A5079950148- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Pain Management and Placebo Effect
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Psychosomatic Disorders and Their Treatments
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Biochemical effects in animals
- Music Therapy and Health
- Heart Rate Variability and Autonomic Control
- Regulation of Appetite and Obesity
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Eosinophilic Esophagitis
- Pediatric Pain Management Techniques
- Cardiovascular Syncope and Autonomic Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Functional Brain Connectivity Studies
- Workaholism, burnout, and well-being
- Acupuncture Treatment Research Studies
- Bariatric Surgery and Outcomes
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
Rijksinstituut voor Ziekte- en Invaliditeitsverzekering
2024
KU Leuven
2011-2023
Bridge University
2017
Background The stomach relaxes upon food intake and thereby provides a reservoir while keeping the intragastric pressure (IGP) low. We set out to determine whether we could use IGP as measurement for accommodation during intake. Methods In fasted healthy volunteers (n = 7–17) manometer an infusion catheter were positioned in proximal stomach. After stabilization period nutrient drink was intragastrically infused at 15, 30 60 mL min−1. To investigate effect of impaired...
Abstract Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, autonomic responses to corticotropin-releasing hormone (CRH) administration as well brain activity alterations in IBS. The study included 28 IBS patients 34 age sex-matched healthy control subjects. demonstrated greater...
Interoceptive fear learning and generalization have been hypothesized to play a key role in unexplained abdominal esophageal pain patients with functional gastrointestinal disorders. However, there is no experimental evidence demonstrating that visceral sensations can be established humans alter perception.In novel learning-generalization paradigm, an innocuous balloon distension served as conditioned stimulus (CS), distensions at three different pressure levels around the detection...
Background: Functional dyspepsia (FD) is a prevalent functional gastrointestinal disorder (FGID) defined by chronic epigastric symptoms in the absence of organic abnormalities likely to explain them. Comorbidity with mood and anxiety disorders as well other FGIDs somatic syndrome (FSS) high. FD characterized abnormal regional cerebral activity cognitive/affective pain modulatory circuits, but it unknown which neurotransmitter systems are involved. The authors aimed assess compare vivo...
Abstract Background Patients with Crohn's disease ( CD ) in remission are exposed to chronic psychological distress, due the constant risk of relapse. This permanent situation anticipation and uncertainty can lead anxiety, which may, turn, trigger We aimed investigate effects on behavioral brain responses visceral discomfort quiescent patients. Methods Barostat‐controlled rectal distensions were preceded by cued uncertain or certain nine patients matched healthy volunteers. Brain obtained...
This study investigates the prevalence of different types childhood adversities (CA) and posttraumatic stress disorder (PTSD) in female patients with Fibromyalgia or Chronic Widespread Pain (FM/CWP) compared to Functional Dyspepsia (FD) achalasia. In FM/CWP, we also investigated association between CA PTSD on one hand pain severity other.Patient samples consisted 154 83 FD 53 achalasia consecutively recruited from a tertiary care hospital. Well-validated self-report questionnaires were used...
Abstract Although of great public health relevance, the mechanisms underlying disordered eating behavior and body weight regulation remain insufficiently understood. Compelling preclinical evidence corroborates a critical role endocannabinoid system (ECS) in central appetite food intake. However, vivo human on ECS functioning brain circuits involved intake as well its relationship with is lacking, both disease. Here, we measured cannabinoid 1 receptor (CB R) availability using positron...
Irritable bowel syndrome (IBS) often comorbids mood and anxiety disorders. Corticotropin-releasing hormone (CRH) is a major mediator of the stress response in brain-gut axis, but it not clear how CRH agonists change human brain responses to interoceptive stimuli. We tested hypothesis that activation colorectal distention enhanced after injection IBS patients compared healthy controls. Brain H215O- positron emission tomography (PET) was performed 16 male age-matched controls during baseline,...
Introduction Spinal cord stimulation is a common treatment option for neuropathic pain conditions. Despite its extensive use and multiple technological evolutions, long term efficacy of spinal debated. Most studies on include rather limited number patients and/or follow-ups over period. Therefore, there an urgent need real-world, long-term data. Methods In 2018, the Belgian government initiated nationwide secure platform follow-up all new existing therapies. This unique approach used...
We investigated whether certainty and uncertainty of impending aversive visceral sensation differently modulate regional brain activity, both during anticipation in irritable bowel syndrome (IBS) patients compared with healthy controls.Twenty-six IBS (14 women) 29 controls (15 were enrolled a functional magnetic resonance imaging study. Participants received rectal distention at an individually titrated severe discomfort level that was preceded by visual cues to induce certain (100% chance...
Irritable bowel syndrome (IBS) is a functional disorder of brain-gut interactions. Differential brain responses to rectal distention between IBS and healthy controls (HCs) have been demonstrated, particularly in the pain matrix default mode network. This study aims compare resting-state properties these networks patients HCs using graph analysis two independent cohorts. We used weighted adjacency based on partial correlations time series different regions each subject determine specific...
In DSM-5, pain-related fear during anticipation of vaginal penetration is a diagnostic criterion Genito-Pelvic Pain/Penetration Disorder (GPPPD). We aimed to investigate subjective and brain responses anticipatory subsequent induction vestibular pain in women with GPPPD.Women GPPPD (n = 18) age-matched healthy controls (HC) 15) underwent fMRI scanning at individually titrated threshold after cued period. (Pain-related) anxiety traits were measured questionnaires prior scanning, intensity...
Peripheral infusion of glucagon-like peptide-1 (GLP-1) can affect brain activity in areas involved the regulation appetite, including hypothalamic and reward-related regions. In contrast, physiological role endogenous GLP-1 central appetite has hardly been investigated.This was a randomized, cross-over trial that 12 healthy volunteers who received an intragastric (ig) glucose (gluc) load, with or without intravenous (iv) exendin9-39 (ex9-39; specific receptor antagonist). Functional magnetic...
Abstract Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such affect-induced symptoms in patients. Thirty patients with fibromyalgia and/or IBS 30 healthy controls (all women) watched neutral, positive picture blocks during functional MRI scanning rated affect after every block. We...
Opioidergic neurotransmission in the central nervous system is involved somatic pain, but its role visceral pain remains unknown. We aimed to quantify endogenous opioid release brain during sustained painful gastric distension. Therefore, 2 dynamic [11C]carfentanil positron emission tomography scans were performed 20 healthy subjects conditions: (20 minutes) proximal balloon distension at predetermined individual discomfort threshold (PAIN) and no (NO PAIN), counterbalanced order. Pain...