A5075947989- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Streptococcal Infections and Treatments
- Lipid Membrane Structure and Behavior
- Diffusion and Search Dynamics
- Escherichia coli research studies
- Bacterial biofilms and quorum sensing
- Otolaryngology and Infectious Diseases
- Animal Nutrition and Physiology
- Orthopedic Infections and Treatments
- Bacterial Infections and Vaccines
- CAR-T cell therapy research
- Entomological Studies and Ecology
- Immune Response and Inflammation
- bioluminescence and chemiluminescence research
- Maternal Mental Health During Pregnancy and Postpartum
- Medicinal Plants and Neuroprotection
- Polyamine Metabolism and Applications
- Neuroendocrine regulation and behavior
- Gene Regulatory Network Analysis
- Legume Nitrogen Fixing Symbiosis
- T-cell and B-cell Immunology
- Microbial Metabolic Engineering and Bioproduction
- Biopolymer Synthesis and Applications
- Cell Image Analysis Techniques
Pediatric Infectious Diseases Society
2024
Agency for Healthcare Research and Quality
2023
Allergan (Ireland)
2023
Pfizer (Ireland)
2023
Ludwig-Maximilians-Universität München
2018-2023
Baylor College of Medicine
2019-2023
Nabriva Therapeutics (Austria)
2023
Texas Children's Hospital
2020
Houston Methodist
2020
Methodist Hospital
2020
Background: The Streptococcus anginosus group (SAG) pathogens have the potential to cause head and neck space infections, including intracranial abscesses. Several centers noted an increase in abscesses children during SARS-CoV-2 pandemic, prompting a Centers for Disease Control Prevention health alert May 2022. We examined epidemiology of pediatric at tertiary care center with focus on SAG pre- post-pandemic. Methods: Cases any microbiologic etiology admitted from January 2011 December 2022...
Transgenic coexpression of a class I-restricted tumor antigen-specific T cell receptor (TCR) and CD8αβ (TCR8) redirects antigen specificity CD4+ cells. Reinforcement biophysical properties early TCR signaling explain how redirected cells recognize target cells, but the transcriptional basis for their acquired antitumor function remains elusive. We, therefore, interrogated human CD8+ by single-cell RNA sequencing characterized them experimentally in bulk assays mouse xenograft model. TCR8...
Abstract All living cells have a large number of proteins that are anchored with one transmembrane helix in the cytoplasmic membrane. Almost nothing is known about their spatiotemporal organization whole cells. Here we report on localization and dynamics representative, pH sensor transcriptional regulator CadC Escherichia coli . Fluorophore-tagged was detectable as distinct cluster only when receptor activated by external stress, which results DNA-binding. Clusters immediately disappeared...
SignificanceHost-emitted stress hormones significantly influence the growth and behavior of various bacterial species; however, their cellular targets have so far remained elusive. Here, we used customized probes quantitative proteomics to identify target epinephrine α-adrenoceptor agonist phenylephrine in live cells aquatic pathogen Vibrio campbellii. Consequently, discovered coupling protein CheW, which is center chemotaxis signaling network, as a both molecules. We not only demonstrate...
Bacteria have evolved different systems to sense and adapt acid stress. For example, Vibrio campbellii, a marine pathogen for invertebrates, encounters acidic conditions in the digestive glands of shrimp. The main resistance system V. campbellii is Cad system, which activated when cells are low-pH, amino acid-rich environment. consists pH-responsive transcriptional activator CadC, lysine decarboxylase CadA, lysine/cadaverine antiporter CadB. In many species, LysR-type regulator AphB involved...
Bacteria have evolved different signaling systems to sense and adapt acid stress. One of these systems, the CadABC-system, responds a combination low pH lysine availability. In
Abstract Strains of the Gram-negative bacterium Vibrio coralliilyticus cause bleaching corals due to decomposition symbiotic microalgae. The V. strain ATCC BAA-450 (Vc450) encodes a type III secretion system (T3SS). gene cluster also protein (locus tag VIC_001052) with sequence homology T3SS-secreted nodulation proteins NopE1 and NopE2 Bradyrhizobium japonicum (USDA110). VIC_001052 has been shown undergo auto-cleavage in presence Ca 2+ similar NopE proteins. We have studied hitherto unknown...
Membrane proteins account for about one third of the cellular proteome, but it is still unclear how dynamic they are and establish functional contacts with cytoplasmic interaction partners. Here, we consider a membrane-integrated one-component receptor that also acts as transcriptional activator, analyze kinetically locates its specific binding site on genome. We focus case CadC, pH acid stress response Cad system in E. coli . CadC prime example signaling protein directly binds to cognate...
Geprüft wurde das Verhalten des Plasmafibronectins im Verlauf der normalen Schwangerschaft ab dem zweiten Trimenon, post partum, aus Nabelschnurblut sowie bei Fällen mit EPH-Gestose. Als Kontrollgruppe dienten nichtschwangere Frauen einer vergleichbaren Altersgruppe.
Abstract Background The Streptococcus anginosus group (SAG) pathogens (S. anginosus, S. intermedius, and constellatus) are oral flora with the potential to cause head neck space infections including brain abscesses. Several centers noted an increase in intracranial abscesses children SARS-CoV-2 era, prompting a CDC health alert May 2022. Notably, large proportion of such reported cases were associated SAG and/or sinusitis. We examined epidemiology pediatric focus on pre- post-pandemic...
In addition to their well-known role as stress-associated catecholamine hormones in animals and humans, epinephrine (EPI) norepinephrine (NE) act interkingdom signals between eukaryotic hosts bacteria. However, the molecular basis of effects on bacteria is not well understood. initial phenotypic studies utilizing Vibrio campbellii a model organism, we characterized bipartite mode action catecholamines, which consists promotion growth under iron limitation, enhanced colony expansion soft...
Zusammenfassung Die Unrersuchungen an legenden Hühnern über die Speicherung und Ausscheidung von Vitamin A nach ungenügender Vitamin‐A‐Versorgung haben ergeben: 1. Der Umfang des Vitamin‐A‐Depots wird wesentlich vom Vorrat in der Leber bestimmt. Eine Ablagerung größerer Vitamin‐A‐Mengen Ovar, Lunge, Niere, Milz, Dünndarm Fettgewebe findet nicht statt. 2. Aus dem Leber‐Depot werden den ersten 8 Wochen ≅ 90 % Vitamins mobilisiert, wobei es zu keiner Verlagerung kommt. Nach 16 ist alien Organen...
Zusammenfassung Nach parenteraler Zufuhr von Vitamin B 12 bei legenden Hennen wurde eine Steigerung des Lecithingehaltes Eidotters beobachtet. Der nicht immer gleichmäßige Einfluß wird u. a. mit dem Umfang der bakteriellen Synthese in den Blinddärmen Zusammenhang gebracht. Summary The effect of vitamin on the lecithin content egg yolk Parenteral administration to laying hens was followed by a rise yolk. That not always constant may be due microbial synthesis caeca. Résumé L'action de la...
Abstract Membrane proteins account for about one third of the cellular proteome, but it is still unclear how dynamic they are and establish functional contacts with cytoplasmic interaction partners. Here, we consider a membrane-integrated one-component receptor that also acts as transcriptional activator, analyze kinetically locates its specific binding site on genome. We focus case CadC, pH acid stress response Cad system in E. coli. CadC prime example signaling protein directly binds to...
In addition to their well-known role as stress-associated catecholamine hormones in animals and humans, epinephrine (EPI) norepinephrine (NE) act interkingdom signals between eukaryotic hosts bacteria. However, the molecular basis of effects on bacteria is not well understood. initial phenotypic studies utilizing Vibrio campbellii a model organism, we characterized bipartite mode action catecholamines, which consists promotion growth under iron limitation, enhanced colony expansion soft...
Abstract Background Acute hematogenous osteomyelitis (AHO) is a serious infection in children. ESPID guidelines recommend empiric therapy with antistaphylococcal β-lactams regions low methicillin-resistant S. aureus (MRSA) prevalence. In areas moderate-high prevalence of MRSA, selection can be more challenging. We sought to examine factors present at the time admission which may predict etiology and guide treatment pediatric AHO region endemic MRSA. Methods reviewed admissions ICD9/10 codes...