A5100734962- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Synthesis and Reactivity of Heterocycles
- Neurological Disease Mechanisms and Treatments
- Reproductive Biology and Fertility
- Phytochemicals and Antioxidant Activities
- Sperm and Testicular Function
- Neurotransmitter Receptor Influence on Behavior
- Synthesis and Characterization of Pyrroles
- Luminescence and Fluorescent Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Phytochemistry and Biological Activities
- Organic Electronics and Photovoltaics
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Heat shock proteins research
- Ovarian function and disorders
- Diverse Approaches in Healthcare and Education Studies
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Organic Light-Emitting Diodes Research
- Skin Protection and Aging
Yonsei University
2014-2025
Seoul Women's University
2010-2025
Asan Medical Center
2025
YD Global Life Science (South Korea)
2024
Korea University
2013-2024
Kyungpook National University
2013-2023
Korea Institute of Science and Technology
2022
Severance Hospital
2010-2021
Seoul National University
2017
Kangwon National University
2008-2017
Alzheimer disease (AD) is a progressive neurodegenerative disease, which characterized by loss of memory and cognitive function. In AD patients dysfunction the cholinergic system main cause disorders, decreased activity choline acetyltransferase (ChAT), an enzyme responsible for acetylcholine (ACh) synthesis, observed. present study we investigated if brain transplantation human neural stem cells (NSCs) genetically modified to encode ChAT gene improves function kainic acid (KA)-induced...
Abstract Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral cognitive dysfunction from decreased acetylcholine biosynthesis reduced secretion growth neurotrophic factors. Human adipose tissue‐derived mesenchymal stem cells (ADMSCs) were intravenously (1 × 10 6 cells) or intracerebroventricularly (4 5 transplanted into brains 18‐month‐old mice once four times at 2‐week intervals. Transplantation ADMSCs improved both...
The regulation of hypoxia-inducible factor-1α (HIF-1α) during endochondral bone formation is not fully understood. Here, we investigated the cross-talk between HIF-1α and Runt-related transcription factor 2 (Runx2) in growth plate. Runx2 caused accumulation protein ATDC5 chondrocytes HEK293 cells under normoxic conditions. also increased nuclear translocation when coexpressed interacted with at oxygen-dependent degradation domain (ODDD). In addition, competed von Hippel-Lindau tumor...
Chronic exposure to ultraviolet B (UVB) is a major cause of skin aging. The aim the present study was determine photoprotective effect 30% ethanol extract
The protective effect of panduratin A, isolated from Kaempferia pandurata ROXB. (Zingiberaceae), against tert-butylhydroperoxide (t-BHP)-induced cytotoxicity was investigated in a human hepatoma cell line, HepG2. tetrazolium dye colorimetric test (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay) used to monitor cytotoxicity. Lipid peroxidation [malondialdehyde (MDA) formation] and intracellular glutathione level were estimated by fluorometric methods. Intracellular...
This study investigated the hypothesis that a sorghum extract exerts anti-diabetic effects through mechanism improves insulin sensitivity via peroxisome proliferator-activated receptor gamma (PPAR-γ) from adipose tissue. Seven C57BL/6 mice were fed an AIN-93M diet with fat consisting of 10% total energy intake (LF) for 14 weeks, and 21 high-fat AIN 60% calories derived (HF). From week 8, HF diet-fed orally administered either saline (HF group), 0.5% (0.5% SE or 1% (1% group) 6 weeks (n =...
Hydrangea serrata (THUNB.) SER. (Hydrangeaceae) leaves have been used as herbal teas in Korea and Japan. The objective of this study was to identify anti-photoaging compounds aqueous EtOH extract prepared from H. their effects on UVB-irradiated Hs68 human foreskin fibroblasts. Phytochemical led the isolation characterization ten compounds: hydrangenol, thunberginol A, C, hydrangenoside cudrabibenzyl 2,3,4'-trihydroxystilbene, F, quercetin 3-O-β-D-xylopyranosyl (1-2)-β-D-galactopyranoside,...
We used exome sequencing of blood DNA in four unrelated patients to identify the genetic basis metaphyseal chondromatosis with urinary excretion D-2-hydroxy-glutaric acid (MC-HGA), a rare entity comprising severe chondrodysplasia, organic aciduria, and variable cerebral involvement. No evidence for recessive mutations was found; instead, two showed IDH1 predicting p.R132H p.R132S as apparent somatic mosaicism. Sanger confirmed presence mutation one patient, saliva (but not fibroblast) other...
Investigating the exact pathophysiology of obstructive sleep apnea syndrome (OSAS)-induced hearing loss is critical. We sought to verify hypothesis that a correlation exists between mitochondrial dysfunction in inner ear hair cells and auditory induced by chronic intermittent hypoxia (CIH) murine model apnea. C57BL/6J adult male mice were randomized 4 weeks CIH (n = 12) or normoxia (Sham) 12). Hearing threshold was determined brainstem response. The activity mitochondria compared Sham mice....
Abstract Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated blue-enriched white LT on sleep, cognition, mood and behavior mild moderate AD. The group (n = 14) sat about 60 cm away from a small (136 × 73 16 mm) LED box for 1 h each morning 2 weeks. control 11) wore dark, blue-attenuating sunglasses during exposures. started 9–10 after individual’s dim melatonin onset (DLMO). Assessments were...
Objectives: Augmented reality (AR) navigation systems are emerging to simplify and enhance the precision of medical procedures. Lumbosacral transforaminal epidural injection is a commonly performed procedure for treatment diagnosis radiculopathy. Accurate needle placement while avoiding critical structures remains challenge. For this purpose, we conducted randomized controlled trial our augmented system. Methods: This study involved 28 patients, split between traditional C-arm guided group...
Kaempferide, kaempferol, and galangin belong to flavonol, one of flavonoid classes. Even they have the same moiety as their binding affinities for a hexahistidine-tagged C-terminal nucleotide-binding domain are different with each other. The dissociation constants kaempferide, 10.1, 4.5, 6.7, 5.3 mM, respectively. Galangin contains two more hydroxyl groups than kaempferol has three groups. Kaempferide differs in only substituent: 4'-hydroxyl group is switched 4'-methoxyl kaempferide....
Aberrant structures of site-specific N-linked glycans are closely associated with the tumorigenesis hepatocellular carcinoma (HCC), one most common fatal cancers worldwide. Vitronectin (VTN) is considered a candidate glycobiomarker HCC. In this study, we describe reliable and simple quantification strategy based on abundance ratios glycopeptides VTN to screen for potential biomarkers. A total 14 unique corresponding 27 were characterized at three sites (Asn-86, -169, -242) present in VTN....
As a starting point of the Chromosome-Centric Human Proteome Project (C-HPP), we established strategies genome-wide proteomic analysis, including protein identification, quantitation disease-specific proteins, and assessment post-translational modifications, using paired human placental tissues from healthy preeclampsia patients. This analysis resulted in identification 4239 unique proteins with high confidence (two or more peptides false discovery rate less than 1%), covering 21%...
Increasing the number of phenylcarbazole (PC) units attached to silicon atom in organic solid-state thin films led a remarkable enhancement charge mobility. Specifically, mobility values exhibited an increase from 1.32 × 10−4 cm2/Vs for 3PCBP 4.39 10–4 2MCBP, ultimately reaching 1.16 10–3 MCBP. Notably, these enhancements were achieved while maintaining high triplet energy 3.01 eV. DFT calculations on spin density distribution provided insights into nature improved preserving energy. The...
Specific differences between interviewer-rated and self-report suicide risk assessments are unknown. This descriptive cross-sectional study examined the acceptance of Columbia-Suicide Severity Rating Scale (C-SSRS) screener, conducted by nurse-interviewers versus self-reporting, identified factors contributing to refusal in each mode. We reviewed charts inpatients at a general hospital that included C-SSRS screener time admission. screening nurse-interviewer self-reported mode were included....