A5041077301- Aortic aneurysm repair treatments
- Microfluidic and Bio-sensing Technologies
- Infectious Aortic and Vascular Conditions
- Collagen: Extraction and Characterization
- 3D Printing in Biomedical Research
- Aortic Disease and Treatment Approaches
- Innovative Microfluidic and Catalytic Techniques Innovation
- Skin Protection and Aging
- Bone health and treatments
- Diabetes and associated disorders
- Microfluidic and Capillary Electrophoresis Applications
- Central Venous Catheters and Hemodialysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bone Tissue Engineering Materials
- Dermatological and Skeletal Disorders
- Peripheral Artery Disease Management
- Genomics and Phylogenetic Studies
- Dental Implant Techniques and Outcomes
- Parathyroid Disorders and Treatments
- Occupational and environmental lung diseases
- Kidney Stones and Urolithiasis Treatments
- Blood groups and transfusion
- Protease and Inhibitor Mechanisms
- Bacterial Genetics and Biotechnology
- Erythrocyte Function and Pathophysiology
Bowdoin College
2023-2025
Medical University of South Carolina
2020-2023
Clemson University
2015-2019
Edwards Lifesciences (United States)
2015
University of California, Irvine
2015
Prisma Health
2015
Rationale: Matrix metalloproteinases (MMPs)–mediated extracellular matrix destruction is the major cause of development and progression abdominal aortic aneurysms. Systemic treatments MMP inhibitors have shown effectiveness in animal models, but it did not translate to clinical success either because low doses used or systemic side effects inhibitors. We propose a targeted nanoparticle (NP)–based delivery inhibitor at aneurysms site. Such therapy will be an attractive option for preventing...
Degeneration of elastic lamina and vascular calcification are common features pathology such as aortic aneurysms.We tested whether dual therapy with targeted nanoparticles (NPs) can remove mineral deposits (by delivery a chelating agent, ethylene diamine tetraacetic acid (EDTA)) restore polyphenol, pentagalloyl glucose (PGG)) to reverse moderate aneurysm development.EDTA followed by PGG NP led reduction in macrophage recruitment, matrix metalloproteinase (MMP) activity, elastin degradation...
Medial arterial calcification (MAC) is a common outcome in diabetes and chronic kidney disease (CKD). It occurs as linear mineral deposits along the degraded elastin lamellae responsible for increased aortic stiffness subsequent cardiovascular events. Current treatments calcification, particularly CKD, are predominantly focused on regulating disturbance other risk factors. Ethylene diamine tetraacetic acid (EDTA), chelating agent, can resorb deposits, but systemic delivery of EDTA may cause...
Glycans that coat the surface of bacteria are compelling antibiotic targets because they contain distinct monosaccharides linked to pathogenesis and absent in human cells. Disrupting glycan biosynthesis presents a path inhibiting ability bacterium infect host. We previously demonstrated O-glycosides act as metabolic inhibitors disrupt bacterial biosynthesis. Inspired by recent study which showed thioglycosides (S-glycosides) 10 times more effective than at mammalian cells, we crafted panel...
Cell migration is a vital part of immune responses, growth, and wound healing. complex process that involves interactions between cells, the extracellular matrix, soluble non-soluble chemical factors (e.g., chemoattractants). Standard methods for measuring such as Boyden chamber assay, work by counting cells on either side divider. These techniques are easy to use; however, they offer little geometric modification different applications. In contrast, microfluidic devices can be used observe...
Cell migration is a vital part of immune responses, growth, and wound healing. complex process that involves interactions between cells, the extracellular matrix, soluble non-soluble chemical factors (e.g., chemoattractants). Standard methods for measuring such as Boyden chamber assay, work by counting cells on either side divider. These techniques are easy to use; however, they offer little geometric modification different applications. In contrast, microfluidic devices can be used observe...
Abstract Introduction The two most common autoimmune disorders affecting the thyroid gland, namely Graves’ disease and Hashimoto's thyroiditis, represent opposite ends of same spectrum. They can rarely co-exist in patient (1) leading to an unpredictable clinical course pose a therapeutic challenge, necessitating close monitoring. We present unique case female who switched multiple times between hypothyroid hyperthyroid state due co-existence both thyroiditis disease. Case Description A...