A5039640218- Spectroscopy and Chemometric Analyses
- Fault Detection and Control Systems
- Spectroscopy Techniques in Biomedical and Chemical Research
- Viral Infectious Diseases and Gene Expression in Insects
- Mineral Processing and Grinding
- Water Quality Monitoring and Analysis
- Biodiesel Production and Applications
- Advanced Chemical Sensor Technologies
- Advanced Statistical Process Monitoring
- Microbial Metabolic Engineering and Bioproduction
- Meat and Animal Product Quality
- Crystallization and Solubility Studies
- Protein purification and stability
- Analytical Methods in Pharmaceuticals
- Pesticide Residue Analysis and Safety
- Biofuel production and bioconversion
- Listeria monocytogenes in Food Safety
- Control Systems and Identification
- Advanced Control Systems Optimization
- Pharmaceutical Quality and Counterfeiting
- Manufacturing Process and Optimization
- Analytical Chemistry and Chromatography
- Biosimilars and Bioanalytical Methods
- Tuberculosis Research and Epidemiology
- Genetic and phenotypic traits in livestock
Hindustan Institute of Technology and Science
2024
Institute for Biotechnology and Bioengineering
2009-2021
University of Lisbon
2010-2021
Research Center Pharmaceutical Engineering (Austria)
2013-2014
Instituto Politécnico de Lisboa
1994-2012
Instituto Superior Técnico
1990-2011
Université de Lorraine
2004
Centre National de la Recherche Scientifique
2004
Instituto de Aeronáutica e Espaço
1996
Raman spectroscopy is a suitable monitoring technique for CHO cultivations. However, thorough discussion of peaks, bands, and region assignments to key metabolites culture attributes, the interpretability produced calibrations scarce. That understanding vital long-term predictive ability models, facilitate lifecycle management that comply with regulatory guidelines. Several fed-batch lab-scale mAb mammalian cultivations were carried out, in situ used process state estimation attribute...
Fourier transform infrared (FT-IR) spectroscopy and chemometric techniques were used to discriminate five closely related Salmonella enterica serotype Enteritidis phage types, type 1 (PT1), PT1b, PT4b, PT6, PT6a. Intact cells outer membrane protein (OMP) extracts from bacterial cell membranes subjected FT-IR analysis in transmittance mode. Spectra collected over a wavenumber range 4,000 600 cm(-1). Partial least-squares discriminant (PLS-DA) was develop calibration models based on...
Biodiesel is produced mainly by a transesterification reaction which involves the of vegetable oils, animal fats or waste oils with an alcohol (such as methanol) in presence catalyst sodium hydroxide methoxide). Since contaminants can cause severe engine problems, assessment biodiesel quality very important. This work reports use near infrared (NIR) spectroscopy to determine content water and methanol industrial laboratory-scale samples. A qualitative analysis spectra principal components...
The yield of monoclonal antibody (Mab) production processes depends on media formulation, inocula quality, and process conditions. As in industrial tight cultivation conditions are used, quality viable cell densities controlled to reasonable levels, formulation raw materials lot-to-lot variability will have, those circumstances, the highest impact performance. In particular Mab studied, two different were used: a complex carbon nitrogen source made specific peptones defined chemical...
Introdução: A infertilidade é uma doença definida como a incapacidade de obter gravidez bem-sucedida após 12 meses ou mais relações sexuais regulares e desprotegidas. Diante desse panorama, em novos estudos, durante administração do Plasma Rico Plaquetas (PRP), constatou-se um aumento considerável na espessura média endométrio no 14º dia, resultando taxa clínica 15,6%. Objetivo: Investigar se infusão intrauterina PRP tem efeito positivo nos resultados da para pacientes com falhas implantação...
The performance of an industrial pharmaceutical process (production active ingredient by fermentation, API) was modeled multiblock partial least squares (MBPLS). most important stages are inoculum production and API fermentation. Thirty batches (runs) were produced according to experimental planning. Rather than merging all these data into a single block independent variables (as in ordinary PLS), four blocks used separately (manipulated quality for each stage). With the approach it possible...
Abstract Bootstrap‐based methods have been applied for spectral variable selection in near (NIR) and mid‐infrared (MIR) spectroscopy applications. In this paper, an extension of those the intervals instead single variables is proposed. This approach, interval partial least square (PLS)‐Bootstrap ( i PLS‐Bootstrap), was compared against PLS‐Bootstrap method use whole region model development. These were tested on a NIR dataset obtained from at‐line monitoring industrial fermentation process,...