A5043013944- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Air Quality and Health Impacts
- Cardiovascular and exercise physiology
- Respiratory and Cough-Related Research
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Inhalation and Respiratory Drug Delivery
- Occupational exposure and asthma
- Heart Rate Variability and Autonomic Control
- Neonatal Respiratory Health Research
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nitric Oxide and Endothelin Effects
- Indoor Air Quality and Microbial Exposure
- Allergic Rhinitis and Sensitization
- Cystic Fibrosis Research Advances
- Air Quality Monitoring and Forecasting
- Noise Effects and Management
- IL-33, ST2, and ILC Pathways
- Sports Performance and Training
- Pulmonary Hypertension Research and Treatments
- Climate Change and Health Impacts
- Receptor Mechanisms and Signaling
Institut Pasteur de Lille
2016-2025
Université de Lille
2015-2025
IMPact de l'Environnement Chimique sur la Santé humaine
2018-2023
Centre Hospitalier Universitaire de Lille
2012-2022
Université Lille Nord de France
2011-2021
Institut de Biologie de Lille
2012-2021
Centre Hospitalier Universitaire d'Angers
2021
Institut Pasteur
2021
Inserm
2000-2020
Center for Infection and Immunity of Lille
2020
To elucidate the pathogenesis of bronchospasm in congestive heart failure, we studied 23 patients with chronic impairment left ventricular function due to coronary artery disease or dilated cardiomyopathy. In 21 them found marked bronchial hyperresponsiveness methacholine. The mean dose (±SD) methacholine that elicited a 20 percent decrease forced expiratory volume one second (FEV1) was 421±298-μg, nearly same as symptomatic asthma. contrast, there no response 9 10 who had but normal...
A genome-wide search was conducted in 107 nuclear families with at least two siblings asthma, as part of the French EGEA study. two-stage analysis strategy applied to divided into independent subsets 46 and 61 families, where all regions detected first set were tested for replication second set. In addition, reported by published genome scans different populations examined total sample. 254 markers typed 70% them Linkage investigated model-free methods asthma four asthma-related phenotypes:...
Abstract The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), reductase (GR), ascorbic acid α-Tocopherol) malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), active (n=16; 21.4±1.9 YA), old 65.1±3.5 OS) (n=17; 67.2±4.8 OA). Antioxidant MDA were assessed at rest after an incremental exercise. There was no...
Air pollution impacts health by increasing mortality and the incidence of acute events in unhealthy individuals. In contrast, effects healthy individuals are less obvious. The present study was designed to evaluate associations between short-term exposure air on one hand lung function, inflammatory markers other middle-aged, non-smoking adults with no respiratory disease, two urban areas northern France.A sample 1506 (aged from 40 65) disease selected participants 2011-2013 cross-sectional...
The purpose of this study was to measure physiological responses during exercise performed until exhaustion at the intensity corresponding maximal lactate steady state (MLSS) in order determine why subjects stopped.Eleven male trained a test MLSS on cycle ergometer exhaustion.Time 55.0 (SD 8.5) min. No variation observed between 10th and last minute for arterial pyruvate, bicarbonate, haemoglobin concentrations, redox state, oxygen pressure, saturation, osmolality, haematocrit, uptake,...
A major challenge of drug delivery using colloids via the airway is to understand mechanism implied in their interactions with epithelial cells. The purpose this work was characterize process endocytosis and exocytosis cationic nanoparticles (NPs) made maltodextrin which were developed as a system for antigens vaccine applications. Confocal microscopy demonstrated that these NP are rapidly endocytosed after little 3 min incubation, also faster than binding since most NPs found middle cells...
Purpose The aim of this study was to evaluate whether oxidative stress markers and biomarkers muscle injury would be affected by aging at rest in response an incremental exhaustive exercise. Methods Fifteen young (20.3±2.8 years) fifteen older adults (65.1±3.5 performed cycle ergometer test exhaustion. Before after exercise, [superoxide dismutase (SOD), glutathione peroxidase (GPX), reductase (GR), ascorbic acid, α-Tocopherol, malondialdehyde (MDA)] [creatine kinase (CK), lactate...
Severe pectus excavatum are common in adult patients, often causing psychological complaints and physiological impairments. Although lung function at rest may minimally deteriorate after surgical correction, it remains unclear if surgery improves exercise capacity. The objective of present study is to assess whether the repair adults would improve tolerance.A prospective was performed compare pulmonary cardiovascular maximal exercise, before, 1 year repair.From December 2005 May 2009, 120...
Systemic sclerosis-related interstitial lung disease (SSc-ILD) is the leading cause of death in SSc. In this study, we aimed to describe baseline severity and evolution forced vital capacity (FVC) diffusing for carbon monoxide (DLCO) patients with SSc-ILD assess clinical, biological high-resolution CT scan (HRCT) predictors evolution. Baseline serial FVC DLCO were collected 75 followed during 6.4±4.2 years (n = 557 individual data). was modelled using a linear mixed model random effect....
To what extent blood granulocyte patterns may predict asthma control remains under-studied. Our aim was to study associations between neutrophilia and eosinophilia outcomes in adults. Analyses were conducted 474 asthmatics from the first follow-up of Epidemiological Study on Genetics Environment Asthma (EGEA2), including 242 who adults a decade earlier (EGEA1). At EGEA2, assessed using Global Initiative for definition (2015), exacerbations by use urgent care or courses oral corticosteroids...
Rationale: Targeted lung denervation (TLD) is a bronchoscopic radiofrequency ablation therapy for chronic obstructive pulmonary disease (COPD), which durably disrupts parasympathetic nerves to decrease airway resistance and mucus hypersecretion.Objectives: To determine the safety impact of TLD on respiratory adverse events.Methods: We conducted multicenter, randomized, sham bronchoscopy-controlled, double-blind trial in patients with symptomatic (modified Medical Research Council dyspnea...
Pulmonary function tests are seldom performed in preschool children with asthma. The aim of this multicenter study was to compare pulmonary 74 asthma (height 90-130 cm) and 84 healthy control subjects. Functional residual capacity (helium dilution technique) expiratory interrupter resistance (interrupter were measured. As compared children, had a significantly higher (0.77 +/- 0.20 vs. 0.92 0.22 kPa. L-1. second, p < 0.001) lower specific conductance (p 0.005) values. Resistance values than...
A new in vivo model is described which anaesthetized pigs were used to study vascular responses the bronchial, upper tracheal and laryngeal circulation upon electrical stimulation of vagal or superior nerves. Vagal nerve increased blood flow bronchial artery artery, respectively. After pre‐treatment with atropine vasodilatory response was not modified while increase reduced. The ganglionic blocking agent chlorisondamine further reduced evoked decrease resistance but did influence artery....
Pulmonary function tests have rarely been assessed in preschool children with cystic fibrosis (CF). The objective of this multicenter study was to compare pulmonary 39 CF (height, 90–130 cm; 16 homozygous ΔF508) and 79 healthy control children. Functional residual capacity (helium dilution technique) expiratory interrupter resistance (Rintexp) (interrupter were measured. As compared children, had significantly higher Rintexp, expressed as absolute values Z-scores (1.05 ± 0.36 versus 0.80...
Blood flow changes upon systemic i. v.injections in the pig of various neuropeptides, capsaicin, bradykinin and histamine were directly monitored by a Transonic blood flowmeter superior laryngeal, bronchial femoral arteries indirectly larynx skin using laser Doppler flowmetry. To minimize influence compensatory reflexes indirect effects, pigs pre‐treated with atropine, guanethidine, chlorisondamine capsaicin. Substance P (SP), vasoactive intestinal polypeptide (VIP), peptide histidine...