Alper Tunga Özdemir

ORCID: 0000-0002-7708-077X
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About
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Research Areas
  • Mesenchymal stem cell research
  • Immune cells in cancer
  • Reproductive System and Pregnancy
  • Immune Response and Inflammation
  • Adipokines, Inflammation, and Metabolic Diseases
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • IL-33, ST2, and ILC Pathways
  • Cancer Cells and Metastasis
  • Immunotherapy and Immune Responses
  • Cholesterol and Lipid Metabolism
  • Immune Cell Function and Interaction
  • Maternal and fetal healthcare
  • Pregnancy and Medication Impact
  • Cancer, Stress, Anesthesia, and Immune Response
  • CAR-T cell therapy research
  • COVID-19 Impact on Reproduction
  • PARP inhibition in cancer therapy
  • Autoimmune Bullous Skin Diseases
  • Toxin Mechanisms and Immunotoxins
  • Respiratory viral infections research
  • Diet and metabolism studies
  • Eicosanoids and Hypertension Pharmacology
  • Oral health in cancer treatment
  • Cytokine Signaling Pathways and Interactions
  • Rheumatoid Arthritis Research and Therapies

Ege University
2014-2021

Sivas State Hospital
2015-2021

The efficacy of complete blood count parameters in the diagnosis tubal

10.17772/gp/1907 article EN cc-by-nc-nd Ginekologia Polska 2014-01-01

To determine role of human leukocyte antigen (HLA)-G, CD8, CD16, CD56, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α for recurrent miscarriages in feto-maternal interface.Chorion decidua samples were obtained from 11 women with unwanted pregnancies (healthy pregnancy, HP) 10 missed abortion diagnosis after at least two pregnancy losses (recurrent miscarriage, RM). In addition, endometrial tissues non-pregnant (NonP). The expressions markers evaluated using the Western blot analysis....

10.3109/14767058.2015.1114085 article EN The Journal of Maternal-Fetal & Neonatal Medicine 2015-10-29

10.1016/j.plefa.2021.102365 article EN Prostaglandins Leukotrienes and Essential Fatty Acids 2021-10-29

Aim: Mesenchymal stem cells (MSCs) are strong immunomodulatory and a component of the tumor microenvironment. In this study, we aimed to investigate effects MSCs derived from adipose tissue on expressions immune evasive molecules indoleamine 2,3-dioxygenase (IDO), human leukocyte antigen G (HLA-G) programmed death-ligand 1 (PD-L1) breast cell lines MDA-MB-231 MCF-7. Methods: For purpose, MSCs, MCF-7 were cultured with increased doses interferon gamma (IFN-g). another plate, in transwell...

10.25000/acem.601633 article EN ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE 2019-11-29

Objective: The aim of this study is investigation effect glycemic control on the levels malondialdehyde-low-density-lipoprotein-immunglobulin G (MDA-LDL-IgG) which supposed to be positively correlated with myocardial infarction risk in subjects type 2 diabetes mellitus (DM). Material and Method: We evaluated glucose, triglyceride, total cholesterol, high-density-lipoprotein-cholesterol (HDL-C), low-density-lipoprotein-cholesterol (LDL-C), hemoglobin A1c (A1C) MDA-LDL-IgG...

10.17546/msd.91056 article EN Medical Science and Discovery 2015-12-17

Carotid intima-media thickness in postmenopausal women is associated with an endometrial greater than 5 mm Grubość błony środkowej i wewnętrznej tętnicy szyjnej u kobiet po menopauzie jest związana z grubością endometrium większą niż 5mm)DWPD (VNLFLR÷OXï 0XKDPPHW 6DNÕS (VNLFLR÷OXð $OSHU 7XQJD g]GHPLU %H\KDQ g]\XUW

10.17772/gp/61329 article PL cc-by-nc-nd Ginekologia Polska 2016-01-01

The effects of preconditioning with IFN-γ, IL-4, and IL-10 on costimulatory ligand expressions mesenchymal stem cells M esenchymal (MSCs) are powerful immunomodulatory cells.Molecules such as prostaglandin E2 (PGE2), indoleamine-pyrrole 2,3-dioxygenase (IDO), transforming growth factor-beta (TGF-β), interleukin (IL) 10, hepatocyte factor (HGF) play an important role in the formation these [1-3].Molecules cell surface MSCs another mechanism that suppresses immune through contact.Strong...

10.14744/ijmb.2021.77487 article EN cc-by-nc International journal of medical biochemistry/International journal of medical biochemistry : 2021-01-01

Objectives: In this study, it was aimed to investigate the immunomodulatory effects of Mesenchymal stem cells (MSCs) on Natural Killer (NK) activated by Toll-like receptor (TLR) agonists. Methods: MDA-MB-231, MCF-7 and NK-92 were induced with TLR3, TLR7/8 TLR9 agonists co-cultured MSCs. Alterations in IFN-?, TNF-?, Granzyme-b Perforin expressions determined qPCR method, CD69 CD107a flow cytometry, cytotoxicity MTT-assay. Results: All TLR significantly increased Granzyme-b, Perforin,...

10.14744/ejmo.2021.15684 article EN Eurasian Journal of Medicine and Oncology 2021-01-01

Objective: The aim of this study is investigation effect glycemic control on the levels malondialdehyde-low-density-lipoprotein-immunglobulin G (MDA-LDL-IgG) which supposed to be positively correlated with myocardial infarction risk in subjects type 2 diabetes mellitus (DM). Material and Method: We evaluated glucose, triglyceride, total cholesterol, high-density-lipoprotein-cholesterol (HDL-C), low-density-lipoprotein-cholesterol (LDL-C), hemoglobin A1c (A1C) MDA-LDL-IgG well-controlled DM...

10.36472/msd.v3i2.94 article EN Medical Science and Discovery 2016-02-15
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