A5061479278- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Pregnancy and preeclampsia studies
- Long-Term Effects of COVID-19
- Blood properties and coagulation
- Acute Myeloid Leukemia Research
- Parkinson's Disease Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Kruppel-like factors research
- Cardiovascular Disease and Adiposity
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Artificial Intelligence in Healthcare
- Atherosclerosis and Cardiovascular Diseases
- Spondyloarthritis Studies and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Mechanical Circulatory Support Devices
- Hematological disorders and diagnostics
University College Dublin
2019-2025
Brigham and Women's Hospital
2025
Harvard University
2025
Conway School of Landscape Design
2023-2024
Mater Misericordiae University Hospital
2024
Sciences, Philosophie, Histoire
2023
Royal College of Surgeons in Ireland
2021
University Hospital Cologne
2017-2018
Swiss Insurance Association
2017
University of Alabama at Birmingham
2002
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), has affected over 30 million globally to date. Although high rates of venous thromboembolism and evidence COVID-19-induced endothelial dysfunction have been reported, precise aetiology increased thrombotic risk associated with COVID-19 infection remains be fully elucidated. Therefore, we assessed clinical platelet parameters circulating activity in patients severe nonsevere COVID-19. An...
Hypercoagulability and endothelial dysfunction are hallmarks of coronavirus disease 2019 (COVID-19) appear to predict severity. A high incidence thrombosis despite thromboprophylaxis is reported in patients with moderate severe COVID-19. Recent randomized clinical trials suggest that therapeutic-intensity heparin confers a survival benefit moderate-severity COVID-19 compared standard-intensity heparin, potentially by harnessing heparin-mediated endothelial-stabilizing anti-inflammatory...
To date, coronavirus disease 2019 (COVID-19) has affected over 100 million people globally. COVID-19 can present with a variety of different symptoms leading to manifestation ranging from mild cases life-threatening condition requiring critical care-level support. At present, rapid prediction severity and care requirement in patients, early stages disease, remains an unmet challenge. Therefore, we assessed whether parameters routine clinical hematology workup, at the time hospital admission,...
Extracorporeal Photopheresis (ECP) is a leukapheresis based treatment for Cutaneous T-Cell Lymphoma, which takes advantage of the cellular lethal effects UVA light in combination with photoactivated drug, 8-methoxypsoralen. 25% patients treated ECP do not respond to treatment, however underlying mechanisms this lack response remain unknown. Platelets, rich source extracellular vesicles (EVs) and key mediators thromboinflammatory oncological progression, as well leukocytes, are both processed...
Abstract Background Venous thromboembolism (VTE) remains a significant cause of morbidity and mortality worldwide. Rivaroxaban, direct oral factor Xa inhibitor, mediates anti‐inflammatory cardiovascular‐protective effects besides its well‐established anticoagulant properties; yet, these remain poorly characterized. Extracellular vesicles (EVs) are considered proinflammatory messengers regulating myriad (patho)physiological processes may be highly relevant to the pathophysiology VTE. The...
ABSTRACT Purpose Multiple Sclerosis is an inflammatory neurodegenerative disease characterised by blood‐brain barrier dysfunction and leukocyte infiltration into the CNS. Platelets are best known for their contributions to haemostasis, however, upon activation, platelets release abundance of soluble vesicular‐associated proteins, termed platelet releasate (PR). This milieu contains numerous vasoactive that can attract leukocytes alter endothelial permeability. Experimental design We aimed...
Objective Clinical recruitment encompasses a significant challenge in multidisciplinary research, often acting as bottleneck to timely completion due slower-than-expected patient enrolment rates. Addressing this, enhanced communication within clinical departments is crucial. A quality improvement (QI) study was initiated the Mater Misericordiae University Hospital (MMUH) increase slow rate of cancer-associated thrombosis patients EXPECT Study. Methods Process and stakeholder mapping well...
ABSTRACT There is growing interest in the role of extracellular vesicles (EVs) neonatal pathology. This study aimed to characterise circulating EVs following preterm birth. single‐centre prospective observational included cord and postnatal plasma from ( n = 101) full‐term infants 66). were analysed using nanoparticle tracking analysis, flow cytometry, proteomics procoagulant activity assay. We found changes concentration, size, cellular origin proteomic content during perinatal adaptation....
ABSTRACT Introduction Cancer patients face a 4 to 7‐fold higher risk of developing thrombotic events compared individuals without cancer. This elevated is driven by the underlying tumour biology and effects cancer treatments, significantly increasing mortality rates these patients. While low molecular weight heparin (LMWH) gold standard anticoagulation, direct oral anticoagulants (DOACs) are emerging as effective alternatives. Recent clinical evidence indicates reduced recurrent VTE upon...
Traumatic brain injury (TBI) is a global health priority. In addition to being the leading cause of trauma related death, TBI can result in long-term disability and loss health. Disorders haemostasis are common despite absence some traditional risk factors for coagulopathy following trauma. Similar induced coagulopathy, this manifests with biphasic response consisting an early hypocoagulable phase delayed hypercoagulable state. This clinically significant associated increased rates...
ObjectiveThe aim of this study was to evaluate infants, born women with SARS-CoV-2 detected during pregnancy, for evidence haematological abnormalities or hypercoagulability in umbilical cord blood.Study designThis a prospective observational case-control infants who had RNA by PCR at any time their pregnancy (n = 15). The carried out Tertiary University Maternity Hospital (8,500 deliveries/year) Ireland. This approved the Research Ethics Committee and written consent obtained. Umbilical...
Abstract Background Coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has to date affected over 13.3 million globally. Although high rates of venous thromboembolism and evidence COVID-19-induced endothelial dysfunction have been reported, the precise aetiology increased thrombotic risk associated with COVID-19 infection remains be fully elucidated. Objectives Here, we assessed clinical platelet parameters circulating activity in patients severe non-severe COVID-19....
The contents of the platelet releasate (PR) play significant roles in hemostasis, inflammation, and pathologic sequelae. Careful isolation to ensure quiescence subsequent activation is key successful generation PR. Here, we describe steps isolate aggregate quiescent washed platelets from whole blood a clinical patient cohort. We then detail PR isolated human under conditions. This protocol allows investigation cargoes released through various pathways.