A5009875412- Global Cancer Incidence and Screening
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Economic and Financial Impacts of Cancer
- Diatoms and Algae Research
- Esophageal Cancer Research and Treatment
- Molecular Biology Techniques and Applications
- Biomedical Text Mining and Ontologies
- Lung Cancer Treatments and Mutations
- Forensic and Genetic Research
- Colorectal Cancer Screening and Detection
- Biochemical and Molecular Research
- Cancer Genomics and Diagnostics
- Semantic Web and Ontologies
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Data Quality and Management
- Cancer-related gene regulation
- Enzyme Structure and Function
- COVID-19 and healthcare impacts
- Environmental Science and Water Management
- Water Treatment and Disinfection
- Health, Environment, Cognitive Aging
Joint Research Centre
2014-2024
Universidade Federal do Rio de Janeiro
2024
Centro de Investigação em Biodiversidade e Recursos Genéticos
2019
Universidade do Porto
2008-2019
Polícia Judiciária
2017-2018
National Legal Medicine Institute
2009-2011
Hospital de Santa Maria
2011
University of Trás-os-Montes and Alto Douro
2010
ZF Screens (Netherlands)
2010
MRC Holland (Netherlands)
2007-2009
IntroductionEurope is an important focus for compiling accurate and up-to-date world cancer statistics owing to its large share of the world's total burden. This article presents incidence mortality estimates 25 major cancers across 40 individual countries within European areas Union (EU-27) year 2020.MethodsThe estimated national rates are based on statistical methodology previously applied verified using most recently collected data from 151 population-based registries, 2020 population...
Abstract The Water Framework Directive (WFD), 2000/60/EC, requires an integrated approach to the monitoring and assessment of quality surface water bodies. chemical status is based on compliance with legally binding Environmental Quality Standards (EQSs) for selected pollutants (priority substances) EU-wide concern. In context mandate period 2010 2012 subgroup Chemical Monitoring Emerging Pollutants (CMEP) under Common Implementation Strategy (CIS) WFD, a specific task was established...
Juvenile polyposis syndrome (JPS) is a rare autosomal dominant disorder characterised by multiple gastrointestinal juvenile polyps and an increased risk of colorectal cancer. This caused germline mutation either SMAD4 or BMPR1A, possibly ENG. PTEN, originally linked to Cowden Bannayan-Riley-Ruvalcaba syndrome, has also been associated with JPS. By direct sequencing, mutations are found in only 30-40% patients JPS phenotype. Therefore, alternative ways inactivation the known genes, additional...
The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two of 14 or 19 substances concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, plasticizer), each present at its safety limit concentration imposed European legislation, were prepared for their toxic effects. effects assessed 35 bioassays, based on 11...
The aim of the present study was to investigate effect silver nanoparticles (AgNP) different sizes toward two primary producer aquatic species. Thalassiosira pseudonana and Synechococcus sp. have been selected as representative models for lower trophic organisms in marine freshwater habitats, respectively. Time-dependent cellular growth measured upon exposure both AgNP nitrate (AgNO(3)). In addition, behavior waters has followed by CPS disc centrifuge, time frame studies, kinetic release...
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants ubiquitously distributed. They generated by incomplete combustion of organic materials such as wood or fossil fuels. Due to their carcinogenic, mutagenic effects and wide distribution in the environment, these pose many concerns researchers regulators. In our laboratories we investigated effect benzo(a)pyrene (BaP) exposure marine diatom Thalassiosira pseudonana, which has become an important model organism aquatic...
Diatoms are unicellular, photosynthetic, eukaryotic algae with a ubiquitous distribution in water environments and they play an important role the carbon cycle. Molecular or morphological changes these species under ecological stress conditions expected to serve as early indicators of toxicity can point global impact on entire ecosystem. Thalassiosira pseudonana, marine diatom first fully sequenced genome has been selected aquatic model organism for ecotoxicological studies using molecular...
LKB1/STK11 germline inactivations are identified in the majority (66–94%) of Peutz–Jeghers syndrome (PJS) patients. Therefore, defects other genes or so far unidentified ways LKB1 inactivation may cause PJS. The encoding MARK proteins, homologues Par1 polarity protein that associates with Par4/Lkb1, were analyzed this study because their link to and cell polarity. genetic defect underlying PJS was determined through analysis both all four genes. point mutations small deletions 18 23 families...
Population-based Cancer Registries (PBCRs) are tasked with collecting high-quality data, important for monitoring cancer burden and its trends, planning evaluating control activities, clinical epidemiological research development of health policies. The main indicators to measure data quality validity, completeness, comparability timeliness. aim this article is evaluate the PBCRs collected in first ENCR-JRC call, dated 2015.All malignant tumours, except skin non-melanoma, situ uncertain...
The main objective of this research project (“Fate Sees”) was to verify on a European-wide scale the occurrence as many possible organic and inorganic chemical contaminants in WWTP effluents, order get European overview. In year 2010, effluents from 90 waste water treatment plants (WWTPs) were collected analysed total for 160 chemicals 20 trace elements. analyses complemented by applying also effect-based monitoring approaches aiming at estrogenicity dioxin-like toxicity vitro reporter gene...
Abstract Background The coronavirus disease COVID-19 pandemic posed a number of challenges to the oncology community, particularly diagnosis and care cancer patients while ensuring safety from virus for both professionals: minimization visits hospital, cancellation screening programmes difficulties in management operation registries (CRs) working remotely. This article describes effects medium term first wave on registration Europe, focusing changes detection treatment, possible reduction CR...
Background Gastric and oesophageal cancers pose a serious public health concern. In 2020 total of 189,031 incident cases (136,038 stomach, 52,993 oesophagus) 142,508 deaths (96,997 45,511 were estimated in Europe. Oesophago-gastric are heterogeneous disease, with different aetiology epidemiology for the various topographic subsites main histopathological types. Topography subsite morphology is key information to allow differentiating oesophago-gastric cancers. Correct registration coding...
Este estudo analisou os desafios e as perspectivas do uso da tecnologia na prática docente, considerando sua influência no processo de ensino aprendizagem. O problema investigado foi compreender quais obstáculos oportunidades professores enfrentam incorporação ferramentas tecnológicas ao ensino. objetivo geral consistiu em examinar impactos das tecnologias educacionais, destacando estruturais pedagógicos possibilidades inovação Para isso, utilizou-se a metodologia pesquisa bibliográfica,...
CDC4/FBXW7, encoding a ubiquitin ligase, maps to 4q32 and has been implicated as tumor suppressor gene therapeutic target in many types. Mutations colonic adenomas, the frequent losses on 4q described gastric cancer prompt speculation about role of CDC4/FBXW7 carcinogenesis.We assessed cancer, through loss heterozygosity (LOH) multiplex ligation-dependent probe amplification (MLPA) 47 flow-sorted carcinomas including early-onset cancers (EOGC) xenografted conventional carcinomas. Ploidy...
The core activity of population-based cancer registries (PBCRs) is to gather information from all new cases in a defined geographic area, order measure the magnitude burden and provide basis for research. Joint Research Centre-European Network Cancer Registries Quality Check Software (JRC-ENCR QCS) Java standalone desktop application, under development since 2015, created support PBCRs validation collected data. JRC-ENCR QCS performs internal consistency checks on registry dataset, detect...
In the following article an electron/ion microscopy study will be presented which investigates uptake of silver nanoparticles (AgNPs) by marine diatom Thalassiosira pseudonana, a primary producer aquatic species. This organism has characteristic silica exoskeleton that may represent barrier for some chemical pollutants, including (NPs), but presents technical challenge when attempting to use electron-microscopy (EM) methods NP uptake. Here we present convenient method detect NPs interacting...
Population-based cancer registries constitute an important information source in epidemiology. Studies collating and comparing data across regional national boundaries have proved for deploying evaluating effective cancer-control strategies. A critical aspect correctly indicators lies ensuring a good harmonised level of quality, which is primary motivator centralised collection pseudonymised data. The recent introduction the European Union's general data-protection regulation (GDPR) imposes...