A5062901464- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Airway Management and Intubation Techniques
- Respiratory and Cough-Related Research
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Pneumothorax, Barotrauma, Emphysema
- Pediatric health and respiratory diseases
- Delphi Technique in Research
- Transplantation: Methods and Outcomes
- Atomic and Subatomic Physics Research
- Voice and Speech Disorders
- Childhood Cancer Survivors' Quality of Life
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Obstructive Sleep Apnea Research
- Cardiovascular and Diving-Related Complications
- Respiratory viral infections research
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
University of Pittsburgh
2019
European Respiratory Society
2017
Royal Brompton Hospital
2017
University Hospital Heidelberg
2017
Heidelberg University
2017
Pulmonary Associates
2014
Institute for Asthma and Allergy
2012
Bronchoscopic lung-volume reduction with the use of one-way endobronchial valves is a potential treatment for patients severe emphysema. To date, benefits have been modest but hypothesized to be much larger in without interlobar collateral ventilation than those ventilation.We randomly assigned emphysema and confirmed absence bronchoscopic endobronchial-valve (EBV group) or continued standard medical care (control group). Primary outcomes were changes from baseline 6 months forced expiratory...
<h3>Background</h3> The lung volume reduction (LVR) coil is a minimally invasive bronchoscopic nitinol device designed to reduce hyperinflation and improve elastic recoil in severe emphysema. We investigated the feasibility, safety efficacy of LVR treatment prospective multicentre cohort trial patients with <h3>Methods</h3> Patients were treated 11 centres. Safety was evaluated by recording all adverse events, St George9s Respiratory Questionnaire (SGRQ) as primary endpoint, pulmonary...
<b><i>Background:</i></b> Bronchoscopic lung volume reduction using one-way endobronchial valves (EBVs) has been proven to be effective in patients with severe emphysema. However, the selection of without collateral ventilation prior treatment is critical for procedural success. Collateral can assessed directly Chartis system or indirectly computed tomography (CT) fissure analysis. <b><i>Objectives:</i></b> We retrospectively evaluated...
Severe COPD patients can significantly benefit from bronchoscopic lung volume reduction (BLVR) treatments with coils or endobronchial valves. However, the potential impact of BLVR on survival is less understood. Therefore, our aim was to investigate rate in who are evaluated for treatment and whether there a difference between undergo do not.We included visited hospital consultation evaluating their eligibility performed pulmonary function tests during this visit. Furthermore, vital status...
Residual volume (RV) measured by body plethysmography is a routine measurement in clinical pulmonary practice and often an important outcome variable trials. However, it not known what size of improvement can be regarded as being severe emphysema patients. Therefore, the aim study to establish minimal difference (MID) for RV patients undergoing bronchoscopic lung reduction. 91 were included. total capacity (TLC) plethysmography. MID estimates calculated anchor-based distribution-based...
<h3>Background</h3> Parasympathetic pulmonary nerves release acetylcholine that induces smooth muscle constriction. Disruption of parasympathetic improves lung function and COPD symptoms. <h3>Aims</h3> To evaluate 'targeted denervation' (TLD), a novel bronchoscopic therapy based on ablation surrounding the main bronchi, as potential for COPD. <h3>Methods</h3> This 1-year, prospective, multicentre study evaluated TLD in patients with forced expiratory volume 1 s (FEV<sub>1</sub>)/forced vital...
In patients with heterogeneous emphysema, surgical and bronchoscopic lung volume reduction (LVR) treatments are available. However, for homogeneous emphysema these hardly investigated seem less effective. Bronchoscopic LVR coil treatment has been shown to be effective in but this not exclusively emphysema.The aim of study was investigate the safety efficacy emphysema.In single-arm, open-label study, received a maximum 12 coils (PneumRx Inc., Mountain View, Calif., USA) each upper lobe two...
The St George's Respiratory Questionnaire (SGRQ) is a validated, commonly used questionnaire for measuring quality of life in patients with chronic obstructive pulmonary disease (COPD). current established minimal important difference (MID) SGRQ scores an average COPD population −4 units. However, severe COPD, the MID has not been thoroughly validated. We re-determined this patient group. 115 (forced expiratory volume 1 s (FEV ) 26±9% predicted, score 62±11 units; mean± sd ,) who...
Abstract Background and objective Bronchoscopic lung volume reduction coil ( LVR ‐coil) treatment has been shown to be safe clinically effective in patients with severe emphysema the short term; however, long‐term safety effectiveness not evaluated. The aim of this study was investigate ‐coil emphysema. Methods Thirty‐eight (median age is 59 years, forced expiratory 1 s 27% predicted) who were treated clinical trials invited for a voluntary annual visit. Safety evaluated by chest X ‐ray...
Rationale: Targeted lung denervation (TLD) is a bronchoscopic radiofrequency ablation therapy for chronic obstructive pulmonary disease (COPD), which durably disrupts parasympathetic nerves to decrease airway resistance and mucus hypersecretion.Objectives: To determine the safety impact of TLD on respiratory adverse events.Methods: We conducted multicenter, randomized, sham bronchoscopy-controlled, double-blind trial in patients with symptomatic (modified Medical Research Council dyspnea...
<h3>Background</h3> We hypothesised that increased oxidative stress, as present in the airways of asthma and chronic obstructive pulmonary disease (COPD) patients, induces epithelial damage reduces responsiveness to suppressive effects corticosteroids on proinflammatory cytokine production barrier function. <h3>Methods</h3> induced stress by H<sub>2</sub>O<sub>2</sub> and/or cigarette smoke extract (CSE) human bronchial 16HBE cells primary (PBEC) derived brushings from COPD smoking...
<b><i>Background:</i></b> One-way endobronchial valve (EBV) treatment has shown safety and efficacy at 6 months after in patients with severe emphysema confirmed absence of interlobar collateral ventilation. Longer follow-up this subgroup is not available. <b><i>Objectives:</i></b> To investigate the EBV STELVIO cohort a 1-year follow-up. <b><i>Methods:</i></b> Emphysema who have been treated trial were invited for...
For selected patients with advanced emphysema, bronchoscopic lung volume reduction one-way valves can lead to clinically relevant improvements of airflow obstruction, hyperinflation, exercise capacity, and quality life. The most common complication this procedure is pneumothorax a prevalence up ±34% the treated patients. Patients who develop also experience meaningful clinical benefits once resolved. Timely resolution post-valve treatment requires skilled adequate management. This expert...
Target lobar volume reduction (TLVR) is an important efficacy outcome measure for bronchoscopic lung (BLVR) treatment using one-way endobronchial valves (EBV) in patients with severe emphysema. The commonly used cut-off value TLVR that expresses a perceivable clinical benefit -350 mL. However, scientifically determined minimal difference (MID) never has been published. objective of the present study was to determine MID on HRCT who were treated EBV.A total 318 emphysema from two BLVR trials...
Purpose: Lung volume reduction using one-way endobronchial valves is a bronchoscopic treatment for patients with severe emphysema without collateral ventilation between the target lobe and ipsilateral lobe(s). CT-scan fissure analysis often used as surrogate to predict absence of ventilation. We aimed evaluate predictive value completeness score (FCS) compared functional Chartis measurement provide cut-off values FCS in patient selection. Patients Methods: Multicenter study eligible valves....
Background: Endobronchial valve (EBV) treatment is an effective for patients with severe emphysema. Revision bronchoscopies after endobronchial can be essential to prolong the effect of or address long-term complications. Purpose: To evaluate indications, endoscopic findings and outcomes revision investigate if any predictors granulation tissue formation, EBV treatment, identified. Patients Methods: who underwent between 2016 2019 in our hospital, as routine care, were included. If a patient...
Abstract Background Severe chronic obstructive pulmonary disease (COPD) often results in hyperinflation and flattening of the diaphragm. An automated computed tomography (CT)-based tool for quantifying diaphragm configuration, a biomarker COPD, was developed in-house tested large cohort COPD patients. Methods We used LungQ platform to extract lung-diaphragm intersection, as direct segmentation is challenging. The index (surface area/projected surface area) measure configuration on...