A5037734353- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Hepatitis B Virus Studies
- Dermatology and Skin Diseases
- Respiratory viral infections research
- NF-κB Signaling Pathways
- Hepatitis C virus research
- Cytokine Signaling Pathways and Interactions
- Single-cell and spatial transcriptomics
- Systemic Lupus Erythematosus Research
- vaccines and immunoinformatics approaches
- Toxoplasma gondii Research Studies
- Autophagy in Disease and Therapy
- Immunodeficiency and Autoimmune Disorders
- Phagocytosis and Immune Regulation
- Whipple's Disease and Interleukins
- Hepatitis Viruses Studies and Epidemiology
- RNA Interference and Gene Delivery
Technical University of Munich
2014-2024
Klinikum rechts der Isar
2014-2024
DKFZ-ZMBH Alliance
2020
Heidelberg University
2020
Helmholtz Zentrum München
2014-2016
Institute of Medical Microbiology and Hygiene
2009
Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown to enhance pathogen clearance by recruiting circulating immune providing bystander activation. Here, we characterize the functioning brain-resident (bTRM) in an animal model viral infection. bTRM were subject spontaneous homeostatic proliferation largely refractory systemic cell depletion. After reinfection mice, rapidly acquired cytotoxic effector function prevented fatal brain infection, even...
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which water-channel protein AQP4 target antigen
Abstract Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in various preclinical cancer models and correlates with adverse outcomes. However, as to how IL-23 fuels unclear. Here, we found tumor-associated macrophages be the main source of mouse human microenvironments. Among IL-23-sensing cells, identified subset tumor-infiltrating regulatory T (T reg ) display highly suppressive phenotype across tumors. The use three solid...
Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. Here, we establish transcriptional signature of central nervous system (CNS) that accumulate during experimental autoimmune encephalitis (EAE) identify pathway maintains function severe inflammation. This is dependent on the regulator Blimp1, which prevents downregulation Foxp3 expression "toxic" gain-of-function CNS....
Tissue-resident memory CD8+ T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support programming TRM cell fate tissue-infiltrating cells. Recent evidence suggests that TCR signals received infected tissues additionally contribute formation. Here, we asked how antigen-dependent pathways influence generation skin-resident arise from polyclonal repertoire induced by infection with...
Resolved brain virus infection early in life leaves persisting chemotactic cues that foster autoimmunity adulthood.
Abstract γδT17 cells are a subset of γδ T committed to IL-17 production and characterized by the expression IL-23R CCR6 lack CD27 expression. believed arise within narrow time window during prenatal thymic development. In agreement with this concept, we show in study that adult Rag1−/− recipient mice Il23rgfp/+ (IL-23R reporter) bone marrow selectively IL-23R+ cells. Despite their absence secondary lymphoid tissues homeostasis, emerge chimeric upon induction skin inflammation topical...
ABSTRACT CD4 + T lymphocytes play a central role in the immune system and mediate their function after recognition of respective antigens presented on major histocompatibility complex II (MHCII) molecules antigen-presenting cells (APCs). Conventionally, phagocytosed are loaded MHCII for stimulation cells. Certain epitopes, however, can be processed directly from intracellular (endogenous presentation). Here we characterized antigen presentation pathways that possibly involved response upon...
In certain instances, Th17 responses are associated with severe immunopathology. T cell–intrinsic mechanisms that restrict pathogenic effector functions have been described for type 1 and 2 but less well studied cells. Here, we report a cell-intrinsic feedback mechanism controls the pathogenicity of cells produce IL-24, which prompts them to secrete IL-10. The IL-10–inducing function IL-24 is independent cell surface receptor on Rather, recruited inner mitochondrial membrane, where it...
Natalizumab blocks α4-integrins and is a prototypic agent for series of anti-inflammatory drugs that impair trafficking immune cells into the CNS. However, modulation access to CNS associated with impaired surveillance detrimental viral infections Here, we explored potency cellular responses within protect against encephalitis in mice T cell conditional disruption VLA-4 integrin (α4β1) expression. While expression virus specific Th1 non-redundant their ability CNS, α4-integrin deficient Th17...
•LCMV infection activates NF-κB signaling in hepatocytes.•Macrophages, TNFR1 do not induce LCMV-driven hepatocyte NF-κB-activation.•IkkβΔHep mice display increased viral infection/replication and lower ISG induction.•IfnarΔHep recapitulate aberrant virus replication as observed IkkβΔHep mice.•NF-κB is required for efficient induction HBV-/HDV-infected HepaRG. Background & AimsHepatic innate immune control of infections has largely been attributed to Kupffer cells, the liver-resident...
Constitutive activation of the MALT1 paracaspase in conventional T cells Malt1TBM/TBM (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation and autoimmunity, but involved targets underlying molecular mechanisms are unknown. We genetically rendered a single substrate, RNA-binding protein (RBP) Roquin-1, insensitive to cleavage. These Rc3h1Mins/Mins showed normal immune homeostasis. Combining alleles with those encoding for constitutively active (TBM) prevented spontaneous cell restored...
Abstract For the efficient stimulation of T cells by tumor Ag, tumor-derived material has to be presented dendritic (DC). This very likely involves uptake dead DC. Cell death in tumors often occurs through apoptosis, but necrotic cell may also prevalent. distinction is relevant because numerous studies have proposed that apoptotic immunosuppressive effects while necrosis stimulatory. However, a system been lacking would allow induction apoptosis or without side stimuli used experimentally....
BCL10/MALT1 signaling in keratinocytes is altered human sporadic psoriasis and a critical initiator amplifier of skin inflammation mouse models.
Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver macrophages. However, also hepatocytes, parenchymal cells liver, possess potent immunological functions in addition their known metabolic functions. Owing abundance and functions, we aimed investigate direct anti-viral mechanisms employed by hepatocytes.
Here, we investigate the potential of CD70 co-expression during viral vector boost vaccination to improve an antigen-specific T cell response. To determine chance activating cells by CD70, used HBV core antigen as a model in heterologous protein-prime, Modified Vaccinia virus Ankara (MVA) scheme. Both and expression cassette were co-expressed upon delivery MVA under same promoter linked P2A site. compare immunogenicity with without co-expression, HBV-naïve, C57BL/6 (wt) mice HBV-transgenic...