A5050588326- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Lower Extremity Biomechanics and Pathologies
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Osteoarthritis Treatment and Mechanisms
- Sports injuries and prevention
- Knee injuries and reconstruction techniques
- Foot and Ankle Surgery
- HIV/AIDS drug development and treatment
- Systemic Lupus Erythematosus Research
- Hair Growth and Disorders
- Chronic Lymphocytic Leukemia Research
- HIV-related health complications and treatments
- Shoulder Injury and Treatment
- Cardiac and Coronary Surgery Techniques
- scientometrics and bibliometrics research
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- interferon and immune responses
- RNA regulation and disease
- Meta-analysis and systematic reviews
Hospital for Special Surgery
2019-2024
University of California, Los Angeles
2021
University of California System
2020
Stanley Medical College
2017
Columbia University
2016
National Institutes of Health Clinical Center
2015
University of Maryland, Baltimore
2015
Medical University of South Carolina
2015
National Institute of Allergy and Infectious Diseases
2015
National Cancer Institute
2015
There is an unmet need for interferon- and ribavirin-free treatment chronic hepatitis C virus (HCV) infection in patients co-infected with human immunodeficiency (HIV).
Background. Hepatitis C virus (HCV) RNA loads serve as predictors of treatment response during interferon-based therapy. We evaluated the predictive ability HCV levels at end (EOT) for sustained virologic (SVR12) interferon-sparing direct-acting antiviral therapies. Methods. genotype 1–infected, treatment-naive patients were treated with sofosbuvir and ribavirin 24 weeks (n = 55), ledipasvir 12 20), sofosbuvir, ledipasvir, GS-9669 6 or GS-9451 19). Measurements performed using Roche COBAS...
As treatment for chronic hepatitis C (HCV) virus has evolved to all-oral, interferon-free directly acting antiviral (DAA) therapy, the impact of these improvements on patient adherence not been described. Medication was measured in 60 HCV, genotype-1, treatment-naïve participants enrolled a phase 2a clinical trial at National Institutes Health and community clinics. Participants received either ledipasvir/sofosbuvir (LDV/SOF) (90 mg/400 mg) (one pill) daily 12 weeks, LDV/SOF + GS-9451 (80...
Treatment of chronic hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) for 6 weeks achieves sustained virologic response (SVR) rates 95% in some patients. If effective, shorter therapeutic courses could improve adherence and treatment costs.
Background. The optimal retreatment strategy for chronic hepatitis C virus (HCV) patients who fail directly-acting antiviral agent (DAA)-based treatment is unknown. In this study, we assessed the efficacy and safety of ledipasvir (LDV) sofosbuvir (SOF) 12 weeks in HCV genotype-1 (GT-1) failed LDV/SOF–containing therapy. Methods. single-center, open-label, phase 2a trial, 34 participants with early-stage liver fibrosis previously 4–6 LDV/SOF GS-9669 and/or GS-9451 received weeks. primary...
Chronic hepatitis C virus (HCV) infection is associated with lower serum concentration of low-density lipoprotein (LDL-C), the primary cholesterol metabolite targeted pharmaceutically to modulate cardiovascular risk. human immunodeficiency (HIV) and treatment antiretrovirals (ARVs) are dyslipidemia increased risk disease. In subjects coinfected HIV HCV, lipid abnormalities either alone often attenuated. Treatment chronic HCV in HIV/HCV-coinfected now possible interferon (IFN)-free regimens...
Osgood-Schlatter disease (OSD) is a traction apophysitis of the tibial tubercle caused by repetitive strain and chronic avulsion from patellar tendon. No widely accepted anatomic risk factors have been associated with OSD.To determine if OSD increased posterior slope (PTS).Cross-sectional study; Level evidence, 3.Forty knees 32 control examined senior author between 2008 2019 were included. Patients 10 to 15 years age clinical diagnosis available lateral radiograph magnetic resonance imaging...
Background. Treatment of genotype 1 hepatitis C virus (HCV) infection with combination directly acting antivirals (DAA) for 8–24 weeks is associated high rates sustained virologic response (SVR). We previously demonstrated that adding a third DAA to ledipasvir and sofosbuvir (LDV/SOF) can result in SVR patients without cirrhosis. In this study, we investigated whether similar regimen would yield equivalent cure advanced liver fibrosis.
Vitamin D deficiency is associated with cognitive impairment in the elderly and increased white matter T2 hyperintensities debilitated patients. We investigated relationship between serum vitamin brain MR findings adult outpatients.Brain studies of 56 patients ages 30-69 years were selected when level had been obtained within 90 days MRI. White characterized by size location two neuroradiologists. Manual volumetric analysis was assessed more than 50 age.The entire cohort showed a significant...
To establish normative values for articular cartilage thickness in pediatric and adolescent knees using magnetic resonance imaging (MRI) investigate any associations with age skeletal maturity.MRI scans were analyzed patients 7 to 18 years old without osteochondral lesions, chondral wear/pathology, intra-articular fractures, or history of knee surgery. Measurements at the patella (medial facet, lateral median ridge), femur condyle, trochlea), tibia plateau, plateau) made on axial, coronal,...
Patellofemoral instability is a common problem affecting children and adolescents, with recurrent often requiring surgical intervention. Medial patellofemoral ligament (MPFL) reconstruction has become mainstay for the treatment of because biomechanical importance MPFL against lateral dislocation as well high frequency injury following traumatic patellar dislocation. The concern in managing skeletally immature patients potential to distal femoral physis. Here, we highlight 2 techniques...
This study examines the distinct gene expression profile of peripheral blood mononuclear cells from patients with chronic hepatitis C (CHC) infection and mixed cryoglobulinemic (MC) vasculitis. Our DNA microarray analysis indicates that HCV-associated MC vasculitis is characterized by compromised neutrophil function, impaired chemotaxis, increased interferon stimulated (ISG) expression, contributing to overall pathogenesis end organ damage. Increased ISG suggestive an enhanced endogenous...
<h3>Purpose</h3> To highlight important diagnostic and treatment considerations in patients who present with bifocal patellar tendon avulsion fractures from the tibial tubercle inferior pole. <h3>Methods</h3> Radiographic presentation, surgical technique, complications of 5 children sustained ≥6 months postoperative follow-up were retrospectively reviewed. Hospital for Special Surgery (HSS) Brief Functional Activity Scale (HSS Pedi-FABS), Patient-Reported Outcomes Measurement Information...
Hepatitis C (HCV) treatment for patients coinfected with human immunodeficiency virus (HIV) and HCV is associated modest rates of sustained virologic response (SVR) an increased rate relapse when compared to monoinfected patients. As who attain SVR are clinically indistinguishable during treatment, where both groups have fully suppressed viral load, it has not been possible identify in advance those will relapse. Biomarkers that may distinguish differential be useful provide insight into...