A5025266463- Liver Disease and Transplantation
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
- Renal Transplantation Outcomes and Treatments
- Cardiac Fibrosis and Remodeling
- Nutrition and Health in Aging
- Frailty in Older Adults
- Public Health Policies and Education
- Organ Donation and Transplantation
- Mechanical Circulatory Support Devices
- Acute Myeloid Leukemia Research
- Injury Epidemiology and Prevention
- COVID-19 and healthcare impacts
- Angiogenesis and VEGF in Cancer
- Child Abuse and Trauma
- Biomedical Ethics and Regulation
- Hepatitis C virus research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Innovations in Medical Education
- Pharmacy and Medical Practices
- Global Health Care Issues
University of Miami
2013-2025
Claremont Graduate University
2023-2024
Stem Cell Institute
2013-2017
Emmes (United States)
2017
Miami Transplant Institute
2014
Whether culture-expanded mesenchymal stem cells or whole bone marrow mononuclear are safe and effective in chronic ischemic cardiomyopathy is controversial.To demonstrate the safety of transendocardial cell injection with autologous (MSCs) (BMCs) patients cardiomyopathy.A phase 1 2 randomized, blinded, placebo-controlled study involving 65 left ventricular (LV) ejection fraction less than 50% (September 1, 2009-July 12, 2013). The compared MSCs (n=19) placebo (n = 11) BMCs 19) 10), year...
Although human mesenchymal stem cells (hMSCs) have been tested in ischemic cardiomyopathy, few studies exist chronic nonischemic dilated cardiomyopathy (NIDCM).The authors conducted a randomized comparison of safety and efficacy autologous (auto) versus allogeneic (allo) bone marrow-derived hMSCs NIDCM.Thirty-seven patients were to either allo- or auto-hMSCs 1:1 ratio. Patients recruited between December 2011 July 2015 at the University Miami Hospital. received (100 million) by...
Rationale: Cell dose and concentration play crucial roles in phenotypic responses to cell-based therapy for heart failure. Objective: To compare the safety efficacy of 2 doses allogeneic bone marrow–derived human mesenchymal stem cells identically delivered patients with ischemic cardiomyopathy. Methods Results: Thirty cardiomyopathy received a blinded manner either 20 million (n=15) or 100 via transendocardial injection (0.5 cc per × 10 injections patient). Patients were followed 12 months...
Aging frailty, characterized by decreased physical and immunological functioning, is associated with stem cell depletion. Human allogeneic mesenchymal cells (allo-hMSCs) exert immunomodulatory effects promote tissue repair. This a randomized, double-blinded, dose-finding study of intravenous allo-hMSCs (100 or 200-million [M]) vs placebo delivered to patients (n = 30, mean age 75.5 ± 7.3) frailty. The primary endpoint was incidence treatment-emergent serious adverse events (TE-SAEs) at...
Impaired endogenous stem cell repair capacity is hypothesized to be a biologic basis of frailty. Therapies that restore regenerative may therefore beneficial. This Phase 1 study evaluated the safety and potential efficacy intravenous, allogeneic, human mesenchymal (allo-hMSC)-based therapy in patients with aging In this nonrandomized, dose-escalation study, received single intravenous infusion allo-hMSCs: 20-million (n = 5), 100-million or 200-million cells 5). The primary endpoint was...
Background & Aims: In the US, and much of world, prioritization for a deceased donor liver transplant focuses on sickest-first based allocating organs using MELD score. There have been calls to instead allocate survival benefit, but impact such system broader waitlist population is unknown. Approach Results: We performed simulation study Liver Simulated Allocation Model (LSAM) compare current US allocation one, different time horizons, focused on: pre-transplant only, post-transplant...
Patients are prioritized for liver transplantation (LT) under an “urgency‐based” system using the Model End‐Stage Liver Disease score. This focuses solely on waitlist mortality, without considerations of posttransplant morbidity, and health care use. We sought to develop internally validate a continuous risk score during 5‐year 10‐year time horizons. retrospective cohort study used national registry data adult deceased donor LT (DDLT) recipients with ≥90 days pretransplant waiting from...
Transplantation of kidneys from hepatitis C virus (HCV)-viremic donors into HCV-negative patients followed by direct-acting antiviral therapy was an important breakthrough to increase the number life-saving kidney transplants. Data suggest that these transplants offer several benefits; however, it is unknown whether adoption this practice has been shared equitably, especially among disadvantaged groups.We evaluated United Network for Organ Sharing data on HCV-seronegative adult...
Cirrhosis is a major cause of death and associated with extensive health care use. Patients cirrhosis have complex treatment choices due to risks morbidity mortality. To optimally counsel treat patients requires tools predict their longer-term liver-related survival. We sought develop validate risk score survival cirrhosis.We conducted retrospective cohort study adults no life-limiting comorbidities. Adults within the Veterans Health Administration were used for model training internal...
Recently proposed rulemaking from Centers for Medicare and Medicaid Services would change how organ procurement organizations (OPOs) are evaluated. The proposals include using national inpatient death data to define a standardized denominator calculate comparable donation rates among OPOs. Based on these objective metrics, OPOs not performing at prespecified threshold will be required rapidly improve performance avoid decertification. We sought determine whether rapid OPO improvement was...
Cardiac retransplantation is the standard treatment for patients with advanced graft vasculopathy. It remains controversial due to scarcity of donors and poor results when compared novo transplant.
This study explored the current and desired identity of DrPH degree, focusing on whether competencies set by Council Education for Public Health (CEPH) adequately prepare graduates effective public health practice. Additionally, investigated necessity standardization in training, referring to a consensus-driven approach that equips future practitioners with practical skillsets applicable real-world scenarios.A national cross-sectional online survey titled "National leaders & needs...
Background: Heart failure with reduced ejection fraction (HFrEF) is associated increased mortality, morbidity, and readmission rates. Evidence-based practice outlines that HFrEF patients should be on guideline-directed medical therapy (GDMT), including medication from four categories: renin-angiotensin system inhibitors, β-blockers approved for the treatment of heart failure, aldosterone antagonists, sodium-glucose cotransporter 2 inhibitors. Nurse-led patient advocacy to discharged GDMT can...
Abstract Background The Doctor of Public Health (DrPH) is the highest attainable degree in field public health, specifically designed to prepare professionals address complex health challenges practical settings. This study was explore importance achieving a shared and uniform understanding DrPH education, assess optimal direction for training, investigate specific curriculum requirements by gathering insights from current students alumni United States. Methods A total 13 focus group...