A5047786019- RNA modifications and cancer
- Cancer-related gene regulation
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Influenza Virus Research Studies
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Neurological diseases and metabolism
- Sustainable Building Design and Assessment
- Biochemical and Molecular Research
- Mycobacterium research and diagnosis
- Bacterial Genetics and Biotechnology
- Medical Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Orthopaedic implants and arthroplasty
- RNA and protein synthesis mechanisms
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Bone health and osteoporosis research
- thermodynamics and calorimetric analyses
- Plant biochemistry and biosynthesis
- Antimicrobial Resistance in Staphylococcus
- Tea Polyphenols and Effects
Yale University
2022-2025
ShenZhen People’s Hospital
2023-2025
Texas A&M University
2017-2024
Jinan University
2018-2023
Southern University of Science and Technology
2022-2023
Middlemore Hospital
2022
Auckland City Hospital
2022
Shenzhen Sixth People's Hospital
2022
Beijing University of Posts and Telecommunications
2015
Chengdu Institute of Biology
2012
Emerging evidence suggests that the propagation of oral squamous cell carcinoma (OSCC) is influenced by abnormal expression microRNAs (miRNAs). This study aimed to characterize involvement miR-182-5p in OSCC targeting calcium/ calmodulin-dependent protein kinase II inhibitor CAMK2N1.miR-182-5p was quantified tissues and lines with reverse transcription polymerase chain reaction (RT-PCR). Cell colony formation, Counting Kit-8 (CCK-8), Ki-67, nude mouse xenograft assays were used role...
SARS-CoV-2 Mpro inhibitors, such as nirmatrelvir, have proven efficacy in clinical use. Nirmatrelvir was developed a target-based approach against wild-type Mpro, with the anticipation that prolonged usage may cause enrichment of drug-resistant mutations and persistence COVID infections. Although globally prevalent not yet been observed, individual cases recently reported among patients following treatment Paxlovid-a formulation nirmatrelvir. Mutations E166V E166A detected these isolates,...
Fluconazole, a widely used antifungal agent, has been associated with various adverse events (AEs). This study aimed to analyze the safety profiles of fluconazole using FDA Adverse Event Reporting System (FAERS) database provide insights for its safe use. Fluconazole-related AEs from 2004 2024Q2 were extracted FAERS database. The Odds Ratio (ROR) method was employed detect and signals. Additionally, impact COVID-19 on also examined. A total 7,720 identified, 40.3% being serious. most common...
The pathogenicity of Mycobacterium tuberculosis depends upon its ability to catabolize host cholesterol. Upregulation the methylcitrate cycle (MCC) is required assimilate and detoxify propionyl-CoA, a cholesterol degradation product. transcription key genes prpC prpD in MCC activated by MtPrpR, member family prokaryotic factors whose structures modes action have not been clearly defined. We show that MtPrpR has novel overall structure directly binds CoA or short-chain acyl-CoA derivatives...
The seed of Cuscutae Semen has been used as a functional food to prevent osteoporosis and aging, improve sexual function in Traditional Chinese Medicine. However, there is little report on its beneficial effects osteoporosis. purpose our study was explore whether polysaccharide (CSP) could induced by estrogen deficiency the ovariectomized rat model. preventive effect CSP assessed using (OVX) model treatment with vehicle or for 12 weeks. Serum indexes related osteogenesis were measured ELISA...
YTH domain containing 1 (YTHDC1), an N6-methyladenosine (m6A) modification reading protein, plays a key role in regulating RNA translation and degradation. However, the of YTHDC1 head neck squamous cell carcinoma (HNSCC) cancer stem cells remains largely unknown. This study is aimed at investigating HNSCC exploring its cells. sequencing was used to detect differentially expressed genes (DEGs) between SCC9 spheres uncover molecular pathways target molecules associated with CSCs. We detected...
APOBEC3 family members are cytidine deaminases catalyzing conversion of to uracil. Many studies have established a link between expression and cancer development progression, especially APOBEC3A (A3A) APOBEC3B (A3B). Preclinical with human papillomavirus positive (HPV+) head neck squamous cell carcinoma (HNSCC) clinical trial specimens revealed induction A3B, but not A3A after demethylation. We examined the kinetic features deaminase activity for full length A3B found that longer substrates...
Background. Transforming growth factor β1-activated kinase 1 binding protein 2 (TAB2) mediates a variety of biological processes through activated nuclear κ-light-chain-enhancer B cell (NF-κB) signaling pathways. TAB2 has been reported to be upregulated in tumors. However, little is known about its potential role oral squamous carcinoma (OSCC). Material and Methods. Patients’ clinicopathological transcription data were obtained from The Cancer Genome Atlas (TCGA) database....
Recently, the biosynthetic pathway for lycopadiene, a C40 tetraterpenoid hydrocarbon, was deciphered from L race of Botryococcus braunii, an alga that produces hydrocarbon oils capable being converted into combustible fuels. The lycopadiene is initiated by squalene synthase (SS)-like enzyme lycopaoctaene (LOS), which catalyzes head-to-head condensation two C20 geranylgeranyl diphosphate (GGPP) molecules to produce lycopaoctaene. LOS shows unusual substrate promiscuity SS or SS-like enzymes...
Peri-implant tissue inflammation is an inflammatory injury that occurs in the soft and hard tissues surrounding implant main cause of short- or long-term failure prosthetic restorations, which compounded by bone loss destruction alveolar diabetes patients with peri-implantitis. However, mechanisms underlying persistence diabetic peri-implantitis, as well essential connections key molecules regulate its start progression, remain unknown. In this study, we discovered M1 macrophage polarization...
Phosphopantetheinyl hydrolase, PptH (Rv2795c), is a recently discovered enzyme from Mycobacterium tuberculosis that removes 4'-phosphopantetheine (Ppt) holo-carrier proteins (CPs) and thereby opposes the action of phosphopantetheinyl transferases (PPTases). first structurally characterized hydrolase family. However, conditions for optimal activity have not been defined, only one substrate has identified. Here, we provide biochemical characterization demonstrate hydrolyzes Ppt
Objective To explore the value of tuberculosis mycobacterium positive rate fiber bronchoscope brush piece degree PPD patients. Methods Apply check for 150 patients who were admitted into hospital during August 2013 to 2015.They divided weakly positive, strong and blisters positive.The was recorded analyzed. Results The detected in cases.28 weak-positive cases with bronchoscopy TB 3.57%.76 3.95%.42 strong-positive 14.28%.4 75.00%. Conclusions The staining blister is high,...
Objective To establish a mouse model for the potency test of BCG polysaccharide nucleic acid (BCG-PSN) preparation.Methods Pig serum,bovine serum albumin (BSA) and ovalbumin were chosen as allergens.BALB/c mice inoculated intraperitoneally with pig serum,BSA or to an animal type Ⅰ allergy.The feasibility established was validated by application in BCG-PSN preparation.The statistical analysis results made t test.Results could be used allergens sensitize BALB/c mice,but sensitization BSA...
Abstract Head and neck squamous cell carcinoma (HNSCC) is the most prevalent malignant tumor of maxillofacial area. Carcinogenesis might be fueled by abnormal activation central cell-cycle machinery dysregulation protein production. ARGs (autophagy-related genes) are involved in cycle translation. In HNSCC, however, involvement during translation has yet to discovered. this study, we focused on ARG hallmark's prognosis HNSCC patients. According TCGA data, ATG5 was shown an adverse prognostic...
Abstract Introduction Head and neck squamous cell carcinoma (HNSCC) is the most prevalent malignant tumor of maxillofacial area. ARGs (autophagy-related genes) are involved in cycle translation, which will fuel carcinogenesis. Material methods TCGA data for HNSCC were analyzed. The functional role ATG5 was investigated through knockdown lines. Results According to data, shown be an adverse prognostic marker. Regardless stage, grade, or clinical characteristics, patients with high expression...