A5084427779- Mycotoxins in Agriculture and Food
- Pesticide Residue Analysis and Safety
- Bone Metabolism and Diseases
- Insect and Pesticide Research
- Plant Toxicity and Pharmacological Properties
- Estrogen and related hormone effects
- Surgical Sutures and Adhesives
- Advanced biosensing and bioanalysis techniques
- Advanced Chemical Sensor Technologies
- Tea Polyphenols and Effects
- Pharmacological Effects of Natural Compounds
- Ginger and Zingiberaceae research
- Analytical Chemistry and Chromatography
- Bacterial biofilms and quorum sensing
- Microbial Metabolism and Applications
- Pancreatic function and diabetes
- Sleep and Wakefulness Research
- Wheat and Barley Genetics and Pathology
- Animal Nutrition and Physiology
- Meat and Animal Product Quality
- Regulation of Appetite and Obesity
- Wound Healing and Treatments
- Mast cells and histamine
- Surgical site infection prevention
- Pharmacological Effects and Toxicity Studies
Southern Medical University
2024
Nanjing Agricultural University
2009-2023
Guangdong Medical College
2002-2022
Yeungnam University
2017-2019
Guangdong Pharmaceutical University
2017-2018
Lung Institute
2018
Prince of Wales Hospital
2005
Abstract Green tea, a water extract of non-fermented leaves Camellia sinensis L., is one the nonalcoholic beverages in China. It becoming increasingly popular worldwide, because its refreshing, mild stimulant and medicinal properties. Here we examined quorum sensing inhibitory potentials tea polyphenols (TP) as antivirulence compounds both vitro vivo . Biosensor assay data suggested minimum concentrations (MICs) TP against selected pathogens were 6.25 ~ 12.5 mg/mL. At sub-MIC, can...
ABSTRACT T‐2 toxin is now considered to be related bone malformation such as incomplete ossification, absence of bones and fused bones. In this study, primary cultures chicken tibial growth plate chondrocytes (GPCs) were treated with various concentrations (5, 50, 500 n m ) in the presence N ‐acetyl‐cysteine (NAC) investigate effects antioxidant NAC on toxin‐induced toxicity. Our results showed that markedly decreased cell viability, alkaline phosphatase activity glutathione content ( P <...
Abstract Sirt1, a key regulator of metabolism and longevity, has recently been implicated in the regulation allergic reactions, although underlying mechanism remains unclear. Here we show that Sirt1 negatively regulates FcεRI-stimulated mast cell activation anaphylaxis through two mutually regulated pathways involving AMP-activated protein kinase (AMPK) tyrosine phosphatase 1B (PTP1B). Mast cell-specific knockout dampened AMPK-dependent suppression FcεRI signaling, thereby augmenting both...
As a master regulator for metabolic and energy homeostasis, AMPK controls the activity of enzymes transcription factors in response to cellular ATP status. has been thus recognized as main target regulation metabolism. Here, we report that can be down-regulated by cullin-RING ubiquitin E3 ligase 4A (CRL4A) with cereblon (CRBN). CRL4A interacted holoenzymes mediated AMPKα-specific polyubiquitination its proteasomal degradation through non-K48 polyubiquitin linkages. In ubiquitination system,...
In this study, we evaluated the effects of herb medicine formula Gushukang (GSK) on bone characteristics and osteoporosis in end-of-lay hens. One thousand 55-wk-old ISA caged layers were allotted randomly to 2 groups. The control group was given basal diet, GSK diet supplemented with additional (1 g/kg) for 10 wk. Egg production, shell quality, radiographic density, biochemical markers turnover determined. results showed that significantly increased egg laying rate decreased percentage...
This study was performed to investigate the effect of letrozole, an aromatase inhibitor, on osteogenesis medullary bone in prelay pullets. Three hundred fifteen 95-d-old ISA pullets were used. After 10 d adaptation cages, 15 selected randomly collect serum and samples rest assigned 2 groups with 3 replicates each. One group control other letrozole-treated, fed 0.5 mg letrozole per pullet day for 18 d. The from these birds collected during experiment. Estradiol testosterone assayed using...
Alpinia officinarum Hance (AOH) is a traditional herbal medicine specific to south China and serves as civil medication application of an antioxidant. Growing evidence demonstrates that antioxidants are beneficial for the treatment osteoporosis. This study was designed investigate antiosteoporotic effects total extracts from AOH in ovariectomised (OVX) rats different fractions on primary osteoblasts activities. The extract extracted by refluxing using 95% ethanol, then five (F1–F5) were...
Vascular endothelial growth factor (VEGF) is an essential mediator of angiogenesis and endochondral ossification. To explore the role VEGF in avian diseases such as tibial dyschondroplasia (TD), a typical disorder ossification, we expressed identified recombinant chicken (chVEGF) protein Pichia pastoris evaluated its effects on thiram-induced TD broiler chickens. The SDS-PAGE showed that 2 proteins, with molecular weights ~46 ~70 kDa, were obtained. Western blot analysis indicated proteins...
In this study, we demonstrated that Ent‐11α‐hydroxy‐15‐oxo‐kaur‐16‐en‐19‐oic‐acid (5F) had stronger cytotoxicity against MKN‐45, a gastric cancer cell line bearing wild‐type p53 than MKN‐28, another containing missense mutation in p53. The rapid increase of ROS level was involved the mechanism cytotoxicity. Classical features apoptosis induced by 5F were observed MKN‐45 cells only or more significant MKN‐28 cells. Translocation Bax from cytosol to mitochondria, reduction Δ ψ m and DNA...
Ca2+ plays a major role in the regulation of signal transduction. Transient receptor potential vanilloid 6 is Ca2+-selective channel that serves as an important rate-limiting step facilitation entry into cells, but little known about transient chickens. In this study, we evaluated effects gene interference on expression calbindin-D28K, Na+/Ca2+ exchangers, and plasma membrane ATPase 1b to investigate mechanism underlying 6. Three hairpin siRNA vectors targeting (pSIREN- 6) negative control...