Tom Defoirdt

ORCID: 0000-0002-7446-2246
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About
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Research Areas
  • Aquaculture disease management and microbiota
  • Vibrio bacteria research studies
  • Bacterial biofilms and quorum sensing
  • Aquaculture Nutrition and Growth
  • Invertebrate Immune Response Mechanisms
  • Microplastics and Plastic Pollution
  • Microbial Community Ecology and Physiology
  • Marine Bivalve and Aquaculture Studies
  • Antimicrobial Peptides and Activities
  • Bacteriophages and microbial interactions
  • Identification and Quantification in Food
  • Aquatic Invertebrate Ecology and Behavior
  • Pharmaceutical and Antibiotic Environmental Impacts
  • biodegradable polymer synthesis and properties
  • Water Treatment and Disinfection
  • Gut microbiota and health
  • Bacterial Genetics and Biotechnology
  • Mosquito-borne diseases and control
  • Fecal contamination and water quality
  • Bacillus and Francisella bacterial research
  • Water Quality Monitoring Technologies
  • Wastewater Treatment and Nitrogen Removal
  • Mollusks and Parasites Studies
  • Antibiotic Resistance in Bacteria
  • Spacecraft and Cryogenic Technologies

Ghent University
2016-2025

Ghent University Hospital
2012-2025

Aquatic Systems (United States)
2024

Udayana University
2024

Ecologie Microbienne Lyon
2013-2020

Aligarh Muslim University
2016

Abstract Background To date, only few compounds targeting the AI-2 based quorum sensing (QS) system are known. In present study, we screened cinnamaldehyde and substituted cinnamaldehydes for their ability to interfere with QS. The mechanism of QS inhibition was elucidated by measuring effect on bioluminescence in several Vibrio harveyi mutants. We also studied vitro these biofilm formation, stress response virulence spp. were evaluated an vivo assay reduction towards Artemia shrimp. Results...

10.1186/1471-2180-8-149 article EN cc-by BMC Microbiology 2008-09-16

Abstract Knowledge on the importance of associations between bacteria and microalgae in aquatic ecosystems is rather limited at moment, mostly due to a lack studies molecular biochemical level microorganisms. This paper discusses current knowledge microalgae–bacteria interactions their potential impacts productivity, efficiency sustainability aquaculture. Current findings suggest that are complex specific. The release stimulatory products by enhance growth microalgae, vice versa, indicates...

10.1111/raq.12024 article EN Reviews in Aquaculture 2013-05-14

Summary The human‐specific HF183 Bacteriodes 16S rRNA genetic marker can be used to detect human faecal pollution in water environments. However, there is currently no method quantify the prevalence of this environmental samples. We developed a real‐time polymerase chain reaction (PCR) assay using SYBR Green I detection and To decrease amplicon length suitable size for PCR detection, new reverse primer was designed validated on animal use newly combination with did not specificity but...

10.1111/j.1462-2920.2004.00702.x article EN Environmental Microbiology 2004-11-19

Traditional treatment of bacterial infections relies heavily on the use antibacterial compounds that either kill bacteria (bactericidal) or inhibit their growth (bacteriostatic). Typically, targets for main conventional antibiotics are essential cellular processes such as cell wall biosynthesis, protein synthesis, and DNA replication repair. However, resistance to these drugs arises spreads very rapidly, even an extent have been identified simultaneously resistant all available [1]. The...

10.1371/journal.ppat.1000989 article EN cc-by PLoS Pathogens 2010-07-08

Summary This study aimed at getting a deeper insight in the molecular mechanism by which natural furanone ( 5Z )‐4‐bromo‐5‐(bromomethylene)‐3‐butyl‐2( 5H )‐furanone disrupts quorum sensing Vibrio harveyi . Bioluminescence experiments with signal molecule receptor double mutants revealed that blocks all three channels of V. system. In further using mutations transduction pathway, compound was found to block sensing‐regulated bioluminescence interacting component located downstream Hfq...

10.1111/j.1462-2920.2007.01367.x article EN Environmental Microbiology 2007-06-26

Autoinducer 2 (AI-2) quorum sensing was shown before to regulate the virulence of Vibrio harveyi towards brine shrimp Artemia franciscana. In this study, several different pathogenic V. harveyi, campbellii, and parahaemolyticus isolates were produce AI-2. Furthermore, disruption AI-2 by a natural synthetic brominated furanone protected gnotobiotic from in vivo challenge tests.

10.1128/aem.00753-06 article EN cc-by Applied and Environmental Microbiology 2006-09-01

Abstract For most marine aquaculture species, one of the main bottlenecks is stable production high quality juveniles. The and unpredictable mortality in first weeks after hatching fish larvae remains a challenging problem that needs to be solved. severity differs between but cannot considered adequately solved for any species. Both scientific evidence experience hatcheries variety fish, shrimp shellfish species are accumulating as support hypothesis detrimental fish–microbe interactions...

10.1111/j.1753-5131.2012.01082.x article EN other-oa Reviews in Aquaculture 2013-05-01

Summary Infections caused by antibiotic‐resistant luminescent Vibrio s can cause dramatic losses in aquaculture. In this study, the short‐chain fatty acid β‐hydroxybutyrate and its polymer poly‐β‐hydroxybutyrate were investigated as possible new biocontrol agents. β‐Hydroxybutyrate was shown to completely inhibit growth of pathogenic campbelli at 100 mM. Moreover, addition mM culture water Artemia nauplii infected with V. strain significantly increased survival nauplii. As is a non‐selective...

10.1111/j.1462-2920.2006.01161.x article EN Environmental Microbiology 2006-10-25

To study the potential biocontrol activity of bioflocs technology.Glycerol-grown were investigated for their antimicrobial and antipathogenic properties against opportunistic pathogen Vibrio harveyi. The did not produce growth-inhibitory substances. However, biofloc supernatants decreased quorum sensing-regulated bioluminescence V. This suggested that had this because sensing regulates virulence vibrios towards different hosts. Interestingly, addition live significantly increased survival...

10.1111/j.1365-2672.2010.04791.x article EN Journal of Applied Microbiology 2010-06-09

Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence human infections followed regional climatic trends outbreaks occurring during episodes unusually warm weather. Similar patterns were also observed affecting organisms such as fish, bivalves corals. Basic knowledge is still lacking the ecology evolutionary biology these bacteria well their virulence mechanisms. Current...

10.3389/fmicb.2015.00830 article EN cc-by Frontiers in Microbiology 2015-08-13

Abstract The Harveyi clade or core group of the Vibrio genus includes both pathogenic and non‐pathogenic bacteria. Some species belonging to clade, such as harveyi , alginolyticus campbellii parahaemolyticus include serious pathogens aquatic organisms. Importantly, within these species, some strains are pathogenic, whereas others not. Other members natriegens mytili reported be non‐pathogenic. As bacteria show a high diversity with respect virulence virulent cause mortalities in aquaculture...

10.1111/j.1753-5131.2012.01061.x article EN Reviews in Aquaculture 2012-06-01

Vibrios belonging to the Harveyi clade are among major pathogens of aquatic organisms. Quorum sensing (QS) is essential for virulence V. harveyi towards different hosts. However, most factors reported be controlled by QS date negatively regulated QS, therefore suggesting that their impact on limited. In this study, we report positively regulates flagellar motility. We found autoinducer synthase mutants showed significantly lower swimming motility than wild type, and could restored adding...

10.1111/1462-2920.12420 article EN Environmental Microbiology 2014-02-17
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