A5004797821- Traditional Chinese Medicine Analysis
- Medicinal Plants and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Remote Sensing and Land Use
- Plant biochemistry and biosynthesis
- Photosynthetic Processes and Mechanisms
- Computational Drug Discovery Methods
- Plant-based Medicinal Research
- Molecular Biology Techniques and Applications
- Medicinal Plant Pharmacodynamics Research
- Plant-Microbe Interactions and Immunity
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Cholinesterase and Neurodegenerative Diseases
- Ion Channels and Receptors
- MicroRNA in disease regulation
- Pharmacological Effects of Medicinal Plants
- Ginseng Biological Effects and Applications
- Cocoa and Sweet Potato Agronomy
- Mitochondrial Function and Pathology
- Plant Gene Expression Analysis
- Morinda citrifolia extract uses
- Tannin, Tannase and Anticancer Activities
- Forest, Soil, and Plant Ecology in China
- Q Methodology Applications
Guangdong Pharmaceutical University
2018-2025
Huadong Hospital
2025
Fudan University
2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2021
Nanjing Medical University
2015-2021
Wuxi People's Hospital
2020-2021
Infinitus (China)
2017
Abstract Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that sensitive to cell swelling, arachidonic acid and its metabolites, epoxyeicosatrienoic acids, which are associated with cerebral ischemia. The activation of TRPV4 induces cytotoxicity in many types cells, accompanied by an increase the intracellular free calcium concentration. modulates mitogen-activated protein kinase (MAPK) phosphatidyl inositol 3 (PI3K)/ B (Akt) signaling pathways regulate...
Shikonin and its derivatives are the most abundant naphthoquinone pigments formed in species of medicinally economically valuable Boraginaceae. A key step shikonin biosynthetic pathway, namely C-3′′ hydroxylation prenylated phenolic intermediate geranylhydroquinone, is expected to be catalyzed by a cytochrome P450. To identify P450 candidates with transcription profiles similar those genes known involved biosynthesis, we carried out coexpression analysis transcriptome data sets...
This paper analyzed life form, habitats and environmental stresses of medicinal plants algal fungi collected in Chinese Pharmacopoeia(2015). ①It was found that only 0.94% the mainly cultivated field. The most common are divided into two types: those whose natural forest margins/undergrowth(about 42.53%) roadside, hillside, wasteland/sand(about 43.78%). former faces such as weak light, pests diseases; latter often main drought, strong ultraviolet radiation, high temperature, low...
Abstract Postmenopausal osteoporosis (PMOP) is a predominant form of clinical osteoporosis. It has led to significant health and social burdens for older patients. Reestablishing the balance between osteogenic osteoclastic crucial strategy treating PMOP. Curcumin (Cur), naturally derived polyphenolic substance, gained recognition as viable option Despite its potential, use Cur hindered by limited bioavailability presence side effects. Nanoparticles modified with aspartic acid octapeptide...
Abstract Pine needles have been widely used in the development of anti-hypertensive and anti-hyperlipidemic agents health food. However, widespread distribution this tree poses great obstacles to quality control efficacy evaluation. To facilitate effective rational exploitation Masson’s pine ( Pinus massoniana Lamb), as well ensure a medicinal agent, we investigated spatial habitat suitability evaluated optimal ranges ecological factors P. with 280 samples collected from 12 provinces China...
MicroRNA (miR)‑23b‑3p plays an important role in tumor growth, proliferation, invasion and migration pancreatic cancer (PC). However, the function mechanistic of miR‑23b‑3p development PC remains largely unknown. In present study, levels serum patients with were found to be elevated, phosphorylation Janus kinase (JAK)2, PI3K, Akt NF‑κВ upregulated. addition, was induced response interleukin‑6 (IL‑6), which is known involved progression PC. Overexpression miR‑23b‑3p, on other hand,...
Biphenyls are unique phytoalexins de novo synthesized in plants response to pathogen attack. These compounds found Maloideae, a subfamily of the Rosaceae. The anti-microbial activities biphenyls have been reported number studies and they appear represent an important defense strategy against pathogens common such as species Malus, Pyrus, Sorbus, Chaenomeles. Here, cell suspension cultures Sorbus pohuashanensis were established study biphenyl formation after yeast extract (YE) treatment. An...
With the rapid development of comprehensive health industry, demand for Chinese medicinal materials is increasing. There also a growing land cultivation materials.Based on analysis characteristics planting habitats herbs, this paper finds that compared with cultivated environment, wild environment more conducive to improvement quality and stress resistance plants. The eco-planting only way achieve high quality, efficient sustainable production traditional medicine. Therefore, according...
The diagnosis of precancerous lesions or early gastric cancer (EGC) is very important for patient survival. Molecular imaging a visualized method that can easily and precisely diagnose tumors. However, there are currently few studies about molecular EGC. Here, we studied the expression carcinoembryonic antigen related cell adhesion molecule 6 (CEACAM6) in progression GC. Then, regulatory roles CEACAM6 GC cells were investigated. Furthermore, both fluorescent-labeled near infrared...
To select suitable references gene of Polygonum multiflorum for expression analysis in different tissues, five candidate reference genes like Actin,GAPDH,SAND,PP2A,TIP41 were selected from the transcriptome data P. multiflorum, then specific primers designed. The stability tissues was analyzed by Real-time quantitative PCR through avilable methods such as geNorm, NormFinder, BestKeeper, Delta CT and RefFinder, to ensure reliability results. results showed that there significant differences...
Chinese Pharmacopoeia provides nine pesticide Maximum Residual Limits(MRLs) of traditional medicines(TCMs), The number pesticides used in production are far more than those listed pharmacopoeia. lack the standards make it's hard to reflect real situation residues TCMs correctly. paper is aimed analyze data from 7 089 items 140 reports, and judging exceedance rate using MRLs European pharmacopoeia，which widely accepted many countries. results show that：①Pesticide 18 kinds higher MRLs，while...
To explore the diversity of bacterial community structure between different layers agarwood, Hiseq(high-throughput sequencing) was used to analyze samples from agarwood. Our results showed that 1 150 096 optimized sequences and 9 690 OTUs were obtained 15 5 which belonged 28 phyla, 61 classes, 110 orders, 212 families 384 genera. Further analysis revealed normal layer(NL) had lowest species richness smallest number OTUs. And total agarwood layer(AL) NL zero, quite different.At same time,...
The ecological agriculture of traditional Chinese medicine (TCM) is generally acknowledged as the most advanced agricultural mode. However, it's still a doubt whether could be widely applied in TCM agriculture. In this study, we first analyze both differences and relationships between organic agriculture, which suggesting that does not need all inputs After introducing situation from across world, characteristics chemical agricultures. Considered with big challenge caused by pointed out...
Based on the ecological and economic problems in Good Agriculture Practice (GAP) of Chinese material medica, we introduced origin, concept, features operative technology eco-agriculture worldwide, emphasizing its modes different biological levels landscape, ecosystem, community, population, individual gene China. And this basis, analyzed background current situation materia proposed development ideas key tasks, including: (1) Analysis planning production pattern medica national wide. (2)...
The traditional Chinese medicine plant Fallopia multiflora (Thunb.) Harald. contains various pharmacodynamically active glycosides, such as stilbene anthraquinone (AQ) and flavonoid glycosides. Glycosylation is an important reaction in metabolism that generally completed by glycosyltransferase the last step of secondary metabolite biosynthesis pathway, it can improve beneficial properties many natural products. In this study, based on transcriptome data F. multiflora, we cloned two...
Atractylodis Rhizoma(AR) is a traditional Chinese medicinal material for food and medicine, with the functions of eli-minating dampness, strengthening spleen, expelling wind evil dispersing cold. AR contains variety compounds, including sesquiterpenoids, alkynes, triterpenoids, aromatic glycosides, polysaccharides so on. At present, researches on mainly focus volatile components, relatively fewer non-volatile components. Polysaccharide from Rhizoma(ARP) an important basis among components...
Plants have a memory function for the environmental stress they suffered. When are subjected to repeated stress, can quickly and better activate response adaptation mechanism thus realizing long-term stable reproduction. However, most of relevant studies applied crops Arabidopsis thaliana rather than medicinal plants about improvement plant growth status effect on phytoalexin biosynthesis. In this study, yeast extract(YE) was used as an elicitor simulate biotic changes in biomass content...