,...
alpha-Mangostin, a polyphenolic xanthone, is primarily found in the pericarp of mangosteen throughout Southeast Asia and considered as "Queen Fruit" Thailand. Nonetheless, it not clarified how alpha-mangostin protects neuronal cells against oxidative stress.In this study, molecular mechanisms underlying neuroprotective effect defending hydrogen peroxide (H2O2)-induced neurotoxicity was explored.cytotoxicity, reactive oxygen species (ROS) generation, apoptotic cascades, protein expression...
The wide use of pesticides raises concerns on the health risks associated with pesticide exposure. For developing countries, like Thailand, monitoring program (in vegetables and fruits) also maximum residue limits (MRL) regulation have not been entirely implemented. MRL is a product limit, safety limit. concentration (expressed as mg/kg) recommended by Codex Alimentarius Commission to be legally permitted in or food commodities animal feeds (Codex Commission, 2015; European 2015). MRLs are...
Cloxyquin is a potential therapeutic compound possessing various bioactivities, especially antibacterial, antifungal, cardioprotective, and pain relief activities. Herein, the interaction mechanism between cloxyquin bovine serum albumin (BSA) has been elucidated in order to fulfill its pharmacokinetic pharmacodynamic gaps essential for further development as drug. Multi-spectroscopic biophysical model analysis suggested that interacts with BSA via static process by ground-state complex...
Neuronal cell death is a key feature of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Plant polyphenols, namely butein, isoliquiritigenin, scopoletin, have been shown to exhibit various biological activities including anti-inflammatory, antimicrobial, antioxidant activities. Herein, scopoletin were explored for their neuroprotective properties against oxidative stress-induced human dopaminergic SH-SY5Y death. The cells exposed hydrogen peroxide (H2O2) revealed...
Background: Alzheimer’s disease (AD) is the most common cause of dementia in elderly populations. Changes expression Amyloid Precursor Protein (APP)-cleaving enzymes directly affect formation Beta (Aβ) plaques, a neuropathological hallmark AD. Objective: We used peripheral blood from AD patients to investigate genes related APP-processing [(β-site APP-cleaving enzyme 1 (BACE1), presenilin1 (PSEN1), and disintegrin metalloproteinase family 10 (ADAM10) 17 (ADAM17)] epigenetic sirtuin...
Nowadays, a lot of produce (fruits and vegetables) sold in many countries are contaminated with pesticide residues, which cause severe effects on consumer health, such as cancer neurological disorders. Therefore, this study aims to determine whether cooking processes can reduce the residues commonly consumed vegetables (Chinese kale yard long beans) Thailand. For experiments, two were cooked using three different processes: boiling, blanching, stir-frying. After treatments, all control...
Salmonella and Vibrio cholerae are the deadliest foodborne pathogens, requiring effective routine screening for food safety assurance. Hence, a duplex polymerase chain reaction integrated with lateral flow immunoassay (PCR-LFIA) was developed rapid detections of V. to overcome laborious, time-consuming, complicated, costly limitations standard bacterial culture. The PCR-LFIA could simultaneously detect invA lolB targets at lower limits 0.1 1 ng, respectively. Without culture enrichment,...
Novel thiazole sulfonamides revealed capabilities against 6-OHDA-induced neuronal damage via SIRT1 activity. Thus, these neuroprotective could be promising candidates for the further development of effective PD therapy.
A set of 1,4-naphthoquinone (1,4-NQ) derivatives possesses various pharmaceutical activities. Among them, a synthetic 2-(4-methoxyanilino)naphthalene-1,4-dione (MN) is found to be non-cytotoxic the normal MRC-5 cells and prevent neuronal SH-SY5Y cell damage. To explore underlying interaction mechanism MN in circulatory system, silico multi-spectroscopic techniques were employed investigate complex human serum albumin (HSA) MN. The between HSA exhibited static fluorescence with potential...
Oxidative stress has been documented as one of the significant causes neurodegenerative diseases. Therefore, antioxidant therapy for prevention diseases seems to be an interesting strategy in drug discovery. The quinoline-based compound, namely 5-nitro-8-quinolinol (NQ), shown excellent antimicrobial, anticancer, and anti-inflammatory activities. However, its neuroprotective effects precise molecular mechanisms human neuronal cells have not elucidated. In this work, NQ on cell viability...
Abstract 5-Amino-8-hydroxyquinoline (5A8HQ), an amino derivative of 8-hydroxyquinoline, has become a potential anticancer candidate because its promising proteasome inhibitory activity to overcome and yet synergize bortezomib for fighting cancers. Therefore, in this study, physicochemical properties interaction activities with serum protein have extensively been elucidated by both vitro silico approaches fulfill the pharmacokinetic pharmacodynamic gaps. 5A8HQ exhibited drug-likeness...
8-Aminoquinoline (8AQ) derivatives have been reported to antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial antimicrobial agents. Interestingly, all these showed fair Moreover, Cu 2 (8AQ-Cu-5Iu) 5 (8AQ-Cu-5Nu) exerted activities against Gram-negative bacteria including P. shigelloides S. dysenteriae. The results reveal application 8AQ its potential compounds be...