A5101913024- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer-related gene regulation
- Animal Nutrition and Physiology
- Gut microbiota and health
- Genetic Mapping and Diversity in Plants and Animals
- Mycotoxins in Agriculture and Food
- Plant Pathogens and Resistance
- Hippo pathway signaling and YAP/TAZ
- Digestive system and related health
- Plant Diversity and Evolution
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Genetic diversity and population structure
- Trace Elements in Health
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Botanical Research and Applications
China Agricultural University
2020-2025
State Key Laboratory of Animal Nutrition
2020-2025
Zhongshan Hospital
2021-2025
Fudan University
2021-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Affiliated Hospital of North Sichuan Medical College
2025
Shanghai Institute of Hematology
2025
University of Arizona
2022-2024
Xi'an Jiaotong University
2018-2024
Age-related gastrointestinal decline contributes to whole-organism frailty and mortality. Genistein is known have beneficial effects on age-related diseases, but its precise role in homeostasis of the aging gut remains be elucidated. Here, wild-type mice Zmpste24-/- progeroid were used investigate genistein lifespan mammals. A series longitudinal, clinically relevant measurements performed evaluate effect healthspan. It was found that dietary promoted a healthier longer life associated with...
As an active ingredient of leguminous plants, genistein is extremely important for alleviating various human diseases. However, the regulatory effect on intestinal microbiota in enteritis still unclear. In this study, dextran sodium sulfate (DSS)-induced colitis and potential microbial metabolic regulation mechanism were explored. First, DSS-induced was studied mice. Then antibiotics used to inhibit bacteria verify that microorganisms play role genistein. Finally, mice administrated with...
The epithelial-mesenchymal transition (EMT) is crucial for cancer progression. Evidence has shown that miR-22 and miR-214 play a key role in colon progression; however, the underlying mechanism remains to be known. effects of on EMT are contradictory different cancers, whether involved process needs elucidated. In this study, we evaluated exact regulation cancer. After transfection with expression vector, cell proliferation migration capacity HCT116 RKO cells were significantly suppressed....
miR-497-5p can inhibit cervical cancer cell proliferation. However, the underlying mechanism remains to be elucidated.Bioinformatics was used analyze target genes of miR-497-5p. qRT-PCR and Western blot were mRNA protein expression, respectively. Dual-luciferase reporter assay direct binding between 3'-untranslated region CBX4. Cell viability measured with MTT assay. Flow cytometry performed detect cycle distribution.Here, using bioinformatics methods we firstly found that regulated...
The aim of the present study was to elucidate evolutionary trajectory colon cells from normal mucosa, adenoma, then carcinoma in same microenvironment. Normal colon, adenoma and tissues patient were analyzed by single-cell sequencing, which perfectly simulated process time-dependent cancer due A total 22 cell types identified. Results suggest presence dominant clones including C2 goblet cell, epithelial subtype 1 (Epi1), enterocyte subset 0 (Entero0), Entero5 carcinoma. Epi1 Entero0...
The objectives of this study were to investigate the effectiveness dietary zinc, copper, and manganese hydroxychloride (HC) supplementation on performance, minerals deposition, serum parameters, eggshell ultrastructure, uterus histological structure, inflammatory cytokines in aged hens. A total 560 Hyline Brown layers at 62 wk age randomly allotted into 3 groups (CON, basal diet without extra supplemented; Sulphate HC, with sulphate or levels 80, 15, 80 mg/kg, respectively). trial lasted for...
Gastrointestinal (GI) cancers constitute the largest portion of all human cancers, and most prevalent GI in China are colorectal cancer (CRC), gastric (GC), hepatocellular carcinoma (HCC). Exosomes nanosized vesicles containing proteins, lipids, glycans, nucleic acid, which play important roles tumor microenvironment progression. Aberrant glycosylation is closely associated with cancers; however, little known about glycopattern exosomes from cells. In this study, glycopatterns HCC, CRC, GC...
<title>Abstract</title> <bold>Background: </bold>Intestinal inflammation is an energy-consuming process that may alter energy supply and demand in poultry. During inflammation, the intestinal metabolic profile patterns of partitioning remain unclear. This study investigated effects on intake, heat production (HP), retained (RE) metabolites layer pullets. <bold>Methods: </bold>After 7 d dietary adaption, thirty-two “Jing Tint 6” pullets with average body weight (1,123.50 g ± 8.55) were...
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with poor early detection rates owing to the limited sensitivity and specificity of current biomarker CA19-9. Gut microbiota dysbiosis plays key role in PDAC pathogenesis. This study aimed evaluate noninvasive approach we developed, combining metagenome-derived microbial signatures CA19-9, improve detection. Methods: included 50 treatment-naïve patients their matched controls. Fecal samples were...
The aim of this study was to explore and evaluate the clinical effect phenobarbital combined with ursodeoxycholic acid in treatment neonatal cholestasis. 100 infants were divided into two groups using random number method, 50 cases each group. PB group given routine phenobarbital, combination received same as additionally acid. Observe liver function indicators (γ-glutaminyl transferase (γ-GGT), aspartate (AST), alanine aminotransferase (ALT)), serum bilirubin (the total (TBIL), direct...
Abstract Background Intestinal inflammation is an energy-consuming process that may alter energy supply and demand in poultry. During inflammation, the intestinal metabolic profile patterns of partitioning remain unclear. This study investigated effects on intake, heat production (HP), retained (RE) metabolites layer pullets. Methods After 7 d dietary adaption, 32 “Jing Tint 6” pullets with average body weight (1,123.50 ± 8.55 g) were selected from 96 birds, randomly assigned to two groups...
Abstract The renewal and repair of intestinal epithelium depend on the self-renewal stem cells (ISCs) under physiological pathological conditions. Although previous work has established that exogenous nutrients regulate adult cell activity, little is known about regulatory effect L-arginine ISCs. In this study we utilize mice small (SI) organoid models to clarify role epithelial differentiation We show increases expansion ISCs in mice. Furthermore, CD90 + stromal augment stem-cell function...
Introduction Dietary nutrient content is crucial for energy metabolism and development of gut microbiota. Herein, this study aimed to explore the effects fat-to-fiber ratios on transporter, microbiota when ingredients composition was altered. Methods A total 240 as-hatched broiler chickens were randomly assigned into three groups including low fat-high dietary fiber (LF-HD), medium fat-medium (MF-MD) high fat-low (HF-LD), with diets being iso-protein, broilers offered same commercial from 21...
Environmental perception is a key technology for Advanced Driver Assistance Systems (ADAS) and Autonomous Vehicles, thus crucial prerequisite traffic situation assessment reasonable decision making. Sensor fusion can make full use of the characteristics multi-sensors to achieve complementary advantages improve target recognition precision in various weather conditions. In this paper, robust detection algorithm based on millimeter wave (MMW) radar camera proposed. Firstly, images captured by...
ABSTRACTRing finger protein 6 (RNF6) is a member of the E3 ubiquitin ligase family. Previous studies have reported involvement RNF6 as in progression gastric cancer (GC). However, this study found that has clear localization nucleus GC, indicating role other than ligase. Further chromatin immunoprecipitation sequencing (ChIP-seq) analysis revealed DNA binding and transcriptional regulatory effects involved important pathways such tumor cell cycle apoptosis. Cyclin A1 (CCNA1) CREB (CREBBP)...
Abstract Myogenic differentiation 1 (MyoD1) is a transcription factor that promotes expression of muscle-specific genes. MyoD1 expressed at significantly lower levels in gastric cancer (GC) tissues and cells, it induces apoptosis GC cells. However, functions for cell migration gene have not been documented. We show knockdown promoted invasion whereas overexpression suppressed invasion. performed chromatin immunoprecipitation (ChIP)-sequencing to identify target genes MKN-45 The 2-kb upstream...
Salmonella is the main food-borne pathogen, which can infect intestinal epithelial cells and causes colitis. Genistein has a variety of biological activities that alleviates colitis induced by sodium dextran sulfate in ways, but its protective effects on caused pathogenic bacteria are still unknown.
miR-491 functions as a tumor suppressor in several types of cancer. However, its function and mechanism gastric cancer proliferation metastasis have not been well defined. The aim this study was to explore the role regulatory cell migration cancer.Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) used detect expression pattern tissues. overexpression vector, inhibitor, siHMGA2 were used; MTT, wound healing, transwell assays employed examine for BGC-823 cells. A...