A5077952699- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- Parvovirus B19 Infection Studies
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
Pfizer (United States)
2023-2025
Pearl River Community College
2023
Respiratory syncytial virus (RSV) is the leading, global cause of serious respiratory disease in infants and an important illness older adults. No RSV vaccine currently available. The fusion (F) glycoprotein a key antigen for development, its prefusion conformation target most potent neutralizing antibodies. Here, we describe computational experimental strategy designing immunogens that enhance conformational stability immunogenicity F. We obtained optimized after screening nearly 400...
ABSTRACT As SARS-CoV-2 continues to evolve, increasing in its potential for greater transmissibility and immune escape, updated vaccines are needed boost adaptive immunity protect against COVID-19 caused by circulating strains. Here, we report features of the monovalent Omicron XBB.1.5-adapted BNT162b2 vaccine, which contains same mRNA backbone as original modified incorporation XBB.1.5-specific sequence changes encoded prefusion-stabilized spike protein (S(P2)). Biophysical characterization...
Abstract As SARS-CoV-2 evolves, increasing in potential for greater transmissibility and immune escape, updated vaccines are needed to boost adaptive immunity protect against COVID-19 caused by circulating strains. Here, we report features of the monovalent Omicron XBB.1.5-adapted BNT162b2 vaccine, which contains XBB.1.5-specific sequence changes, relative original backbone, encoded prefusion-stabilized spike protein (S(P2)). Biophysical characterization XBB.1.5 S(P2) demonstrated that it...
Abstract Herpes zoster (HZ) is a painful vesicular rash that occurs upon varicella-zoster virus (VZV) reactivation in older adults and immunocompromised individuals. Although there currently an approved vaccine for the prevention of shingles, its administration commonly associated with high reactogenicity. This highlights need to develop new alternatives long lasting immunity improved tolerability administration. In present study, 10 different candidate designs using two codon optimizations...
ABSTRACT Vaccines remain a vital public health tool to reduce the burden of COVID-19. COVID-19 vaccines that are more closely matched circulating SARS-CoV-2 lineages elicit potent and relevant immune responses translate improved real-world vaccine effectiveness. The rise in prevalence Omicron JN.1 lineage, subsequent derivative sublineages such as KP.2 KP.3, coincided with reduced neutralizing activity effectiveness XBB.1.5-adapted vaccines. Here, we characterized biophysical immunologic...