A5033881528- Terahertz technology and applications
- Drug Solubulity and Delivery Systems
- Optical Coherence Tomography Applications
- Spectroscopy and Chemometric Analyses
- Photoacoustic and Ultrasonic Imaging
- Acoustic Wave Resonator Technologies
- Spectroscopy and Laser Applications
- Crystallization and Solubility Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Chromatography
- Protein purification and stability
- Injection Molding Process and Properties
- Photonic and Optical Devices
- Material Properties and Processing
- Granular flow and fluidized beds
- 3D Printing in Biomedical Research
- Photonic Crystals and Applications
- Advanced Chemical Sensor Technologies
- Additive Manufacturing and 3D Printing Technologies
- Food Drying and Modeling
- Material Dynamics and Properties
- Fault Detection and Control Systems
- Microfluidic and Capillary Electrophoresis Applications
- Coronary Interventions and Diagnostics
- Microencapsulation and Drying Processes
University of Strathclyde
2016-2025
Engineering and Physical Sciences Research Council
2018-2022
University of Cambridge
2016-2018
Research Center Pharmaceutical Engineering (Austria)
2011-2018
Bridge University
2016
Graz University of Technology
2013
A 3D printer was used to realise compartmental dosage forms containing multiple active pharmaceutical ingredient (API) formulations. This work demonstrates the microstructural characterisation of printed solid using X-ray computed microtomography (XμCT) and terahertz pulsed imaging (TPI). Printing performed with either polyvinyl alcohol (PVA) or polylactic acid (PLA). The structures were examined by XμCT TPI. Liquid self-nanoemulsifying drug delivery system (SNEDDS) formulations saquinavir...
<h2>Abstract</h2> We present in-line coating thickness measurements acquired simultaneously using 2 independent sensing modalities: terahertz pulsed imaging (TPI) and optical coherence tomography (OCT). Both techniques are sufficiently fast to resolve the of individual pharmaceutical tablets <i>in situ</i> during film operation, both direct structural that do not require multivariate calibration. The TPI sensor is suitable measure coatings greater than 50 μm can penetrate through thick even...
Novel excipients are entering the market to enhance bioavailability of drug particles by having a high porosity and, thus, providing rapid liquid uptake and disintegration accelerate subsequent dissolution. One example such novel excipient is functionalized calcium carbonate, which enables manufacture compacts with bimodal pore size distribution consisting larger interparticle fine intraparticle pores. Five sets carbonate tablets target 45%-65% were prepared in 5% steps characterized using...
Abstract Porosity, one of the important quality attributes pharmaceutical tablets, directly affects mechanical properties, mass transport and hence tablet disintegration, dissolution ultimately bioavailability an orally administered drug. The ability to accurately quickly monitor porosity tablets during manufacture or manufacturing process will enable a greater assurance product quality. This tutorial systematically outlines steps involved in terahertz-based measurement method that can be...
In this study, a compartmental disintegration and dissolution model is proposed for the prediction evaluation of performance directly compressed tablets. This uses three compartments (Bound, Disintegrated, Dissolved) to describe state each particle active pharmaceutical ingredient. The tablet captured by fitting parameters. Two parameters, β0 βt,0, initial rate change in rate, respectively. A third parameter, α, describes effect volume dissolved drug on process. As disintegrates, particles...
The aim of this study was to establish the suitability terahertz (THz) transmission measurements accurately measure and predict critical quality attributes disintegration time amount active pharmaceutical ingredient (API) dissolved after 15, 20 25 min for commercial tablets processed at production scale. Samples 18 batches biconvex from a production-scale design experiments into exploring space tablet manufacturing process were used. involved steps high-shear wet granulation, fluid-bed...
We show clear evidence for a theory proposing that the shape and structure of PES is fundamental factor underlying dynamics at temperatures below glass transition.
Oral dosage forms are an integral part of modern health care and account for the majority drug delivery systems. Traditionally analysis dissolution behaviour a form is used as key parameter to assess performance product. However, understanding mechanisms disintegration critical importance improve quality The primarily impacted by hydration subsequent swelling powder compact. Here we compare liquid ingress data obtained using terahertz pulsed imaging (TPI) set mathematical models. interlink...
Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets commercial samples studied. Multiple on individual quantify the random errors results. These show that refractive index precise, with standard deviation a single being about 0.002, variation between due small thickness measurement from resolution...
Cost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular widespread form to administer a drug patient. Tablets typically consist an active ingredient selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed facilitate rapid liquid uptake leading disintegration times FCC based in matter seconds. Five sets with target porosity 45–65% 5% steps were prepared characterised using terahertz...