Doxorubicin (DOX) is an anthracycline derivative antibiotic that still frequently used in the treatment of solid tumors and hematological malignancies. The clinical use DOX largely restricted due to acute chronic renal, cardiac, hematological, testicular toxicities. Previous studies have indicated oxidative stress, lipid peroxidation, apoptosis germ cells are main factors DOX-induced toxicity, but entire molecular mechanisms responsible for damage not yet fully understood. Fluvastatin a...

In this study, we investigated the presence of virulence factors in a total 33 Candida parapsilosis strains, including adherence, acid proteinase and phospholipase production capabilities. Of 19 were isolated from blood cultures hospitalised fungaemic patients (study group 2). We also importance other present development fungaemia. The mean adherence values isolates 14 non-blood found to be 52.63 57.96, respectively; these did not differ significantly (P > 0.05). Nine strains (64.29%) study...

Alzheimer's Disease (AD) is a complex neurological condition caused by various factors. Diet, oxidative stress, and the gut microbiota all play critical roles in development of AD. Recent studies suggested bidirectional relationship between brain, emphasizing pivotal role microbiome influencing cognitive functions. For instance, dysbiosis, disruption balance microbial communities, has been linked to neuroinflammation accumulation amyloid-beta plaques, hallmark features Oxidative arising from...

Phthalates are esters of phthalic acid and mainly used as plasticizers in a wide variety products applications. There is no information on butyl cyclohexyl phthalate (BCP) toxicity. This study was performed to evaluate the histopathological effects determine oxidative stress inducing potential liver by subacute exposure BCP. The animals treatment groups were orally administered 100, 200, 400 mg/kg/day BCP for 5 consecutive days per week during 28 days. As result, significant changes observed...

Zinc pyrithione (ZnPT) is one of the components used in antifouling paints and can be an alternative to classical toxic chemicals such as organotin. However, there still remarkable concern about environmental safeness ZnPT due rapid transchelation degradation into several metabolites that have their own toxicity. The effect after acute exposure investigated on Mediterranean mussels exposed 20 40 μg/L concentrations for 48 96 h antioxidant responses [superoxide dismutase (SOD), reduced...

Mesenchymal stem cells (MSCs) derived from bone marrow are a powerful cellular resource and have been used in numerous studies as potential candidates to develop strategies for treating variety of diseases. The purpose this study was characterize MSCs vehicles engineered delivery therapeutic factors part neuroprotective strategy rescuing the damaged or diseased nervous system. In we mouse that were genetically modified using lentiviral vectors, which encoded brain-derived neurotrophic factor...

It is crucial to understand the in vitro and vivo regulation of virulence factor genes bacterial pathogens. In this study, we describe construction a versatile reporter system for Yersinia enterocolitica serotype O:3 (YeO3) based on luxCDABE operon. strain YeO3-luxCDE integrated luciferase substrate biosynthetic genes, luxCDE, into genome bacterium so that constitutively produced. The luxAB encode enzyme were cloned suicide vector allow cloning any promoter-containing fragment upstream...

Losartan, an antihypertensive drug, is highly preferred in patients with diabetes mellitus (DM) and hypertension because of its retarding effect on diabetic nephropathy. In this study, we investigated the potential therapeutic different doses losartan hepatic damage a streptozotocin (STZ, 50 mg/kg)-induced DM model rats.In five groups were formed: control, DM, low-dose (5 mg/kg), mid-dose (20 high-dose (80 mg/kg). Liver tissues experimental evaluated immunohistochemically for TUNEL, iNOS,...

Mesenchymal stem cells (MSCs) derived from bone marrow are a powerful cellular resource and have been used in numerous studies as potential candidates to develop strategies for treating variety of diseases. The purpose this study was characterize MSCs vehicles engineered delivery therapeutic factors part neuroprotective strategy rescuing the damaged or diseased nervous system. In we mouse that were genetically modified using lentiviral vectors, which encoded brain-derived neurotrophic factor...

The aim of this study was to investigate the effects restraint stress and nitric oxide synthase (NOS) inhibition by NωNitro-L-Arginine (LNA) on learning strategy preference.Rats were randomly divided into four groups (Saline, Saline+Stress, LNA, LNA+Stress). Stress applied for one hour in glass cylinders during 13 days. One after application, water maze experiments started. Injections (saline 1 ml/kg or 50 mg/kg LNA) given 10 minutes before each experiment. platform kept visible hidden (on...

Streptozotocin (STZ) is used as a diabetes-inducing agent in experimental animal studies. However, it known that STZ-induced diabetic animals show significant increases oxidative stress parameters and neurodegeneration besides their blood glucose level. In this study, the acute subacute toxic effects of STZ on liver, sciatic nerve, brain tissues were investigated vivo rat model. Sprague-Dawley rats divided into two groups; while 50 mg/kg was administered ip to group, only saline control...