A5068525379- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Single-cell and spatial transcriptomics
- Multiple Myeloma Research and Treatments
- Erythrocyte Function and Pathophysiology
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Psoriasis: Treatment and Pathogenesis
- Whipple's Disease and Interleukins
- Neonatal Health and Biochemistry
- Dermatology and Skin Diseases
Ludwig-Maximilians-Universität München
2018-2024
Technical University of Munich
2021-2022
Klinikum rechts der Isar
2021
Center for Integrated Protein Science Munich
2018-2019
Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. Here, we establish transcriptional signature of central nervous system (CNS) that accumulate during experimental autoimmune encephalitis (EAE) identify pathway maintains function severe inflammation. This is dependent on the regulator Blimp1, which prevents downregulation Foxp3 expression "toxic" gain-of-function CNS....
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm resulting from the malignant transformation of progenitors. Despite intensive chemotherapy leading to initial treatment responses, relapse caused by intrinsic or acquired drug resistance represents a major challenge. Here, we report that histone 3 lysine 27 demethylase KDM6A (UTX) targeted inactivating mutations and mutation-independent regulation in relapsed AML. Analyses matched diagnosis specimens individuals with showed...
The acquisition of mesenchymal traits is considered a hallmark breast cancer progression. However, the functional relevance epithelial-to-mesenchymal transition (EMT) remains controversial and context dependent. Here, we isolate epithelial populations from human metastatic biopsies assess their potential in vivo. Strikingly, progressively decreasing cell adhesion molecule (EPCAM) levels correlate with declining disease propagation. Mechanistically, find that persistent EPCAM expression marks...
In certain instances, Th17 responses are associated with severe immunopathology. T cell–intrinsic mechanisms that restrict pathogenic effector functions have been described for type 1 and 2 but less well studied cells. Here, we report a cell-intrinsic feedback mechanism controls the pathogenicity of cells produce IL-24, which prompts them to secrete IL-10. The IL-10–inducing function IL-24 is independent cell surface receptor on Rather, recruited inner mitochondrial membrane, where it...
Abstract Despite important advances in the treatment of breast cancer, 5-year survival rate for patients with distant metastasis remains less than 30%. Metastasis is a complex, multi-step process beginning local invasion and ending outgrowth systemically disseminated cells into actively proliferating metastases that ultimately cause destruction vital organs. It this last step limits patient and, at same time, least understood mechanistically. Here, we focus on understanding determinants...