A5089274452- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Protein purification and stability
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microencapsulation and Drying Processes
- Thermography and Photoacoustic Techniques
- Acoustic Wave Resonator Technologies
- Terahertz technology and applications
- Sport and Mega-Event Impacts
- 3D Printing in Biomedical Research
- Canadian Identity and History
- Polysaccharides Composition and Applications
- Cultural Industries and Urban Development
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Granular flow and fluidized beds
- Injection Molding Process and Properties
University of Strathclyde
2020-2024
In this study, a compartmental disintegration and dissolution model is proposed for the prediction evaluation of performance directly compressed tablets. This uses three compartments (Bound, Disintegrated, Dissolved) to describe state each particle active pharmaceutical ingredient. The tablet captured by fitting parameters. Two parameters, β0 βt,0, initial rate change in rate, respectively. A third parameter, α, describes effect volume dissolved drug on process. As disintegrates, particles...
During drug product development, stability studies are used to ensure that the safety and efficacy of a not affected during storage. Any change in dissolution performance must be investigated, as this may indicate bioavailability. In study, three different griseofulvin formulations were prepared containing microcrystalline cellulose (MCC) with either mannitol, lactose monohydrate, or dibasic calcium phosphate anhydrous (DCPA). The tensile strength, porosity, contact angle, disintegration...
With advancements in the pharmaceutical industry pushing more towards tailored medicines, novel approaches to tablet manufacture are high demand. One of main drivers micro-scale batch production is ability fine-tune drug release. This study demonstrates use rapid tooling injection moulding (RTIM) for manufacture. Tablets were manufactured with varying structural features alter surface area whilst maintaining same volume, resulting differing specific (SSA). The precision this technique...
The ceramic materials' properties and the penetrating liquid both influence transport into catalytic materials. Terahertz pulsed imaging (TPI) in combination with a flow cell was used to investigate process of polar less solvents range α-alumina powder compacts. TPI results show that alumina samples largest heating rate (200 °C h−1) have fastest water transport. also reveal 1-octanol takes much longer through than water, as viscosity is larger water. Since semi-transparent terahertz...