A5031461736- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Connexins and lens biology
- Neuroendocrine regulation and behavior
- Endometriosis Research and Treatment
- Nerve injury and regeneration
- Testicular diseases and treatments
- Cancer Cells and Metastasis
- Pain Mechanisms and Treatments
- Abdominal Surgery and Complications
- Research on Leishmaniasis Studies
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Advanced Glycation End Products research
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Chemotherapy-induced cardiotoxicity and mitigation
- Renal and related cancers
- Adenosine and Purinergic Signaling
- Pluripotent Stem Cells Research
- Stress Responses and Cortisol
- CRISPR and Genetic Engineering
- Environmental Toxicology and Ecotoxicology
- Cell Adhesion Molecules Research
- Bone health and treatments
Ege University
2015-2024
Ege Üniversitesi Tıp Fakültesi Hastanesi
2018-2021
Rize Devlet Hastanesi
2015
Doxorubicin (DOX) is an anthracycline derivative antibiotic that still frequently used in the treatment of solid tumors and hematological malignancies. The clinical use DOX largely restricted due to acute chronic renal, cardiac, hematological, testicular toxicities. Previous studies have indicated oxidative stress, lipid peroxidation, apoptosis germ cells are main factors DOX-induced toxicity, but entire molecular mechanisms responsible for damage not yet fully understood. Fluvastatin a...
Diabetic peripheral neuropathy (DPN) is widely considered as a degenerative complication of diabetic patients. The clinical effectiveness folic acid (FA) on DPN uncertain. objective the present study was to determine effect FA in using electromyography (EMG), histopathological examination, immunohistochemistry, inclined plane test, and malondialdehyde (MDA) levels marker for lipid peroxidation experimental rats. A total 21 Sprague Dawley rats were randomly divided into 3 groups: control...
Abstract This study investigates the efficacy of cold atmospheric plasma (CAP) in treating squamous cell carcinoma (SCC), a highly metastatic cancer. To assess anticancer activity, two CAP treatment methods—direct and indirect (plasma‐treated N ‐acetyl cysteine solution)—were used. Results indicate that both methods selectively target SCC cells, inducing oxidative nitrosative stress, leading to decreased metabolic activity increased apoptosis. Furthermore, critical feature cancer behavior is...
The aim of the present study was to investigate effects diabetes mellitus (DM) on ovarian reserve and injury by considering laboratory histopathological parameters in rat models. An experimental DM model created 16 rats. Eight rats with normal blood glucose levels were included control group. Diabetic divided randomly into two groups: nontreated resveratrol-treated groups. Histopathological examination nuclear factor (NF)-κB immunoexpression level determination performed. Plasma...
Purpose: The aim of the present study is to investigate protective effects oxytocin (OT) on diabetic neuropathy (DNP) in rats. Materials and methods: Eighteen rats were used induce diabetes using single dose streptozotocin (STZ, 60 mg/kg). Diabetic DNP was verified by electromyography (EMG) motor function test 21st day following STZ injection. Six served as naïve control group received no drug (n = 6). Following EMG, randomly divided into three groups administered with either 1 ml/kg saline...
The aim of the present study was to evaluate effect sunitinib on endometriotic implants and adhesions in a rat endometriosis model. An experimental model created 21 rats. These rats were randomly divided into three groups: Group 1 (control group, 7 rats) given no medication; 2 (sunitinib 3 mg/kg per day oral sunitinib; (danazol 7.2 danazol. volume calculated. extent severity evaluated. groups compared by Student's t-test, analysis variance (ANOVA) Mann–Whitney U test. There statistically...
The aim of this study was to investigate whether prophylactic treatment with edaravone prevents ischemia/reperfusion (I/R)-induced ovarian damage during pneumoperitoneum in an experimental rat model.Twenty-eight female Sprague Dawley rats were allocated randomly 4 groups. sham group (group 1) only subjected catheter insertion, not pneumoperitoneum. Group 2 received a 1 mg/kg dose 0.9% sodium chloride by the intraperitoneal route for 10 min before Groups 3 and 6 12 edaravone, respectively,...
Background: Growth factors such as nerve growth factor (NGF) and insulin-like factor-1 (IGF-1) have been shown to play a role in the healing process of injury.Recent researches also that oxytocin administration activates these importance for tissue.The objective present study was evaluate effects on peripheral regeneration rats.Methods: Twenty-four male Sprague-Dawley rats were underwent transection damage model right sciatic defective left nerve.The animals assigned one two groups: control...
To investigate the potential protective effects of losartan on varicocele-induced germ cell apoptosis, 24 adult male Sprague Dawley rats were divided into three groups: a sham operation was performed in SHAM group, and experimental left varicocele created VAR + LOS groups. Additionally, administered for 30 days starting day surgery. At end days, all animals sacrificed orchiectomy performed. Testicular injury spermatogenesis evaluated according to Johnsen scoring system. assess nitrosative...
To examine and compare the neuroprotective effects of dexamethasone, oxytocin, resveratrol administration on regeneration after facial nerve crush injury in a rat model.Prospective, randomized, controlled animal study.A crush-type was performed right side all rats (injury group [IG]), whereas there no left (sham [SG]). These main groups were divided into five subgroups: 1) medicine (control); 2) physiological serum; 3) dexamethasone; 4) oxytocin; 5) (Res) administered (intraperitoneal...
Doxorubicin (DOXO) is a cytostatic agent used in the chemotherapy protocol of several cancers for more than 40 years, but usage this drug cancer treatment has been limited due to severe renal and cardiac tissue toxicities that may result death patients. Fluvastatin (FV) fully synthetic hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor as cholesterol-lowering patients with hypercholesterolemia. Previous studies revealed FV also exhibits antioxidant, anti-inflammatory, antitumor...
Zinc pyrithione (ZnPT) is one of the components used in antifouling paints and can be an alternative to classical toxic chemicals such as organotin. However, there still remarkable concern about environmental safeness ZnPT due rapid transchelation degradation into several metabolites that have their own toxicity. The effect after acute exposure investigated on Mediterranean mussels exposed 20 40 μg/L concentrations for 48 96 h antioxidant responses [superoxide dismutase (SOD), reduced...
The aim of our study is to investigate the effect sunitinib on diabetes mellitus related-ovarian injury and fibrosis in rat models. An experimental model was created 16 rats, eight rats with normal blood glucose levels were included control group (Group-1). diabetic divided into two groups:diabetic (water given) - Group-2 treatment Group-3. After four weeks, bilateral oophorectomy performed ovaries examined histologically. groups compared by Student's t-test, analysis variance (ANOVA)...
Abstract Embryonic developmental stages and regulations have always been one of the most intriguing aspects science. Since cancer stem cell discovery, striking for development recurrence, embryonic cells control mechanisms, as well mechanisms become important research materials. It is necessary to reveal similarities differences between somatic which are formed divisions determinations. For this purpose, mouse (mESCs), skin fibroblast (MSFs) lung squamous (SqLCCs) were grown in vitro these...