A5059528397- Sex work and related issues
- HIV, Drug Use, Sexual Risk
- Substance Abuse Treatment and Outcomes
- Emergency and Acute Care Studies
- Sexuality, Behavior, and Technology
- Homelessness and Social Issues
- HIV/AIDS Research and Interventions
- Neuroscience and Neuropharmacology Research
- Opioid Use Disorder Treatment
- Migration, Health and Trauma
- Ion channel regulation and function
- Intimate Partner and Family Violence
- Healthcare Decision-Making and Restraints
- Food Security and Health in Diverse Populations
- Diversity and Career in Medicine
- Disaster Response and Management
- Receptor Mechanisms and Signaling
- Acute Ischemic Stroke Management
- Prenatal Substance Exposure Effects
- Sexual Assault and Victimization Studies
- Racial and Ethnic Identity Research
- Innovations in Medical Education
- Trauma and Emergency Care Studies
- Simulation-Based Education in Healthcare
- Cultural Competency in Health Care
Massachusetts General Hospital
2016-2025
Harvard University
2014-2024
Promise Project
2022-2024
Brigham and Women's Hospital
2018-2024
Lemuel Shattuck Hospital
2024
Harvard Affiliated Emergency Medicine Residency
2007-2024
University of New Mexico
2023
New York University
2023
National Institute on Drug Abuse
2023
Center for Health and Gender Equity
2023
Sex trafficking, trafficking for the purpose of forced sexual exploitation, is a widespread form human that occurs in all regions world, affects mostly women and girls, has far-reaching health implications. Studies suggest up to 50 % sex victims USA seek medical attention while their situation, yet it unclear how healthcare system responds needs trafficking. To understand intersection public health, we performed in-depth qualitative interviews among 277 antitrafficking stakeholders across...
Medical treatment settings such as emergency departments (EDs) present important opportunities to address problematic substance use. Currently, EDs do not typically intervene beyond acute medical stabilization.
Human trafficking, a form of modern slavery, is an egregious violation human rights with profound personal and public health implications. It includes forced labor sexual exploitation both U.S. non-U.S. citizens has been reported in all 50 states. Victims trafficking are currently among the most abused disenfranchised persons society, they face wide range negative outcomes resulting from their subjugation exploitation. Medicine important role to play mitigating devastating effects on...
Race-based bias in health care occurs at organizational, structural, and clinical levels impacts emergency medical care. Limited literature exists on the role of race patient restraint setting. This study sought to examine physical an department (ED) a major academic center.Retrospective chart analysis was performed, querying all adult ED visits over 2-year period (2016-2018) Massachusetts General Hospital. The associations between selected covariates (sex, insurance, age, diagnosis,...
The second messenger pathways linking receptor activation at the membrane to changes in nucleus are just beginning be unraveled neurons. work presented here attempts identify striatal neurons that mediate cAMP response element-binding protein (CREB) phosphorylation and gene expression NMDA activation. We investigated of transcription factor CREB, immediate early c-fos, induction a transfected reporter under transcriptional control CREB after stimulation ionotropic glutamate receptors. found...
Abstract Addictive drugs such as amphetamine and cocaine stimulate the dopaminergic system, activate dopamine receptors induce gene expression throughout striatum. The signal transduction pathway leading from receptor stimulation at synapse to in nucleus has not been fully elucidated. Here, we present evidence that D1 leads phosphorylation of transcription factor Ca 2+ cyclic AMP response element binding protein (CREB) by means NMDA receptor‐mediated signaling. Stimulation induces Ser897 on...
The present study deals with the functional interaction of antipsychotic drugs and NMDA receptors. We show that both conventional drug haloperidol atypical clozapine mediate gene expression via intracellular regulation receptors, albeit to different extents. Data obtained in primary striatal culture demonstrate intraneuronal signal transduction pathway activated by haloperidol, cAMP pathway, leads phosphorylation NR1 subtype receptor at 897 Ser. Haloperidol treatment is likewise shown...
Abstract Background Research regarding disparities in physical restraint use the emergency department (ED) is limited. We evaluated role of race, ethnicity, and preferred language on application among ED patients held under a Massachusetts section 12(a) order for mandatory psychiatric evaluation. Methods identified all patient encounters with across large integrated 11‐hospital health system from January 2018 through December 2019. Information age, language, insurance, mental illness,...
Objectives: The commercial sexual exploitation of children (CSEC), including sex trafficking minors, is considered a severe form abuse and violence against minors. We use public health lens to examine perceptions regarding the context process CSEC minors in Boston area, response care sector, opportunities improve well-being exploited/trafficked
Human trafficking, also known as modern-day slavery, is an egregious human rights violation associated with wide-ranging medical and mental health consequences. Because of the extensive problems related to care providers play a critical role in identifying survivors engaging them ongoing care. Although guidelines for recognizing affected patients framework developing response protocols settings have been described, survivors' engagement services very challenging. High rates disengagement,...
Human trafficking is associated with a profound burden of physical and psychological trauma. Survivors interact the health care system during after their experiences trafficking. Socioeconomic isolation, stigma, shame, guilt, fear judgment, retribution by traffickers, law enforcement authorities, other factors known to inhibit disclosure can exert formative influence on survivors’ experiences, access, services engagement. Using mixed qualitative-quantitative social science research method,...
Introduction: Emergency clinicians on the frontline of coronavirus pandemic experience a range emotions including anxiety, fear, and grief. Debriefing can help process these emotions, but makes it difficult to create physically psychologically safe space in emergency department (ED) perform this intervention. In response, we piloted video-based debriefing program support clinician well-being. We report details our results evaluation its acceptability perceived value during pandemic.Methods:...
Examining the social risks that influence health of patients accessing emergency care can inform future efforts to improve outcomes. The optimal modality for screening in department (ED) has not yet been identified. We conducted a mixed methods evaluation impact on patient satisfaction with process.
Recent scholarship has revealed racial disparities in emergency department (ED) physical restraint use agitation management. We implemented an interdisciplinary educational program that integrates discussions about the role of bias with workplace violence (WPV) prevention strategies to increase awareness implicit and comfort verbal de-escalation among ED staff. In partnership hospital security at a large urban academic medical center, we developed 1-hour online WPV prerequisite course...
Glutamate carboxypeptidase II (GCP II) catalyzes the extracellular hydrolysis of neuromodulator<i>N</i>-acetyl-aspartylglutamate to<i>N</i>-acetyl-aspartate and glutamate. GCP also hydrolyzes γ-glutamyl bonds in folylpolyglutamate. The predicted amino acid sequence displays similarities to aminopeptidases from<i>Streptomyces griseus</i> <i>Vibrio proteolyticus</i>, whose crystal structures have been determined. These are cocatalytic zinc metallopeptidases belonging peptidase family M28....
It is estimated that 21 million people are trafficked worldwide, including 11.4 women and girls. Approximately 4.5 forced to do sexual labor. The exact prevalence of human trafficking difficult ascertain, however, given the limitations data collection in an illegal industry. Obstetrician–gynecologists should not only be aware widespread nature trafficking, but also have tools assess patients for respond victim identifications. Patients may present with signs physical abuse, depression,...