A5100781095- Sperm and Testicular Function
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related molecular mechanisms research
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Sexual Differentiation and Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Air Quality and Health Impacts
- DNA Repair Mechanisms
- Prenatal Screening and Diagnostics
- Ophthalmology and Visual Impairment Studies
- Smart Materials for Construction
- Autophagy in Disease and Therapy
- Cancer-related cognitive impairment studies
- Proteoglycans and glycosaminoglycans research
- Nuclear Structure and Function
- Aldose Reductase and Taurine
- Coenzyme Q10 studies and effects
- Connexins and lens biology
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
Xi'an Jiaotong University
2014-2024
Institute of Genetics and Developmental Biology
2020-2023
Ministry of Education of the People's Republic of China
2011-2021
Cleveland Clinic
2013
BACKGROUND:Increasing evidence indicates that long noncoding RNAs (LncRNAs) play a key role in multiple pathological processes. It has been shown LncRNA steroid receptor RNA activator (SRA) is elevated peripheral blood of patients with polycystic ovary syndrome (PCOS). The aim this study was to assess the effect SRA on ovarian granular cells mice vitro. MATERIAL AND METHODS:We firstly isolated from mouse ovaries and over-expressed by means lentiviral transfection cell line. Then, we assessed...
Non-obstructive azoospermia (NOA) is a multifactorial disorder whose molecular basis remains largely unknown. Circular RNAs (CircRNAs), novel class of endogenous RNAs, have been recognized to play important roles in many biological processes. However, little known about the expression patterns and functions circRNAs human testes involved NOA.In this study, testicular circRNA profile were explored NOA patients controls by high-throughput microarray. Real-time quantitative reverse...
Non-obstructive azoospermia (NOA), identified in approximately 10% of infertile males, is a multifactorial disease whose molecular mechanisms remain unknown.The aim this study was to identify the role hsa_circ_0000116 NOA and illustrate its predictive value testicular sperm retrieval.The included 78 individuals, 58 with 20 obstructive (OA). Serum hormones including testosterone (T), follicle-stimulating hormone (FSH), luteinizing (LH), prolactin (PRL), estradiol II (E2) were measured....
The epithelial-mesenchymal transition (EMT) is crucial for cancer progression. Evidence has shown that miR-22 and miR-214 play a key role in colon progression; however, the underlying mechanism remains to be known. effects of on EMT are contradictory different cancers, whether involved process needs elucidated. In this study, we evaluated exact regulation cancer. After transfection with expression vector, cell proliferation migration capacity HCT116 RKO cells were significantly suppressed....
To study the incidence of single nucleotide polymorphisms in ubiquitin-specific protease 26 (USP26) gene and its involvement idiopathic male infertility China.Routine semen analysis was performed. Infertility factors such as immunological, infectious biochemical disorders were examined to select patients with infertility. DNA isolated from peripheral blood selected control population, which for mutations using polymerase chain reaction-single strand conformation polymorphism analysis....
Oral squamous cell carcinoma (OSCC) cells are usually resistant to doxorubicin, resulting in limited application of doxorubicin OSCC treatment. MicroRNA (miR)‑221 has been reported be involved the development OSCC; however, it remains unclear if and how miR‑221 is implicated modulating sensitivity doxorubicin. In present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used assess expression response addition, SCC4 SCC9 lines were transfected with...
Objective: To investigate the cumulative live birth rates (CLBR) according to body mass index (BMI) in women undergoing first vitro fertilization (IVF). Design: Retrospective cohort analysis. Setting: An IVF clinic a public hospital. Patients: This is retrospective study of 14782 patients fresh cycles with subsequently frozen embryo transfer during Jan 2014-Jan 2017 our clinic. The follow-up continued for CLBR until 2019. Patients BMI 24 kg/m2 were considered be overweight (Obese ≥28 kg/m2)....
Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Our previous study revealed that circular RNA (circRNA)-FOXO3 highly expressed in and inhibits proliferation. However, to best our knowledge, at present, no has focused on specific mechanism circRNA-FOXO3 drug resistance. Therefore, present aimed provide novel perspectives role cisplatin (DDP) resistance NSCLC. A Cell Counting Kit-8 assay was used determine viability cells overexpressed with...
Deubiquitinating enzymes (DUBs) play an important role in ubiquitin-dependent processes as negative regulators of protein ubiquitination. Ubiquitin-specific protease 26 (USP26) is a member this family. The expression Usp26 mammalian testis and other tissues has yet to be fully elucidated. To study the mRNA various murine tissues, reverse transcription (RT)-PCR immunohistochemistry analyses were carried out. RT-PCR analysis showed that transcript was expressed all tested tissues. USP26...
Objective: Formaldehyde (FA) is known to induce lung injury, but the underlying molecular mechanism remains largely unclear. CDR1as an important member of circular RNAs (circRNAs) family and functions as miRNA sponges with gene-regulatory potential. Our earlier circRNA microarray data showed was highly expressed in tissue exposed FA. However, circRNA-CDR1as mediates FA-exposed injury still This study aimed explore role injury. Materials methods: In this study, FA inhaled at doses 0.5, 2.46,...