A5075157553- Silk-based biomaterials and applications
- Biochemical and Structural Characterization
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- Insect and Arachnid Ecology and Behavior
- Silicone and Siloxane Chemistry
- RNA modifications and cancer
- Gastrointestinal disorders and treatments
- RNA and protein synthesis mechanisms
- Advanced Proteomics Techniques and Applications
- Advanced Sensor and Energy Harvesting Materials
- biodegradable polymer synthesis and properties
- Surface Modification and Superhydrophobicity
- Comparative Animal Anatomy Studies
- Insect and Pesticide Research
- Biochemical and Molecular Research
- Plant and animal studies
- Mass Spectrometry Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- Veterinary Equine Medical Research
- Antimicrobial Peptides and Activities
- Epigenetics and DNA Methylation
- Advanced Polymer Synthesis and Characterization
- Synthesis and properties of polymers
- Shoulder Injury and Treatment
Keio University
2016-2025
Keio University Shonan Fujisawa
2015-2025
Nagoya University
2023-2025
Nagahama City Hospital
2018-2022
Institute of Applied Biotechnologies (Czechia)
2019
Tohoku University Hospital
2009-2018
University of Tokyo Hospital
2017
Kureha (Japan)
2008-2013
Kyoto first Red Cross hospital
2013
Tohoku Medical and Pharmaceutical University
2010
Members of the family Araneidae are common orb-weaving spiders, and they produce several types silks throughout their behaviors lives, from reproduction to foraging. Egg sac, prey capture thread, or dragline silk possesses characteristic mechanical properties, its variability makes it a highly attractive material for ecological, evolutional, industrial fields. However, complete set constituents produced by single species is still unclear, novel spidroin genes as well other proteins being...
Significance Artificial synthesis of spider silk has been actively pursued. However, until now, the natural mechanical properties have largely unreproducible. We thoroughly investigated genomes and transcripts four related species orb-weaver spiders as well proteins in their threads. Then, addition to spidroin, we found several low-molecular-weight common. Interestingly, protein component dragline doubled tensile strength artificial silk–based material. This discovery will greatly advance...
Abstract Background Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results treatment failure. Thus, this study aimed to elucidate the underlying mechanisms by which ovarian cancer cells acquire CDDP resistance. Methods We evaluated metabolic profiles CDDP-sensitive A2780 and CDDP-resistant A2780cis using capillary electrophoresis-time-of-flight mass spectrometry (CE-TOFMS). further examined expression of glutamine...
Spider silk is a protein-based material whose toughness suggests possible novel applications. A particularly fascinating example of provided by Darwin's bark spider ( Caerostris darwini ) found in Madagascar. This produces extraordinarily tough silk, with an average 350 MJ m −1 and over 50% extensibility, can build river-bridging webs size 2.8 2 . Recent studies have suggested that specific spidroins expressed C. are responsible for the mechanical properties its silk. Therefore, more...
Abstract To improve the wettability and adhesion, graft polymerization of acrylamide (AAm) glycidyl methacrylate (GMA) was performed onto surface ultra‐high modulus polyethylene (UHMPE) fiber pretreated with Ar plasma. Following plasma treatment subsequent exposure to air introduce peroxides surface, UHMPE allowed proceed from polymer either in deaerated monomer solution at an elevated temperature (degassing method), or aerated containing riboflavin 30°C under UV irradiation (photoinduction...
Abstract Orb-weaving spiders have two main methods of prey capture: cribellate use dry, sticky capture threads, and ecribellate viscid glue droplets. Predation behaviour is a major evolutionary driving force, it important on spider phylogeny whether the each evolved orb architecture independently or both strategies were derived from an ancient web. These hypotheses been discussed based behavioural morphological characteristics, with little discussion this subject perspective molecular...
Extracellular vesicles (EVs) released from cancer cells contribute to various malignant phenotypes of cancer, including metastasis, cachexia, and angiogenesis. Although DNA, mRNAs, miRNAs, proteins contained in EVs have been extensively studied, the function metabolites remains unclear. In this study, we performed a comprehensive metabolomic analysis pancreatic cells, PANC-1, cultured under different oxygen concentrations, small (sEVs) them, considering fact that hypoxia contributes behavior...
The effect of application timing metconazole on the control Fusarium head blight (HFB) and mycotoxin accumulation in wheat barley was investigated. Single double applications at different spray timings were performed a field trial. In single plots, mid-flowering stage optimal for controlling FHB symptom development, milking reducing contamination. Similar efficacies observed all which included another timing. trial, controlled both development contamination with highest efficacy. fungicide....
Sorafenib, an oral multi-kinase inhibitor, is the final therapy prior to palliative care for advanced hepatocellular carcinoma (HCC). However, due its adverse effects, 20% of patients must discontinue sorafenib within 1 month after first administration. To identify ways predict effects and administer drug longer periods, we explored relationship between duration treatment pharmacokinetics major metabolite, N-oxide. Twenty-five subjects enrolled in study were divided into two groups: with...
The sensitivity of the Fusarium graminearum species complex, causal fungus head blight, to metconazole was measured. minimum inhibitory concentrations (MIC) 101 isolates ranged from 0.20 6.25 mg/l with a single peak at 1.56 mg/l. effective concentration for 50% growth inhibition (EC50) <0.1 in about 80% isolates, and no isolate significantly less sensitive among this group. Among F. asiaticum s. str. were identified by PCR-RFLP. trichothecene chemotypes determined as 3ADON, 15ADON, or NIV...
Sorafenib, an oral multi-kinase inhibitor, has been approved for treatment of advanced renal-cell and hepatocellular carcinoma (HCC). However, 20% HCC patients taking sorafenib are forced to withdraw due adverse effects within one month after administration. Orally administered is oxidatively metabolized, predominantly by cytochrome P450 3A4 (CYP3A4), in small-intestinal mucosa or liver. We aimed characterize the CYP3A4-mediated metabolism explore contribution major metabolite N-oxide...
The tardigrade Hypsibius exemplaris can undergo anhydrobiosis. Several chemicals that inhibit successful anhydrobiosis in H. have been identified, and these the activity of signaling molecules. In present study, we investigated whether upregulation molecules could improve desiccation tolerance . Pre‐treatment with an indirect activator AMP‐activated protein kinase [AMPK; which directly inhibits mammalian NAD(P)H dehydrogenase [quinone] 1 [NQO1] mitochondrial complex I (D942)] significantly...
Abstract Tanaidaceans are small benthic crustaceans that mainly inhabit diverse marine environments, and they comprise one of the most abundant macrofaunal groups in deep sea. Tanaidacea is thread-dependent taxa Crustacea, constructing tubes, spun with their silk, for shelter. In this work, we sequenced assembled comprehensive transcriptome 23 tanaidaceans encompassing 14 families 4 superfamilies Tanaidacea, performed silk proteomics Zeuxo ezoensis to search its genes. As a result,...
The effectiveness of object-based classification using high resolution satellite data was examined to establish in applying vegetation mapping. We compared and pixel-based classifiers for secondary forests a rural area the east part Chiba prefecture. minimum distance classifier as classification, maximum likelihood ISODATA were applied. results showed that overall accuracy Kappa statistics higher than those pixel-based, classifications (overall : 64.17%, 60.17%, 53.64% 0.551, 0.497, 0.388,...
Research Articles| June 20 2008 DIE MASSENANTEILE DER EINZELNEN KÖRPERABSCHNITTE JAPANER Subject Area: Further Areas , Pathology and Cell Biology Masaru Mori; Mori Aus dem Anatomischen Institut der Kyushu Universität Fukuoka Vorsteher: Prof. Dr. M. Search for other works by this author on: This Site PubMed Google Scholar Torao Yamamoto Acta Anatomica (1959) 37 (4): 385–388. https://doi.org/10.1159/000141481 Article history Published Online: Content Tools Views Icon contents Figures & tables...