A5045321774- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- Pharmaceutical and Antibiotic Environmental Impacts
- Diatoms and Algae Research
- Animal testing and alternatives
- Carcinogens and Genotoxicity Assessment
- Pesticide and Herbicide Environmental Studies
- Pesticide Exposure and Toxicity
- Pesticide Residue Analysis and Safety
- Chemical Safety and Risk Management
- Chemistry and Chemical Engineering
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Anesthesia and Neurotoxicity Research
- Microbial bioremediation and biosurfactants
- Analytical Chemistry and Sensors
- Food Safety and Hygiene
- Sustainable Agricultural Systems Analysis
- Analytical chemistry methods development
- Computational Drug Discovery Methods
- Agricultural safety and regulations
- Plant and animal studies
- Microbial Community Ecology and Physiology
- Groundwater flow and contamination studies
Joint Research Centre
2015-2024
European Commission
2018
Augenklinik Universitätsallee
2015
European Food Safety Authority
2011-2015
Helmholtz Centre for Environmental Research
2004-2007
Stockholm University
2007
University of Basel
2007
Deutsches Biomasseforschungszentrum
2002-2004
A broad spectrum of cytotoxicity assays is currently used in the fields (eco)toxicology and pharmacology. To choose an appropriate assay, different parameters like test compounds, detection mechanism, specificity, sensitivity have to be considered. Furthermore, tissue or cell line can influence performance. For zebrafish (Danio rerio), as emerging model organism, lines are now increasingly used, but few studies examined these systems. Therefore, we compared four liver line, ZFL, differently...
Currently, the identification of chemicals that have potential to induce developmental neurotoxicity (DNT) is based on animal testing. Since at regulatory level, systematic testing DNT not a standard requirement within EU or USA chemical legislation safety assessment, only performed in higher tiered triggered structure activity relationships evidence systemic acute repeated dose toxicity studies. However, these triggers are rarely used and, addition, do always serve as reliable indicators...
Summary: Per- and polyfluoroalkyl substances (PFASs) are man-made chemicals that contain at least one perfluoroalkyl moiety, –CnF2n–. To date, over 4,000 unique PFASs have been used in technical applications consumer products, some of them detected globally human wildlife biomonitoring studies. Because their extraordinary persistence, environmental exposure to will be a long-term source concern. Some such as perfluorooctanoic acid (PFOA) perfluorooctanesulfonic (PFOS) investigated...
Abstract Background In light of the vulnerability developing brain, mixture risk assessment (MRA) for evaluation developmental neurotoxicity (DNT) should be implemented, since infants and children are co-exposed to more than one chemical at a time. One possible approach tackle MRA could cluster DNT chemicals in on basis their mode action (MoA) into ‘similar’ ‘dissimilar’, but still contributing same adverse outcome, anchor assays common key events (CKEs) identified DNT-specific outcome...
Regulating chemical mixtures is a complex scientific and policy task. The aim of this study was to investigate typical their potential risks based on internal exposure levels in the European population. Based human biomonitoring (HBM) data made available via HBM4EU project, we derived generic representative median (P50) worst-case scenario (P95) for adults children. We performed mixture risk assessment HBM concentrations, health-based guidance values (HBGVs) as thresholds concern,...
Diatoms are unicellular, photosynthetic, eukaryotic algae with a ubiquitous distribution in water environments and they play an important role the carbon cycle. Molecular or morphological changes these species under ecological stress conditions expected to serve as early indicators of toxicity can point global impact on entire ecosystem. Thalassiosira pseudonana, marine diatom first fully sequenced genome has been selected aquatic model organism for ecotoxicological studies using molecular...
Abstract The scientific consensus model USEtox ® is recommended by the European Commission as reference to characterize life cycle chemical emissions in terms of their potential human toxicity and freshwater aquatic ecotoxicity impacts context International Reference Life Cycle Data System Handbook Environmental Footprint pilot phase looking at products (PEF) organizations (OEF). Consequently, this has been systematically used within PEF/OEF 25 Union industry sectors, which manufacture a...
In the present review, we compiled and evaluated available information supporting assessment of population community recovery after pesticide application. This is crucial for environmental risk pesticides. We reviewed more than 3900 manuscripts on those organism groups relevant or likely to become procedures in Europe, that is, aquatic invertebrates, algae, plants, fish, microbes, amphibians, as well birds mammals, non-target terrestrial arthropods including honeybees, non-arthropod...
Human biomonitoring (HBM) data can provide insight into co-exposure patterns resulting from exposure to multiple chemicals various sources and over time. Therefore, such are particularly valuable for assessing potential risks combined chemicals. One way interpret HBM is establishing safe levels in blood or urine, called Biomonitoring Equivalents (BE) health based guidance values (HBM-HBGV). These be derived by converting established external reference values, as tolerable daily intake (TDI)...
Prenatal and postnatal co-exposure to multiple chemicals at the same time may have deleterious effects on developing nervous system. We previously showed that acting through similar mode of action (MoA) grouped based perturbation brain derived neurotrophic factor (BDNF), induced greater neurotoxic human pluripotent stem cell (hiPSC)-derived neurons astrocytes compared with dissimilar MoA. Here we assessed repeated dose (14 days) treatments mixtures containing six tested in our previous study...
There is growing evidence that single substances present below their individual thresholds of effect may still contribute to combined effects. In component-based mixture risk assessment (MRA), the risks can be addressed using information on components. This is, however, often hampered by limited availability ecotoxicity data. Here, possible use ecotoxicological threshold concentrations no concern (i.e. 5th percentile statistical distribution values) investigated fill data gaps in MRA.For...
Pesticides can be an important stressor to aquatic ecosystems, and their use is strictly regulated in the European Union (EU). However, data on of pesticides are rather limited poorly available, monitoring often insufficient characterize actual exposure impact. The aim work presented here harness available assess, for first time, distribution concentrations toxicity 148 pesticide active substances (AS) whole EU. Starting from estimates agriculture a simple screening-level model fate...
The global increase in pesticide use has raised concerns about its impact on biodiversity, ecosystems, and human health, particular of people living near agricultural areas. This study explores the assessment exposure risks to residents at a high spatial granularity using plant protection product data. Our objective was develop an indicator monitor risk levels faced by France integrating datasets methodologies. Using spatialized sales data based crop authorizations, we mapped potential loads...
ABSTRACT Standard risk assessment of plant protection products (PPP) combines “worst‐case” exposure scenarios with effect thresholds using (safety) factors to account for uncertainties. If needed, risks can be addressed applying more realistic conditions at higher tiers, which refine and/or assessments additional data. However, it is not possible investigate the wide range potential experimentally. In contrast, ecotoxicological mechanistic models do allow addressing a multitude scenarios....