A5039090841- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Synthesis and biological activity
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Biosensors and Analytical Detection
- Vitamin C and Antioxidants Research
- Enzyme-mediated dye degradation
- RNA Interference and Gene Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Metal-Catalyzed Oxygenation Mechanisms
- vaccines and immunoinformatics approaches
- Micro and Nano Robotics
- Chemotherapy-induced organ toxicity mitigation
- Molecular Communication and Nanonetworks
- Protein Interaction Studies and Fluorescence Analysis
- Analytical Chemistry and Chromatography
- Electrowetting and Microfluidic Technologies
- Phytochemicals and Medicinal Plants
- Drug Transport and Resistance Mechanisms
- Bioactive Compounds and Antitumor Agents
- Monoclonal and Polyclonal Antibodies Research
Bhavnagar University
2016-2025
Siksha O Anusandhan University
2021
Odisha University of Agriculture and Technology
2021
Bridge University
2021
The new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is the etiological agent of Coronavirus disease 2019 (COVID-19), which becomes an eventual pandemic outbreak. Lack proper therapeutic management has accelerated researchers to repurpose existing drugs with known preclinical and toxicity profiles, can easily enter Phase 3 or 4 be used directly in clinical settings. Vitamins are necessary nutrients for cell growth, function, development. Furthermore, they play important role...
Abstract Background The Transmembrane Serine Protease 2 (TMPRSS2) of human cell plays a significant role in proteolytic cleavage SARS-Cov-2 coronavirus spike protein and subsequent priming to the receptor ACE2. Approaching TMPRSS2 as therapeutic target for inhibition infection is highly promising. Hence, present study, we docked binding efficacy ten naturally available phyto compounds with known anti-viral potential TMPRSS2. aim identify best compound high functional affinity towards active...
Human Papillomavirus (HPV) is a small, non-enveloped, icosahedral and double-stranded DNA virus with genome of 8 kb, belonging to the papillomaviridae family. HPV has been associated 99.7% cases cervical squamous cell carcinoma worldwide. The E6 protein known as potent oncogene closely allied events that result in malignant transformation virally infected cells.The present study aims target plant derived anticancer molecules for driven cancer using computational approach.In this study,...
Imidazolones are potent for their intense antimicrobial and mitigating exercises wherein, an assortment of imidazolone analogs 4-aryl-1-(4-chloro-3-fluorophenyl)-2-phenyl-1H-imidazol-5(4H)-ones (2a-o) 4-aryl-2-phenyl-1-(4-(trifluoromethyl) phenyl)-1H-imidazol-5(4H)-ones (3a-o) were studied amalgamating them by using oxazolones various aryl amines. Newly synthesized compounds screened in vitro activity towards bacterial as well fungal pathogenic microscopic organisms. Among the derivatives,...
Hypoxia, a prevalent characteristic of both solid and liquid malignancies, is found to regulate how genes are expressed in way that promotes cellular adaptability survival. Metastasis controlled by hypoxia-inducible factors (HIFs). HIFs dimeric protein molecules made up an oxygen (O2) responsive HIF-1α, HIF-2α, or HIF-3α domain periodically produced HIF-1β portion (also known as ARNT). Nevertheless, it important note degrade under normoxic conditions. A large multitude different biological...
Abstract The emergence situation of coronavirus disease 2019 (COVID-19) pandemic has realised the global scientific communities to develop strategies for immediate priorities and long-term approaches utilization existing knowledge resources which can be diverted preparedness planning. Lack proper vaccine candidate therapeutic management accelerated researchers repurpose drugs with known preclinical toxicity profiles, easily enter Phase 3 or 4 used directly in clinical settings. We focused...
Abstract Furin, a pro-protein convertase, plays significant role of biological scissor in bacterial, viral, and even mammalian substrates which turn decides the fate many viral bacterial infections along with numerous ailments caused by cancer, diabetes, inflammations, neurological disorders. In wake current pandemic virus SARS COV-2, furin has become center attraction for researchers. present work, we have searched novel inhibitors against this interesting human target from FDA-approved...
Abstract Hypoxia-inducible factor 1 alpha (HIF-1α) is a transcription that regulates the of over 100 genes involved in erythropoiesis, angiogenesis, autophagy, cell survival, and energy metabolism signalling; it appears to be potential target cancer therapy. The aim this study was identify natural compounds from Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target (NPACT) database with anticancer potential. Molecular docking 1574 phytochemicals carried out using Autodock Vina...
Abstract Graphene and graphene oxide (GO) have garnered significant attention due to their exceptional properties. GO, enriched with various functional groups such as epoxy, hydroxyl, carboxylic groups, has exhibited remarkable potential in biomedical applications. The combination of GO metals proven be a promising platform for cellular imaging, this study focusing on the preparation diverse hybrids metal oxides (GO/MO) anticancer agents. In research, is functionalized MOs like TiO 2 , Fe 3...