A5081725401- Hepatitis C virus research
- Hepatitis B Virus Studies
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Forensic Anthropology and Bioarchaeology Studies
- Agricultural Economics and Practices
- Wheat and Barley Genetics and Pathology
- Research on Leishmaniasis Studies
- Genetics and Plant Breeding
- COVID-19 Clinical Research Studies
- Weed Control and Herbicide Applications
- Hepatitis Viruses Studies and Epidemiology
- Language, Linguistics, Cultural Analysis
- Gait Recognition and Analysis
- Agricultural Research and Practices
- Wound Healing and Treatments
- Climate Change and Health Impacts
- Agriculture, Water, and Health
- Plant and Biological Electrophysiology Studies
- Ergonomics and Musculoskeletal Disorders
Pfizer (United States)
2024
University of Maryland, Baltimore
2015-2023
Walter Reed Army Institute of Research
2021-2023
Shyam Shah Medical College
2022-2023
Council of Scientific and Industrial Research
2023
Academy of Scientific and Innovative Research
2023
Henry M. Jackson Foundation
2021
Government of the United States of America
2021
Pandit Ravishankar Shukla University
2013-2016
Panjab University
2016
The need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) next-generation vaccines has been highlighted by the rise of variants concern (VoCs) and long-term threat emerging coronaviruses. Here, we design characterize four categories engineered nanoparticle immunogens that recapitulate structural antigenic properties prefusion SARS-CoV-2 spike (S), S1, receptor-binding domain (RBD). These induce robust S binding, ACE2 inhibition, authentic pseudovirus neutralizing antibodies...
Abstract The inability of most untreated patients with Kala-azar to control their visceral infections Leishmania donovani has been attributed a defective cell-mediated immune response leishmanial antigens. We examined the in vitro T cells, including Leu-2+-depleted cell populations, determine whether unresponsiveness could be reversed. These studies on leishmaniasis Bihar, north India, support previous observations regarding active disease: it is profound, specific, and reversible after...
Abstract The emergence of variants concern, some with reduced susceptibility to COVID-19 vaccines underscores consideration for the understanding vaccine design that optimizes induction effective cellular and humoral immune responses. We assessed a SARS-CoV-2 spike-ferritin nanoparticle (SpFN) immunogen paired two distinct adjuvants, Alhydrogel ® or Army Liposome Formulation containing QS-21 (ALFQ) unique evoked signatures. Recruitment highly activated multifaceted antigen-presenting cells...
Chronic hepatitis B infection (CHB) is characterized by sub-optimal T cell responses to viral antigens. A therapeutic vaccine capable of restoring these immune could potentially improve HBsAg seroconversion rates in the setting direct acting antiviral therapies. yeast-based immunotherapy (Tarmogen) platform was used make a candidate expressing virus (HBV) X, surface (S), and Core antigens (X-S-Core). Murine human immunogenicity models were evaluate type magnitude HBV-Ag specific elicited...
This study demonstrates the impact of adjuvant on development T follicular helper (Tfh) and B cells, their influence antibody responses in mice vaccinated with SARS-CoV-2-spike-ferritin-nanoparticle (SpFN) adjuvanted either Army Liposome Formulation containing QS-21 (SpFN + ALFQ) or Alhydrogel
Background. Treatment of genotype 1 hepatitis C virus (HCV) infection with combination directly acting antivirals (DAA) for 8–24 weeks is associated high rates sustained virologic response (SVR). We previously demonstrated that adding a third DAA to ledipasvir and sofosbuvir (LDV/SOF) can result in SVR patients without cirrhosis. In this study, we investigated whether similar regimen would yield equivalent cure advanced liver fibrosis.
Summary Hepatitis B Virus ( HBV ) infection in infancy or early childhood leads to high rate of persistent (25–90%). The immunological basis viral persistence vertically acquired infections is not completely understood. CD 8 T cells play a pivotal role clearing the virus adults. Herein, we sought delineate HB sAg+ve newborns . At birth peripheral and cord blood N = 12), sAg‐ve 10) healthy HC : 15) were evaluated for T‐cell frequency functionality by flow cytometry. No significant differences...
Summary Treatment for chronic hepatitis C virus ( HCV ) infection has rapidly evolved into interferon‐free directly acting antiviral regimens DAA that result in high sustained virologic response. s primarily work by suppressing replication and rely less on the immune system than interferon‐based therapies. However, it is unclear whether recovers with suppression of contributes to clearance therapy. We previously demonstrated associated increased ‐specific immunity CHCV ‐ GT ‐1‐infected...
SUMMARY The need for SARS-CoV-2 next-generation vaccines has been highlighted by the rise of variants concern (VoC) and long-term threat other coronaviruses. Here, we designed characterized four categories engineered nanoparticle immunogens that recapitulate structural antigenic properties prefusion Spike (S), S1 RBD. These induced robust S-binding, ACE2-inhibition, authentic pseudovirus neutralizing antibodies against in mice. A Spike-ferritin (SpFN) vaccine elicited titers more than...
Patients coinfected with human immunodeficiency virus (HIV) and hepatitis C (HCV) have higher levels of immune activation, impaired antigen-specific responses, accelerated fibrogenesis compared to patients monoinfected HCV. Whether different direct-acting antiviral (DAA) combinations differential effects on immunophenotypes functions following successful HCV therapy remain unknown. Therefore, we aimed assess the peripheral T-cell in HIV/HCV who were successfully treated combination DAA...
Abstract Potent cellular responses to viral infections are pivotal for long -lived protection. Evidence is growing that these critical in SARS -CoV-2 immunity. Assessment of a spike ferritin nanoparticle (SpFN) immunogen paired with two distinct adjuvants, Alhydrogel® (AH) or Army Liposome Formulation containing QS-21 (ALFQ) demonstrated unique vaccine evoked immune signatures. SpFN+ALFQ enhanced recruitment highly activated classical and non -classical antigen presenting cells (APCs) the...
Abstract The incidences of lightning strikes are not infrequent. electric discharge the strike produces extreme heat and high amperage current, but fatality is reported in only about 10% to 30% cases. spectrum injuries due can vary from no external typical injuries. Merely presence superficial should be considered sufficient dismiss case as non-serious. Rather clinicians wary internal damage effect current well delayed complications which fatal. Similarly, during an autopsy, forensic...
Humoral immune responses are protective against hepatitis B virus (HBV) infection. We characterized B-cell phenotypic changes in infants of surface antigen positive mothers compared with normal and negative at birth 1 year after HBV immunization. Hepatitis had higher immature transitional cells birth, which normalized a Immature response to neonatal exposure is associated maternal-child transmission HBV.
Introduction Fly ash, a by-product from power plants, is powdery gray material that stored in large ash dykes or ponds. This used making bricks and cement factories. considered to be major pollution problem as it dispersed into the air pollutes bodies of water. However, for local tribal populations Korba district, Chhattisgarh state, fly becoming source livelihood. These forest-dwelling groups are leaving their traditional ways life mingling more with mainstream society India. The goal this...
ABSTRACT Shigella causes bacillary dysentery and is responsible for a high burden of disease globally. Several studies have emphasized the value functional antibody activity to understand immunity correlates protection. The anti-microbial function local (mucosal) antibodies their contribution preventing infection remain unknown. goal this study was identify humoral immune effectors elicited by two sonnei live oral vaccine candidates, WRSs2 WRSs3. Complement-dependent bactericidal [serum...
ABSTRACT Vaccines remain a vital public health tool to reduce the burden of COVID-19. COVID-19 vaccines that are more closely matched circulating SARS-CoV-2 lineages elicit potent and relevant immune responses translate improved real-world vaccine effectiveness. The rise in prevalence Omicron JN.1 lineage, subsequent derivative sublineages such as KP.2 KP.3, coincided with reduced neutralizing activity effectiveness XBB.1.5-adapted vaccines. Here, we characterized biophysical immunologic...