A5101478189- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Management of metastatic bone disease
- Musculoskeletal synovial abnormalities and treatments
- Orthopaedic implants and arthroplasty
- Acute Myocardial Infarction Research
- Vascular Tumors and Angiosarcomas
- Cardiac Valve Diseases and Treatments
- Cancer Diagnosis and Treatment
- Botanical Studies and Applications
- Cerebrovascular and Carotid Artery Diseases
- Oral and Maxillofacial Pathology
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Spine and Intervertebral Disc Pathology
- Surgical site infection prevention
- Horticultural and Viticultural Research
- Fungal Biology and Applications
- Soft tissue tumors and treatment
- Mesenchymal stem cell research
- Orthopedic Infections and Treatments
Seoul National University
2014-2025
Seoul National University Hospital
2015-2025
Abbott (Switzerland)
2024
Bridge University
2024
Abbott (Germany)
2024
Griffith University
2022-2024
University Research Co (United States)
2024
University of Technology Sydney
2022
The University of Adelaide
2022
Weatherford College
2020-2021
Neuroprotective or regenerative strategies are invaluable in multiple system atrophy (MSA) due to its rapid progression with fatal prognosis. We evaluated the efficacy of autologous mesenchymal stem cells (MSC) patients MSA-cerebellar type (MSA-C).Thirty-three probable MSA-C and baseline unified MSA rating scale (UMSARS) scores ranging from 30 50 were randomly assigned receive MSC (4 × 10(7) /injection) via intra-arterial intravenous routes placebo. The primary outcome was change total...
Abstract The purpose of this review was to determine whether imatinib mesylate (STI571, Gleevec) has a role in the treatment osteosarcoma. expression platelet‐derived growth factor (PDGF) receptor and its ligand examined panel surgical specimens obtained from 54 osteosarcoma patients, then compared with prognosis. effects on molecular events 10 patient‐derived cell cultures were investigated. Immunohistochemical studies demonstrated frequent PDGF‐AA (80.4%) PDGF‐α (79.6%) their correlation...
Because of a lack an appropriate animal model system and the inaccessibility human oligodendrocytes in vivo, X-linked adrenoleukodystrophy (X-ALD)-induced pluripotent stem cells (iPSCs) would provide unique cellular for studying etiopathophysiology development therapeutics X-ALD.We generated characterized iPSCs 2 major types X-ALD, childhood cerebral ALD (CCALD) adrenomyeloneuropathy (AMN), differentiated them into neurons. We evaluated disease-relevant phenotypes by pharmacological genetic...
Background and Objectives The three‐dimensional (3D)‐printed bone tumor resection guide can be personalized for a specific patient utilized surgery. It is noninvasive, eidetic, easy to use. We aimed categorize the use of 3D‐printed establish in vivo accuracy data. Methods retrospectively reviewed 12 patients, who underwent limb salvage surgery using at single institution. To confirm achievement safe margin, we compared actual planned distances between cutting surface tumor, which were...
BACKGROUND: There is no appropriate alternative source of red blood cells (RBCs) to relieve the worsening shortage available for transfusion. Therefore, in vitro generation clinically RBCs from hematopoietic stem could be a promising new supplement supply. However, there have been few studies about clinical‐grade by coculture on human mesenchymal (MSCs) and various cytokine supplements, even though production pure requires stromal proper supplements. STUDY DESIGN AND METHODS: Umbilical cord...
Background:We present here the oncological and functional outcomes of limb salvage with or without reconstruction for primary sarcomas in pelvic bone.Methods: Forty-four patients who underwent resection involving pelvis were reviewed.The average follow-up period was 39 months (range, 0 to 146 months).Chondrosarcoma (n = 17) osteosarcoma 10) most common diagnoses.Various clinicopathologic factors analyzed relation overall survival local recurrence.The Musculoskeletal Tumor Society scores...
Open surgery is rarely justified for the initial treatment of a unicameral bone cyst, but there some debate concerning relative effectiveness closed methods. This study compared results steroid injection with those autologous marrow grafting cysts. Between 1990 and 2001, 30 patients were treated by 28 marrow. The overall success rates 86.7% 92.0%, respectively (p > 0.05). rate after procedure was 23.3% in group 52.0% receiving < 0.05), respective cumulative second injections 63.3%...
Abstract Background Recently, the navigation system has been introduced to orthopedic oncology. It can apply MRI and/or CT images intraoperative visualization. We performed navigation‐assisted limb salvage surgeries on patients with a malignant bone tumor of metaphysis long or iliac while preserving adjacent joint. Methods When preoperative chemotherapy was estimated be effective by imaging studies and residual remaining epiphysis expected more than 1 cm after resection 1–2 surgical margin,...
Purpose The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. aim this study was to analyze oncological outcomes and factors. Materials Methods A retrospective review performed on 125 consecutive patients who underwent surgery at our institution. Results Overall survival 91.6%±2.5%, 84.1%±3.8%, 84.1%±3.8% 5, 10, 15 years respectively. Among the histological types, dedifferentiated type showed worst (p < 0.001). As...
Abstract Most default mode network ( DMN ) studies in patients with amnestic mild cognitive impairment aMCI and Alzheimer's disease AD are based on the comparison of only two groups, namely controls. Information derived from comparing three normal, , simultaneously may lead us to better understand progression dementia. The purpose this study was evaluate functional connectivity continuum normal through . Differences were compared between groups using independent component analysis....
Aims This study aimed to compare the performance of survival prediction models for bone metastases extremities (BM-E) with pathological fractures in an Asian cohort, and investigate patient characteristics associated survival. Methods retrospective cohort included 469 patients, who underwent surgery BM-E between January 2009 March 2022 at a tertiary hospital South Korea. Postoperative was calculated using PATHFx3.0, SPRING13, OPTIModel, SORG, IOR models. Model assessed area under curve...
Background and Objectives Literature on surveillance for lung metastasis from giant cell tumor of bone (GCTB) is scarce. We aimed to develop one by determining: (1) the optimal schedule analyzing time‐to‐event data, taking into account predictive factors, (2) effective diagnostic modality. Methods A total 333 patients who underwent surgery GCTB were followed at least 2 years. All had chest radiography, 169 additional CT surveillance. Time cumulative incidence calculated, performance between...
A highly stereoselective and efficient asymmetric total synthesis of (+)-laurencin (1) has been accomplished from the known oxazolidinone 5 in 15 steps. The route features an internal alkylation to form oxocene 3 4 a novel use acetonitrile anion as two-carbon acetaldehyde equivalent for direct ketone 2 α-alkoxy amide 3.
Abstract Osteosarcoma is a malignant tumor of bone characterized by its high metastatic potential. For the development metastasis, activation matrix metalloproteinases (MMPs) required. A novel MMPs inhibitor, reversion inducing cysteine rich protein with Kazal motifs (RECK), known to down‐regulate and suppress invasive potential in many tumor‐derived cell lines some types tumors. The expression RECK role invasiveness have never been studied osteosarcoma. We examined mRNA osteosarcoma using...
Cho, Hwan Seong MD; Kang, Hyun Guy Kim, Han-Soo MD, PhD; Han, Ilkyu PhD Author Information