A5040822001- Genetic and rare skin diseases.
- Cancer and Skin Lesions
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Parvovirus B19 Infection Studies
- Hedgehog Signaling Pathway Studies
- Histiocytic Disorders and Treatments
- Hair Growth and Disorders
- Sarcoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- RNA regulation and disease
- Soft tissue tumor case studies
- Tumors and Oncological Cases
- Dermatological and COVID-19 studies
- Medicine and Dermatology Studies History
- Dermatological and Skeletal Disorders
- Neonatal skin health care
- Dupuytren's Contracture and Treatments
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations and Hemangiomas
- Autoimmune and Inflammatory Disorders
- Contact Dermatitis and Allergies
- Fibroblast Growth Factor Research
- Prenatal Screening and Diagnostics
- Wnt/β-catenin signaling in development and cancer
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2005-2023
University of Milan
1996-2022
Ospedale Maggiore
1995-2021
Istituti di Ricovero e Cura a Carattere Scientifico
1996-2009
The clinical features and natural history of juvenile xanthogranuloma (JXG) in 14 children affected by neurofibromatosis 1 (NF1) are reported. Mean follow-up 11 these patients was 4.3 years (range 1-10 years). None the developed hematologic malignancies during this period. onset JXG first 2 life 13 patients. In series, association between six or more café au lait spots than 5 mm diameter a good marker for NF1 few life. Overall did not show any distinguishable from those "classical" JXG.
<h3>Background</h3> The epidermal nevus syndromes include different diseases that have the common feature of mosaicism. One these has been recently identified and named<i>phacomatosis pigmentokeratotica,</i>in analogy to phacomatosis pigmentovascularis. It is characterized by an organoid with sebaceous differentiation, a speckled-lentiginous nevus, other associated anomalies. hypothesized this syndrome caused particular genetic mechanism known as twin-spot phenomenon. <h3>Observations</h3>...
Lichen striatus (LS) is an uncommon dermatosis that generally affects children. The histopathology of LS often shows a polymorphic epidermal reaction process variable lichenoid and spongiotic changes having no specific histopathological criteria or simulating other diseases. In the present study, we have evaluated features 41 biopsy specimens immunohistochemical aspects 10 cases LS. 50% cases, found immunopathological constantly allowing correct diagnosis. 9 was not specific, in clear...
Psoriasis affects children with a considerable burden in early life. Treating pediatric psoriasis is challenging also because of the lack updated specific guidelines. With recent approval several biologics for and ongoing COVID-19 pandemic, management young psoriatic patients facing major changes. A revision treatment recommendations therefore needed. In September 2021, board six Italian dermatologists convened to update recommendations. The issued evidence- consensus-based statements...
Hypohidrotic ectodermal dysplasia (HED) is a severe developmental disorder in which nonallelic genetic heterogeneity has been demonstrated. Even though X-linked and autosomal recessive forms are phenotypically similar, identification of the way transmission mandatory to give reliable counseling family address molecular studies. Complete examination relatives patients with HED carriers partial their families key clarifying intrafamilial transmission.Seven diagnosed as having first-degree were...
Spitz nevus has clinically been described as a dome-shaped usually nonpigmented papular or nodular lesion variable in color from pink to red.To give an exhaustive description of the clinical features large series 247 patients.A retrospective analysis nevi excised 1974 1993 performed. We evaluated following features: age, sex, anatomical location, and histopathologic features; descriptive statistics were calculated relationships among above variables assessed.Most lesions pigmented (71.7%),...
<b><i>Background:</i></b> The central nervous system originates ontogenetically from the ectoderm and therefore numerous neurocutaneous syndromes exist. <b><i>Objective:</i></b> We describe a novel syndrome with characteristic epidermal papules plaques associated mild psychomotor retardation epilepsy good prognosis. <b><i>Methods:</i></b> investigated history, clinical features, laboratory parameters including karyotype,...
Epidermolysis bullosa (EB) pruriginosa is a rare clinical subset of dystrophic EB, characterized by marked itching and presence prurigo-like or lichenoid features. In order to further delineate the phenotype understand pathogenesis this disorder, clinical, histological ultrastructural findings 19-year-old patient presenting typical form EB are described. The prevalence papular itchy lesions, signs scratching paucity blisters at time examination may result in incorrect diagnosis treatment....
A male infant, whose father was affected by psoriasis, first seen in our department at 1 month of life for a “bipolar” seborrheic dermatitis, that resolved without treatment 7 months age. At 15 life, the child returned an eruption erythematous and finely scaling papules disposed linear, band‐like fashion over left part body, involving volar surface arm, leg from inguinal fold to ankle, abdomen thorax, where they assumed typical S‐shaped curve following Blaschko lines. The lesions were not...
Abstract: Medallion-like dermal dendrocyte hamartoma is a rare congenital lesion, comprised of benign proliferation fusiform cells that stain positive for CD34, often factor XIIIa, and negative S100. It has highly characteristic clinical presentation consisting well-circumscribed atrophic wrinkled patch located on the upper trunk or neck remains stable with time. We report case an 11-year-old boy typical medallion-like nape was previously misdiagnosed as neurofibroma basis initial...
We observed ten children with a papular eruption purpuric features during the SARS-CoV-2 pandemic in Northern Italy (May-December 2020). Histological examination showed signs of SARS-CoV-2-related dermatosis. Evidence nucleocapsid viral proteins using (2019-nCoV) antibody revealed cuticular staining deep portion eccrine glands all cases.
ABSTRACT Infantile digital fibromatosis (IDF) is a rare tumour of infancy with typical clinical presentation and characteristic histopathological findings. Despite an alarming appearance, IDF does not cause deep infiltration or metastasis. The traditional approach surgical resection was recently challenged by increasing evidence self regression in months years. We describe the history five patients that were followed our departments for 5
The patients are four unrelated children, one boy and three girls, aged between 3 7 months. All the were born at term, had normal postnatal development, in good general health. Each child presented from birth with a single plantar nodule, 0.5 1.5 cm diameter, bilaterally symmetrically localized on medial side of surface both heels (Fig. 1). nodules skin-colored, covered by epidermis, unattached to underlying tissues, soft elastic consistency, nonpulsatile, nontender touch. They did not...
The outcome of aplasia cutis congenita the scalp, nonmembranous type, in a series 21 Caucasian patients is reported. In all congenital skin defect healed with irregular hypertrophic scar formation.