A5071956852- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Urticaria and Related Conditions
- Inhalation and Respiratory Drug Delivery
- Drug-Induced Adverse Reactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood properties and coagulation
- Pediatric health and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Inflammatory mediators and NSAID effects
- Nutrition and Health Studies
- Eosinophilic Disorders and Syndromes
- Eosinophilic Esophagitis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Dermatology and Skin Diseases
- Pharmaceutical studies and practices
- Contact Dermatitis and Allergies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nasal Surgery and Airway Studies
- Occupational exposure and asthma
- Pregnancy and Medication Impact
Medical University of Lodz
2015-2025
Regeneron (United States)
2022
AstraZeneca (Brazil)
2022
Triangle
2022
Bristol-Myers Squibb (Switzerland)
2022
Uniwersytecki Szpital Kliniczny w Opolu
2007-2020
Hospital Universitario Infanta Leonor
2015
Philipps University of Marburg
2015
Hospital Doctor José Molina Orosa
2015
Hallym University
2015
Background —Fibrinogen has been identified as an independent risk factor for cardiovascular disease and associated with traditional factors. Also, the role of elevated fibrinogen in thrombosis suggests that it may be on causal pathway certain factors to exert their effect. These associations remain incompletely characterized. Moreover, optimal assay stratification is uncertain. Methods Results —In 2632 subjects from cycle 5 Framingham Offspring Population, levels were determined a newly...
Although extensive evidence indicates that estrogen is responsible for the markedly decreased cardiovascular risk of premenopausal women, mechanism through which might exert its protective effect has not been adequately explained. Since thrombosis now recognized to play an important role in onset disease, we investigated relation between status and fibrinolytic potential, a determinant thrombotic risk.We determined levels plasminogen activator inhibitor (PAI-1) antigen tissue (TPA) 1431...
Systemic inflammation is associated with ischemia and Alzheimer disease (AD). We hypothesized that inflammatory biomarkers would be neuroimaging markers of (i.e., white matter hyperintensities [WMH]) AD total brain volume [TCB]).
Endothelial dysfunction may precede development of type 2 diabetes. We tested the hypothesis that elevated levels hemostatic markers endothelial dysfunction, plasminogen activator inhibitor-1 (PAI-1) antigen, and von Willebrand factor (vWF) antigen predicted incident diabetes independent other risk factors. followed 2,924 Framingham Offspring subjects (54% women, mean age 54 years) without at baseline (defined by treatment, fasting plasma glucose ≥7 or 2-h postchallenge ≥11.1 mmol/l) over 7...
Cardiovascular disease (CVD) risk associated with fat redistribution seen among HIV-infected individuals remains unknown, but may be increased due to hyperlipidemia, hyperinsulinemia, visceral adiposity, and a prothrombotic state these metabolic abnormalities. In this study we characterized plasminogen activator inhibitor-1 (PAI-1) tissue-type (tPA) antigen levels, markers of fibrinolysis CVD risk, in HIV lipodystrophic patients compared controls. Furthermore, investigated the effect...
BackgroundA double-blind, placebo-controlled, phase III study (200622) showed that mepolizumab reduces disease flares for patients with uncontrolled FIP1-like-1-platelet-derived growth factor receptor α–negative hypereosinophilic syndrome (HES) and two or more in the previous year.ObjectiveTo further characterize safety, clinical benefit, pharmacodynamics of mepolizumab.MethodsEligible from both treatment arms double-blind could enter an open-label extension (205203; NCT03306043) to receive...
Many clinical and observational studies have demonstrated effectiveness of omalizumab (OMA) in the treatment severe asthma, but optimal duration therapy remains unknown.The article presents authors' experience on OMA cessation routine practice.Due to new reimbursement criteria, has been interrupted 11 subjects (6 women/5 men). The mean age patients was 50.73 ±14.16 years, time asthma 13.54 ±6.05 years. All them had an excellent/good response OMA. 67.73 ±11.64 months.Nine out exacerbation...
BackgroundPatient-reported outcome measures (PROMs) are validated and standardized tools that complement physician evaluations guide treatment decisions. They crucial for monitoring atopic dermatitis (AD) chronic urticaria (CU) in clinical practice, but there unmet needs knowledge gaps regarding their use practice.ObjecctiveWe investigated the global real-world of AD CU PROMs allergology dermatology clinics as well associated local regional networks.MethodsAcross 72 specialized allergy...
BackgroundMepolizumab, an anti-interleukin-5 (IL-5) antibody, reduces disease flares in patients with hypereosinophilic syndrome (HES). Factors predicting treatment response are unknown.ObjectiveTo assess mepolizumab efficacy by baseline blood eosinophil count (BEC) and serum IL-5 level HES.MethodsThis post hoc analysis used data from the phase III study assessing HES (NCT02836496). Patients 12 years old or older, for 6 more months, 2 previous year, BEC ≥1,000 cells/μL at screening were...
Overestimation of asthma control remains a substantial healthcare issue. Overuse short-acting β2-agonists (SABA), one the aspects poor control, was highlighted by SABINA project as worldwide problem. The objective this study to investigate assessment and perception SABA role in therapy among Polish allergists, pulmonologists, general practitioners. included 253 practitioners.Data were gathered using qualitative questionnaire regarding physicians' practices opinions quantitative - an extended...
Summary Elevated homocysteine levels increase cardiovascular risk although the mechanism is not well understood. Since thrombosis plays an important role in plaque development and acute coronary syndromes, hyperhomocysteinemia may by increasing thrombotic potential. Hemostatic factors were measured 3216 individuals (1451 men 1765 women) free of disease who participated cycle 5 Framingham Offspring Study. An level was associated with a rise plasminogen activator inhibitor (PAI-1), tissue...
Background Two different regimens of subcutaneous immunotherapy (IT), perennial or preseasonal, may be used in the treatment seasonal allergy. The aim this study was to compare efficacy and safety IT (PIT) preseasonal (PSIT) patients suffering from rhinoconjunctivitis. Methods planned as a randomized, double-blind, comparative on PIT PSIT. group comprised 120 allergic grass rye pollen. After observational season they were randomized receive PSIT for 3 years. effect assessed based symptom...
Lipoxins represent a group of lipoxygenase derived eicosanoids which, in contrast to leukotrienes, are potent anti-inflammatory mediators. The aim our study was determine lipoxin A(4) (LXA(4)) and leukotriene C(4) (LTC(4)) levels nasal lavages after intranasal challenge with aspirin intolerant (AIA) comparison tolerant (ATA) asthmatics allergen patients suffering from allergic rhinitis.Twelve AIA, 8 ATA 20 were challenged placebo, 16 mg lysine-aspirin (Lys-ASA) or (grasses). Nasal collected...
Abstract Background Aspirin desensitization followed by daily aspirin use is an effective treatment for aspirin‐exacerbated respiratory disease (AERD). Objective To assess clinical features as well genetic, immune, cytological and biochemical biomarkers that might predict a positive response to high‐dose therapy in AERD. Methods We enrolled 34 AERD patients with severe asthma who underwent 52‐week (650 mg/d). At baseline at 52 weeks, assessment was performed; phenotypes based on induced...
<i>Background:</i> Although the long-term deterioration of lung function in asthmatic patients has been described, exact mechanism remains to be determined. <i>Objectives:</i> The aim this study was find correlations between age, sex, atopic status, duration asthma, asthma severity and decline pulmonary function. <i>Method:</i> medical histories 1,006 randomly chosen outpatients were studied retrospective data on duration, spirometry results, treatment...
H(1)-receptor antagonists are known to suppress reactions in skin-prick tests (SPTs); however, the effect of H(2)-receptor antagonists, which widely used our everyday practice, remains unclear. The aim this study was determine influence ranitidine on wheal, flare, and itching sensation SPTs. Twenty-one atopic patients (5 women 16 men) with an average age 28.04 years (SD, +/-8.24) were tested histamine, codeine, negative control solution, standard allergen extracts. Ranitidine (150 mg daily),...
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic diseases adults and a major cause morbidity mortality throughout world. It physical mental suffering for patient, significantly impairs quality life, reduces vital activity affects patient’s life in its various aspects. In 2012, nationwide survey was conducted COPD outpatients with history smoking exploring factors disease effects on health patient. The purpose analysis presented here to assess...