A5101830584- Antioxidant Activity and Oxidative Stress
- Regulation of Appetite and Obesity
- Hydrogen's biological and therapeutic effects
- SARS-CoV-2 and COVID-19 Research
- Lipid metabolism and disorders
- Microbial Inactivation Methods
- Sleep and Wakefulness Research
- Genetic Associations and Epidemiology
- Biofield Effects and Biophysics
- Mycotoxins in Agriculture and Food
- Electromagnetic Fields and Biological Effects
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Morinda citrifolia extract uses
- Natural Antidiabetic Agents Studies
- Obstructive Sleep Apnea Research
- Carcinogens and Genotoxicity Assessment
- Congenital heart defects research
- Tea Polyphenols and Effects
- Adipose Tissue and Metabolism
- Barrier Structure and Function Studies
- Advanced Proteomics Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 detection and testing
- Water Treatment and Disinfection
Suleyman Demirel University
2022-2025
BioNTech (United States)
2024
Süleyman Demirel University
2021-2024
Uppsala University
2014
Leibniz Research Centre for Working Environment and Human Factors
2014
TU Dortmund University
2014
Objective: Epicatechin (EC) is one of the major components green tea catechins. This study investigated effect amount epicatechin obtained by brewing under optimal conditions against oxidative stress induced hydrogen peroxide (H2O2). Materials and Methods: In peripheral blood mononuclear cells (PBMCs), determined optimum was applied 250 µM H2O2 cell viability MTT test, total antioxidant status (TAS) oxidant (TOS) were biochemical analysis, apoptosis-related Bax, Bcl2, p53 expression analysis...
Obstructive sleep apnea syndrome (OSAS) is influenced by genetic, environmental, and developmental factors, with hereditary risk estimated at around 40%. Increasing evidence suggests that OSAS a low-grade chronic inflammatory disease, though the exact mechanisms remain unclear. NLRP3, key component of inflammasome, plays central role in initiating inflammation. This study investigated impact potential single nucleotide polymorphisms (SNPs) NLRP3 promoter region on plasma levels OSA-related...
In this study, we aimed to determine the phenolic compounds, antibacterial activity of extract from Laurus nobilis leaves, and its possible effect on transforming growth factor-β1 expression level in peripheral blood mononuclear cells.
ABSTRACT Vaccines remain a vital public health tool to reduce the burden of COVID-19. COVID-19 vaccines that are more closely matched circulating SARS-CoV-2 lineages elicit potent and relevant immune responses translate improved real-world vaccine effectiveness. The rise in prevalence Omicron JN.1 lineage, subsequent derivative sublineages such as KP.2 KP.3, coincided with reduced neutralizing activity effectiveness XBB.1.5-adapted vaccines. Here, we characterized biophysical immunologic...
In this study, it was aimed to evaluate the pool water quality, bacterial contamination, genotoxicity and oxidative damage parameters according different disinfection methods in regression swimming pools tourist facilities Antalya, Türkiye March 2019. For purpose disinfected samples erythrocyte solutions lymphocytes were incubated at two hours. At end of incubation, lipid peroxidation by thiobarbituric acid reactive substances method peripheral blood DNA single cell gel electrophoresis assay...
Obezite, genetik, çevresel faktörler ve bunların karmaşık
 etkileşimleri tarafından yönetilen birçok kronik
 hastalık ile ilişkilidir. Genetiğin obeziteye yatkınlıkta
 önemli rol oynadığı riskine %70'e kadar
 katkıda bulunabileceği tahmin edilmektedir. Yapılan
 genetik çalışmalar, genlerin bulunduğunu
 doğrulamıştır. Genlerdeki anomaliler, Bardet-
 Biedl Prader-Willi sendromları gibi obezite ile
 ilişkili bozukluklardan doğrudan sorumludur....
Abstract Claudins are central components of tight junctions that regulate epithelial cell barrier function and polarity. Altered claudin expression patterns have been demonstrated in numerous cancer types lineage-specific claudins proposed as therapy targets. The objective this study was to assess 6 (CLDN6) 18 isoform 2 (CLDN18.2) human non-small lung (NSCLC). Transcript levels were evaluated based on gene microarray data from a fresh-frozen NSCLC tissue cohort (n=196). Protein CLDN6...
ABSTRACTThere is strong scientific evidence that the electric field harmful to life. Exposure an (EF) can cause lung toxicity and respiratory disorders. In addition, has been shown tissue damage through inflammation apoptosis. Juglone (JUG) one of powerful antioxidants with anti-apoptotic anti-inflammatory, various pharmacological properties in biological system. this study, we evaluated efficacy JUG against potential adverse effects on lung. Twenty-four Wistar albino rats were randomly...
Bir gastrik peptit olan grelin ve onun büyüme hormonu salgılatıcı G protein-bağlı reseptörünün glukoz metabolizması enerji homeostazında önemli bir rol oynadığına dair ciddi kanıtlar mevcuttur. Bu nedenle, Tip 2 diyabet için duyarlılık alelleri taşıyan bu genler potansiyel birer aday olarak değerlendirilmektedir. Isparta yöresinden 75 hastası 25 kontrolden oluşan 100 Türk yetişkin bireyin dahil edildiği vaka-kontrol kesitsel ilişkilendirme çalışması yapıldı. Grelin geninde dört promotör...
Amaç Lokal ve sistemik faktörlerin, östrojen reseptörü pozitif meme kanseri riskinde artış olan postmenopozal obez kadınlarda hücrelerinin büyümesini yönlendirdiği gösterilmiştir. Postmenapozal dönemdeki kadınlarda, dolaşımdaki girelin hormonunun azaldığı, bazı tümör hücreleri tarafından üretildiği ayrıca etkilediği Bu çalışmada, adiponektin uygulamasının MCF-7 hücre hattındaki rolünü seviyeleri üzerine etkilerini araştırmayı amaçladık. Gereç Yöntem hattı 2 boyutlu kültürde çoğaltıldı....