A5021901547- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Crystallization and Solubility Studies
- Microencapsulation and Drying Processes
- Analytical Chemistry and Chromatography
- Essential Oils and Antimicrobial Activity
- Pharmaceutical studies and practices
- Thermal and Kinetic Analysis
- Advanced Drug Delivery Systems
- Chemical Thermodynamics and Molecular Structure
- Public Health in Brazil
- Microbial Metabolites in Food Biotechnology
- Antibiotics Pharmacokinetics and Efficacy
- X-ray Diffraction in Crystallography
- Polysaccharides Composition and Applications
- Metal complexes synthesis and properties
- Freezing and Crystallization Processes
- Botanical Research and Applications
- Food composition and properties
- Probiotics and Fermented Foods
- Dermatology and Skin Diseases
- Phytochemistry and Biological Activities
- Herpesvirus Infections and Treatments
- Polymer Synthesis and Characterization
- Acne and Rosacea Treatments and Effects
Universidade Federal do Paraná
2014-2024
Instituto de Pesquisas Jardim Botânico do Rio de Janeiro
2011-2023
Universidade Estadual do Centro-Oeste
2014
Universidade Federal de Santa Catarina
2006-2013
Universidade Positivo
2009-2011
Calcium carbonate, a pharmaceutical excipient, is widely used as diluent in solid dosage forms. It also base for medicinal and dental preparations, buffering dissolution aid dispersible tablets, food additive calcium supplement. Egg shells are rich source of mineral salts, mainly which corresponds to about 94% the shell. Layer farms produce large amounts shells, whose final disposal poses challenge from environmental standpoint. This work was designed evaluate physicochemical thermal...
Eucalyptus cinerea, known as silver dollar tree, has few descriptions in traditional medicine. Chemical composition and antimicrobial properties of the essential oils leaves, flowers fruits, collected seasonally, were determined by GC/MS disk diffusion/MIC, respectively. 1,8-Cineole was main compound, particularly fresh leaves—Spring (74.98%), dried (85.32%), flowers—Winter (78.76%) fruits—Winter (80.97%). Other compounds found aerial parts all seasons: α-pinene (2.41% to 10.13%), limonene...
Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-4, used for treatment type 2 diabetes mellitus. The crystal structure active pharmaceutical solids determines their physical and chemical properties. polymorphism, solvates hydrates can influence free energy, thermodynamic parameters, solubility, solid-state stability, processability dissolution rate, besides directly affecting bioavailability. Thus, physicochemical characterization ingredient required to guarantee rational...
Goat's whey was submitted to two cycles of block freeze concentration process, resulting in concentrate 1 and 2. Concentrate added with 5 g inulin both concentrates were inoculated Bifidobacterium animalis ssp. lactis BB-12, the then denoted as feed solutions 2, respectively. Feed spray-dried, powder The stability bifidobacteria entrapped within powders evaluated for spray-dried stored at 4 °C 25 60 days. also relation their physical thermal properties. It noted that Bifidobacteria displayed...
A rapid and effective isocratic chromatographic procedure is successfully developed to determinate methotrexate (MTX) entrapment efficiency (EE) in polymeric nanocapsules using reversed-phase high-performance liquid chromatography. The method employed a RP-C18 Shimadzu Shim-pack CLC-ODS (150 mm × 4.6 mm, 5 µm) column with mobile phase constituted by mixture of water-acetonitrile-tetrahydrofuran (65:30:5 v/v/v; pH 3.0) at flow rate 0.8 mL/min. eluate monitored UV detector set 313 nm....
The aim of this study was to evaluate the chemical, antioxidant, and antimicrobial activity essential oils as well anatomy aerial parts from Baccharis aracatubaensis, burchellii, organensis owing therapeutic potential Baccharis. volatile constituents were analyzed using GC/MS, antioxidant evaluated by oxygen radical absorbance capacity (ORACFL ) DPPH assays, a microdilution technique. Of 56 compounds identified, only seven (β-caryophyllene, γ-muurolene, bicyclogermacrene, β-germacrene,...
Abstract An analytical method using a sensitive high performance liquid chromatographic technique was developed to quantify omeprazole in delayed release tablets. The analysis carried out RP‐C18 column with UV‐Vis detection at 280 nm. mobile phase diluted phosphate buffer (pH 7.4) and acetonitrile (70:30 v/v) flow‐rate of 1.5 mL·min−1. parameters used the validation process were: linearity, range, quantification limit, accuracy, specificity, precision. retention time about 5 min symmetrical...
In order for the pharmacological action of a topical dermal drug product to occur, must first be released from vehicle available penetrate skin layers and reach site action. Drug release is mainly dependent on characteristics formulation. Currently, register generic or similar in Brazil performance testing products local not required. this context, aim study was evaluate vitro commercial diclofenac diethylamine gel Brazilian pharmaceutical market, using vertical diffusion cell method....