A5049963191- Bariatric Surgery and Outcomes
- Esophageal and GI Pathology
- Diet and metabolism studies
- Gastroesophageal reflux and treatments
- Body Contouring and Surgery
- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Obesity and Health Practices
- Obstructive Sleep Apnea Research
- Metabolism, Diabetes, and Cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Hernia repair and management
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Venous Thromboembolism Diagnosis and Management
- Clinical practice guidelines implementation
- Pancreatitis Pathology and Treatment
- Surgical Simulation and Training
- Diabetes Treatment and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University Hospital of Bern
2016-2025
University of Bern
2015-2025
Heidelberg University
2023-2024
University Hospital Heidelberg
2023-2024
University of Cologne
2024
Chirurgische Universitätsklinik Heidelberg
2024
Universitätsklinikum des Saarlandes
2023
Sana Klinikum Offenbach
2018
Swiss National Science Foundation
2016
Kantonsspital St. Gallen
2016
<h3>Importance</h3> Sleeve gastrectomy is increasingly used in the treatment of morbid obesity, but its long-term outcome vs standard Roux-en-Y gastric bypass procedure unknown. <h3>Objective</h3> To determine whether there are differences between sleeve and terms weight loss, changes comorbidities, increase quality life, adverse events. <h3>Design, Setting, Participants</h3> The Swiss Multicenter Bypass or Study (SM-BOSS), a 2-group randomized trial, was conducted from January 2007 until...
Objective: Laparoscopic sleeve gastrectomy (LSG) is performed almost as often in Europe laparoscopic Roux-Y-Gastric Bypass (LRYGB). We present the 3-year interim results of 5-year prospective, randomized trial comparing 2 procedures (Swiss Multicentre Or Sleeve Study; SM-BOSS). Methods: Initially, 217 patients (LSG, n = 107; LRYGB, 110) were to receive either LSG or LRYGB at 4 bariatric centers Switzerland. Mean body mass index all was 44 ± 11 kg/m2, mean age 43 5.3 years, and 72% female....
Abstract Purpose Most studies on surgical activity recognition utilizing artificial intelligence (AI) have focused mainly recognizing one type of from small and mono-centric video datasets. It remains speculative whether those models would generalize to other centers. Methods In this work, we introduce a large multi-centric multi-activity dataset consisting 140 videos (MultiBypass140) laparoscopic Roux-en-Y gastric bypass (LRYGB) surgeries performed at two medical centers, i.e., the...
Venous thromboembolism is an important cause of postoperative morbidity and mortality in bariatric surgery. Studies direct oral anticoagulants (DOACs) are not available this surgical field. The objective phase 1 clinical trial was to investigate pharmacokinetic pharmacodynamic (PK/PD) parameters rivaroxaban patients.In single-centre study, obese patients received single doses (10 mg) day prior 3 days after PK PD were assessed at baseline during 24 h drug ingestion.Six Roux-en-Y gastric...
Importance Venous thromboembolism (VTE) is a leading cause of morbidity and mortality after bariatric surgery. Clinical end point studies on thromboprophylaxis with direct oral anticoagulants in patients undergoing surgery are lacking. Objective To assess the efficacy safety prophylactic dose 10 mg/d rivaroxaban for both 7 28 days Design, Setting, Participants This assessor-blinded, phase 2, multicenter randomized clinical trial was conducted from July 1, 2018, through June 30, 2021,...
Cytomegalovirus (CMV) and acute rejection (AR) alone have been associated with an increased risk of graft loss in kidney transplantation. However, little is known about their association when both affect the transplant recipient.By using dynamic time-varying covariate approach to Cox-proportional hazards model, we retrospectively analyzed strength AR CMV disease on a single-center simultaneous pancreas-kidney population.Between January 1990 December 2000, 2,740 transplants were performed at...
Abstract Aims/hypothesis Post-bariatric hypoglycaemia is an increasingly recognised complication of bariatric surgery, manifesting particularly after Roux-en-Y gastric bypass. While hyperinsulinaemia established pathophysiological feature, the role counter-regulation remains unclear. We aimed to assess counter-regulatory hormones and glucose fluxes during insulin-induced postprandial in patients with post-bariatric bypass vs surgical non-surgical control individuals. Methods In this...
Aims: To investigate the effect of empagliflozin on glucose dynamics in individuals suffering from postbariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB). Methods: Twenty-two adults with PBH RYGB were randomized to 25 mg or placebo once daily over 20 days a randomized, double-blind, placebo-controlled, crossover trial. The primary efficacy outcome was amplitude plasma excursion (peak nadir) during mixed-meal tolerance test (MMTT). Outcomes outpatient period assessed using...
The aim of this study was to evaluate the efficacy tropisetron, a selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, versus placebo in prevention postoperative nausea and vomiting patients undergoing general anesthesia for gynecologic surgery. Ten minutes before induction anesthesia, 80 received double-blind manner single intravenous (IV) injection either 5 mg tropisetron or matching placebo. Anesthesia induced with thiopental maintained nitrous oxide enflurane oxygen. In...