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Pascal C. Rauher

ORCID: 0000-0002-6121-8893
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About
Contact & Profiles
A5068761025
Research Areas
  • Mitochondrial Function and Pathology
  • Cancer, Lipids, and Metabolism
  • Cancer, Hypoxia, and Metabolism
  • Lipid metabolism and biosynthesis
  • Adipose Tissue and Metabolism
  • Cancer-related molecular mechanisms research

University of Zurich
 2019-2021

 MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes
OPENALEX - Publications 
Christophe Alexis Cédric Freyre Pascal C. Rauher Christer S. Ejsing Robin W. Klemm

10.1016/j.molcel.2019.09.011 article EN publisher-specific-oa Molecular Cell 2019-10-15
 Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells
OPENALEX - Publications 
Mara Artibani Kenta Masuda Zhiyuan Hu Pascal C. Rauher Garry Mallett and 26 more Nina Wietek Matteo Morotti Kay Y. Chong Mohammad KaramiNejadRanjbar Christos E. Zois Sunanda Dhar Salma El-Sahhar Leticia Campo Sarah P. Blagden Stephen Damato Pubudu Pathiraja Shibani Nicum Fergus Gleeson Alexandros Laios Abdulkhaliq Alsaadi Laura Santana González Takeshi Motohara Ashwag Albukhari Zhen Lü Robert C. Bast Adrian L. Harris Christer S. Ejsing Robin W. Klemm Christopher Yau Tatjana Sauka‐Spengler Ahmed A. Ahmed

Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular characteristics solid tumor MRD drivers their survival have remained elusive. Here we performed dense multiregion transcriptomics analysis paired biopsies from 17 ovarian cancer patients before after chemotherapy. We reveal that while share important signatures with TICs, they are also characterized by an adipocyte-like gene expression...

10.1172/jci.insight.147929 article EN cc-by JCI Insight 2021-05-04
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