A5024996382- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Soil Carbon and Nitrogen Dynamics
- Microbial Community Ecology and Physiology
- Horticultural and Viticultural Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Ovarian cancer diagnosis and treatment
- Geology and Paleoclimatology Research
- Clinical practice guidelines implementation
- Musculoskeletal pain and rehabilitation
- Isotope Analysis in Ecology
- Cervical and Thoracic Myelopathy
- Neuroscience and Neuropharmacology Research
- Heavy metals in environment
- Medical Imaging and Analysis
- Cervical Cancer and HPV Research
- Intracranial Aneurysms: Treatment and Complications
- Breast Cancer Treatment Studies
- Marine and coastal ecosystems
- Soil erosion and sediment transport
- Breast Lesions and Carcinomas
- Meningioma and schwannoma management
- Agriculture and Rural Development Research
Virginia Mason Medical Center
2016-2025
Center for Neurosciences
2022-2025
Franciscan Health
2022-2025
Université de Bourgogne
2012-2024
Centre National de la Recherche Scientifique
2003-2024
Biogéosciences
2010-2024
Université de Rennes
2015-2022
Centre Hospitalier Universitaire de Rennes
2007-2022
U.S. Global Leadership Coalition
2022
Seattle University
2016-2022
ABSTRACT In soil, the link between microbial diversity and carbon transformations is challenged by concept of functional redundancy. Here, we hypothesized that redundancy may decrease with increasing source recalcitrance coupling C cycling change accordingly. We manipulated to examine how affects decomposition easily degradable (i.e., allochthonous plant residues) versus recalcitrant autochthonous organic matter) sources. found a in (i) affected both sources, thereby reducing global CO 2...
Amphetamine and cocaine induce the expression of both immediate early genes (IEGs) neuropeptide in rat striatum. Despite demonstrated dependence these effects on D1 dopamine receptors, which activate cyclic AMP pathway, there are several reports that amphetamine cocaine-induced IEG can be inhibited striatum vivo by NMDA receptor antagonists. We find vivo, antagonist MK-801 inhibits induction c-fos acutely also prevents downregulation with chronic administration. Such observations raise...
<i>Background:</i> Innovations in shunt technology and neuroendoscopy have been increasingly applied to management. However, the relative life span of shunts etiology failure not characterized recently. <i>Methods:</i> We reviewed records all shunting procedures at our institution between January 1992 December 1998. Independent predictors were analyzed via multivariate Cox regression analysis 836 procedures. (infection, proximal obstruction, distal malfunction)...
This work is the first report on use of DNA-, RNA-SIP approaches to elucidate dynamics and diversity bacterial populations actively assimilating C derived from plant residues labelled at more than 90% (13)C. Wheat-residues, were incorporated incubated into soil microcosms for 28 days. At end incubation time, no 55% total CO(2) released was (13)C-labelled, suggesting occurrence an important priming effect process. After 7 days, 30% whole DNA extracted labelled, allowing efficient separation...
Summary Despite the central role of microbes in soil processes, empirical evidence concerning effect their diversity on stability remains controversial. Here, we addressed ecological insurance hypothesis by examining microbial communities along a gradient response to mercury pollution and heat stress. Diversity was manipulated dilution extinction approach. Structural functional stabilities were assessed from patterns genetic structure respiration after Dilution led establishment consistent...
The second messenger pathways linking receptor activation at the membrane to changes in nucleus are just beginning be unraveled neurons. work presented here attempts identify striatal neurons that mediate cAMP response element-binding protein (CREB) phosphorylation and gene expression NMDA activation. We investigated of transcription factor CREB, immediate early c-fos, induction a transfected reporter under transcriptional control CREB after stimulation ionotropic glutamate receptors. found...
OBJECTIVE: The purpose of this study was to compare the long-term effectiveness spinal cord stimulation using laminectomy-style electrodes versus that percutaneously implanted electrodes. METHODS: Forty-one patients underwent an initial trial period with temporary at Duke Medical Center between December 1992 and January 1998. A permanent system if reduced patient’s pain by more than 50%. Median follow-up after electrode placement 34 months (range, 6–66 mo). Severity determined...
The present study deals with the functional interaction of antipsychotic drugs and NMDA receptors. We show that both conventional drug haloperidol atypical clozapine mediate gene expression via intracellular regulation receptors, albeit to different extents. Data obtained in primary striatal culture demonstrate intraneuronal signal transduction pathway activated by haloperidol, cAMP pathway, leads phosphorylation NR1 subtype receptor at 897 Ser. Haloperidol treatment is likewise shown...
A review of the literature on acute traumatic retrosternal dislocations clavicle revealed that closed reduction often fails. In six our seven patients retraction shoulders with caudal traction adducted arm, while patient was supported by an interscapular bolster, achieved dislocation. We analyzed mechanism this and other methods reduction.
Biomaterial scaffold architecture has not been investigated as a tunable source of influence on spinal cord regeneration. This study compared regeneration in transected within various designed-macro-architecture scaffolds to determine if these architectures alone could enhance Three-dimensional (3-D) designs were created and molds built 3-D printer. Salt-leached porous poly(ɛ-caprolactone) was cast five different macro-architectures: cylinder, tube, channel, open-path with core, without...
Summary The characteristics of dissolved organic matter ( DOM ) in soils are often determined through laboratory experiments. Many different protocols can be used to extract from soil. In this study, we five air‐dried compare three extraction methods for water‐extractable WEOM as follows: (i) pressurised hot‐water‐extractable carbon PH‐WEOC ), a percolation at high pressure and temperature; (ii) WEOC 1‐hour end‐over shaking; (iii) leaching‐extractable LEOC leaching soil columns ambient...
OBJECTIVE Systematic multidisciplinary approaches to improving quality and safety in complex surgical care have shown promise. Complication rates from spine surgery range 10% 90% for all surgeries, the overall mortality rate is 1%-4%. These suggest need improved perioperative processes designed minimize risk improve quality. METHODS The Group Health Research Institute Virginia Mason Medical Center implemented a systematic protocol, Seattle Spine Team Protocol, 2010. This protocol involves...
The present study aims to document historical mining and smelting activities by means of geochemical pollen analyses performed in a peat bog core collected around the Bibracte oppidum (Morvan, France), largest settlement great Aeduan Celtic tribe (ca. 180 B.C. 25 A.D.). anthropogenic Pb profile indicates local operations starting from Late Bronze Age, ca. cal. 1300 Lead inputs peaked at height civilization then decreased after Roman conquest Gaul, when site was abandoned. Other phases are...
OBJECTIVE Policies of regionalization and selective referral for a number "high-risk" surgical procedures are being explored implemented as result significant variation in postoperative mortality between high- low-volume providers. The effect provider volume on outcomes after intracranial tumor resection is unknown warrants investigation. METHODS By use the Nationwide Inpatient Sample 1996 1997, patients (older than 19 yr) who had diagnosis malignant central nervous system neoplasm underwent...