A5019700923- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Synthesis of Indole Derivatives
- Quinazolinone synthesis and applications
- Asymmetric Hydrogenation and Catalysis
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Click Chemistry and Applications
- Catalytic Cross-Coupling Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis and Catalytic Reactions
- Synthesis and Biological Activity
- Fluorine in Organic Chemistry
- Synthesis and Biological Evaluation
- Axial and Atropisomeric Chirality Synthesis
- Vanadium and Halogenation Chemistry
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Nanomaterials for catalytic reactions
Taizhou University
2021-2025
Centre of Advanced Studies
2025
Instituto de Estudos Avançados da Universidade de São Paulo
2025
Wenzhou University
2019
Shenzhen University
2019
University of Freiburg
2017
Chinese Academy of Sciences
2010-2015
Shanghai Institute of Organic Chemistry
2009-2015
East China Normal University
2009-2013
Abstract Oxidation of alcohols is a fundamental transformation related to our daily life. Traditional approaches with at least one stoichiometric amount oxidants are expensive and cause serious environmental burdens. There many reports on the aerobic oxidation simple such as alkyl or phenyl carbinols allylic alcohols, which used oxygen air environmentally benign oxidant forming water only by‐product. However, no protocol has been reported for allenols propargylic alcohols. Thus, it still...
We have developed a modified method for the synthesis of terminal allenes from 1-alkyne: The reaction 1-alkynes with 1.8 equiv Cy(2)NH and 2.5 paraformaldehyde mediated by CuI (0.5 equiv) in refluxing dioxane may produce much higher yields than previously reported protocol many functional groups such as mesylate, hydroxyl group, ether, amide, etc. be tolerated.
ZnI2 has been identified as the catalyst for one-step synthesis of allenes from terminal alkynes and aldehydes with morpholine base in toluene. The reaction is believed to proceed via intermediacy propargylic amines, which was converted by a sequential hydride transfer β-elimination process. applicable both aromatic aliphatic aldehydes. Functionalities such halide, hydroxyl, or amine may be tolerated.
Abstract Tetrahydroisoquinoline alkaloids with a C1 stereogenic center are common unit in many natural and non‐natural compounds of biological importance. Herein we describe novel Cu I ‐catalyzed highly chemo‐ enantioselective synthesis chiral tetrahydroisoquinoline‐alkaloid derivatives from readily available unsubstituted tetrahydroisoquinolines, aldehydes, terminal alkynes the presence ligand ( R , )‐N‐pinap. This synthetic operation installs two substituents 1‐ 2‐positions.
CuBr and ZnI2 have been developed as catalysts or subcatalysts for the efficient asymmetric synthesis of axially chiral allenols with up to 97% ee from readily available propargylic alcohols, aliphatic aromatic aldehyde, pyrrolidine, commerically ligands. The alcohol unit in terminal alkynes plays a very important role ensuring high enantioselectivity via coordination.
Herein, a Cu(II)-catalyzed facile construction of synthetically valuable spiro compounds from β-naphthols in air is reported, which N,N-dimethylaminoethanol (DMEA) serves as an efficient and unique C1 synthon. This transformation proceeds through ortho-quinone methide (o-QM) formation/Michael addition/dearomatization sequence, affording various spiro(naphthalenenaphtho)furan-2-ones moderate to excellent yields.
Cu( ii )-catalyzed divergent synthesis of naphthofurans and benzochromanes through [3 + 2 1] 1 annulations is established.
A selective and efficient synthesis of diaryl 1,3,5-oxadiazines was established for the first time from simple readily available amidines in wet DMSO. DMSO employed as a dual carbon synthon water offered oxygen atom to construct oxadiazine ring. The reaction involved two new C–N C–O bond formations.
Abstract An efficient one‐step synthesis of functionalized allenes from readily available terminal alkynes and aldehydes by applying the effect a dialkylamine has been developed. The protocol is catalyzed copper(I) iodide believed to play very important role in transformation.
A transition metal-free method for de novo construction of diverse sulfonated pyrazoles from readily available sulfonyl hydrazides, 1,3-diketones, and sodium sulfinates was established under mild conditions. Pyrazoles bearing two different groups were obtained in one step. The features a diversity substituents the pyrazole products remarkably simple work-up.
A highly efficient CuBr-catalyzed coupling of ketones, amines and alkynes (KA2) forming propargylic bearing a quaternary carbon center with the broadest scope so far has been developed.
Abstract Tetrahydroisoquinoline alkaloids with a C1 stereogenic center are common unit in many natural and non‐natural compounds of biological importance. Herein we describe novel Cu I ‐catalyzed highly chemo‐ enantioselective synthesis chiral tetrahydroisoquinoline‐alkaloid derivatives from readily available unsubstituted tetrahydroisoquinolines, aldehydes, terminal alkynes the presence ligand ( R , )‐N‐pinap. This synthetic operation installs two substituents 1‐ 2‐positions.
Rhodium-catalyzed regioselective addition of azlactones to internal alkynes combined with aza-Cope rearrangement provides efficient atom economic access 2-allyl-3-oxazolin-5-one derivatives. Extension a triple domino process, in which the above process is situ azlactone formation starting from amino acids renders this even more attractive. Subsequent thermolysis 2-allyl-3-oxazolines enabled de novo synthesis trisubstituted pyridines.
Transition-metal-free synthesis of diversely substituted 4-sulfenyl-5-aminopyrazoles was developed under mild conditions through NaI-mediated three-component reaction β-ketonitriles, disulfides, and hydrazines. The pyrazole products were constructed via consecutive cleavage C-O S-S bonds recombination C-N C-S bonds. methodology features broad substrate scope, transition-metal-free conditions, easy manipulation.
An efficient copper-mediated three-component reaction of one molecule amine and two molecules nitriles affording fully substituted 1,2,4-triazoles has been developed. A tandem double addition–oxidative cyclization mechanism proposed for the synthesis 1,2,4-triazoles.
The synthesis of N-heterocycles composes a significant part synthetic chemistry. In this report, Cu(II)-catalyzed green and efficient pyrrolo[1,2-a]quinoxaline, quinazolin-4-one, benzo[4,5]imidazoquinazoline derivatives was developed, employing N,N-dimethylethanolamine (DMEA) as C1 synthon. Green oxidant O2 is critical in these transformations, facilitating the formation key intermediate─a reactive iminium ion. method conducted under mild conditions compatible with diversity functional...
Zinc diiodide has been identified as an effective reagent for the efficient synthesis of trisubstituted allenes from propargylic amines.
Reactions with diverse C1 synthons to realize homologation were well explored. However, homologations occurring twice one synthon in a reaction less reported. We disclose herein Cu(II)-catalyzed novel and efficient synthesis of 2H-chromenes from 2-naphthols, 1,3-diketones, N,N-dimethylethanolamine (DMEA) as dual carbon synthon. Various different functional groups are constructed moderate good yields. This is the first report that DMEA acts
Abstract Rhodium‐catalyzed regioselective addition of azlactones to internal alkynes combined with aza‐Cope rearrangement provides efficient atom economic access 2‐allyl‐3‐oxazolin‐5‐one derivatives. Extension a triple domino process, in which the above process is situ azlactone formation starting from amino acids renders this even more attractive. Subsequent thermolysis 2‐allyl‐3‐oxazolines enabled de novo synthesis trisubstituted pyridines.
A regioselective hydration of ynones was developed <italic>via</italic> gold catalysis, providing a simple, mild, and efficient method for the synthesis variety 1,3-diketone derivatives.
A one-pot debromination/sulfonylation strategy was developed for the direct transformation of α,α-dibromoketones into β-ketosulfones in presence sulfinate salts a methanol solution.
We report an efficient iron-catalyzed cross-dehydrogenative coupling [4 + 2] annulation of secondary/tertiary anilines with quinazolinones to generate quinoline–spiroquinzolinones. The reaction proceeds smoothly a relatively broad variety functional groups, cheap transition metal catalyst (FeCl3), and environmentally friendly oxidant (H2O2/O2) under mild conditions. Creatively, N-methylanilines are employed for the first time cycloaddition as both methyl methylene sources attached N atom...
We have demonstrated a very general method for the preparation of essentially any terminal 2,3-allenol from corresponding alkynols, which may be easily available propargylic alcohols by alkylation, or alkynes deprotonation and 1,2-addition with aldehydes ketones, subsequent base-catalyzed triple-bond migration.
A simple, mild, and efficient catalytic aminothiolation of terminal alkynes for the synthesis both 2- 3-substituted thiazolo[3,2-<italic>a</italic>]benzimidazoles is established upon catalysis with copper(<sc>i</sc>), in which complementary regioselectivities could be achieved by using sterically different phenanthroline-based ligands.
A green and facile synthesis of previously unreported C,N -disulfonated 5-amino pyrazoles was established through an iodine-catalyzed cascade reaction.