A5011221995- Testicular diseases and treatments
- Cancer, Lipids, and Metabolism
- Spinal Cord Injury Research
- Sperm and Testicular Function
- Chemotherapy-induced cardiotoxicity and mitigation
- Pregnancy-related medical research
- Ovarian function and disorders
- Retinoids in leukemia and cellular processes
- Macrophage Migration Inhibitory Factor
- Ginseng Biological Effects and Applications
- Hormonal and reproductive studies
- Atherosclerosis and Cardiovascular Diseases
- Gastroesophageal reflux and treatments
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- Polyamine Metabolism and Applications
- Childhood Cancer Survivors' Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Bacterial Infections and Vaccines
- Mesenchymal stem cell research
- Reproductive System and Pregnancy
- Autophagy in Disease and Therapy
- Vitamin K Research Studies
- Pancreatic function and diabetes
Harran University
2017-2025
Ege University
2019-2024
Tokat Gaziosmanpaşa Üniversitesi
2013-2016
Doxorubicin (DOX) is an anthracycline derivative antibiotic that still frequently used in the treatment of solid tumors and hematological malignancies. The clinical use DOX largely restricted due to acute chronic renal, cardiac, hematological, testicular toxicities. Previous studies have indicated oxidative stress, lipid peroxidation, apoptosis germ cells are main factors DOX-induced toxicity, but entire molecular mechanisms responsible for damage not yet fully understood. Fluvastatin a...
Spinal cord injury (SCI), which is characterized by motor and/or sensory dysfunction, presents a significant health challenge resulting from mechanical trauma. Secondary injury, follows the trauma and driven factors such as inflammation, plays critical role in SCI pathophysiology. Scientific evidence indicates that treatment strategies aimed at modulating inflammation during acute phase of alleviate seconder injury. In this regard, present study seeks to evaluate effectiveness certolizumab,...
BACKGROUND: Spinal cord injury is a devastating trauma that leaves survivors at risk for several medical complications throughout their lives.Lercanidipine, third-generation calcium channel blocker, possesses anti-apoptotic, anti-inflammatory, and antioxidative properties.This study aimed to evaluate the neuroprotective effects of lercanidipine in an experimental spinal model. METHODS:Twenty-one Wistar rats were randomly assigned three groups.Group 1 (G1) underwent laminectomy.Group 2 (G2)...
Doxorubicin (DOXO) is a cytostatic agent used in the chemotherapy protocol of several cancers for more than 40 years, but usage this drug cancer treatment has been limited due to severe renal and cardiac tissue toxicities that may result death patients. Fluvastatin (FV) fully synthetic hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor as cholesterol-lowering patients with hypercholesterolemia. Previous studies revealed FV also exhibits antioxidant, anti-inflammatory, antitumor...
Abstract Embryonic developmental stages and regulations have always been one of the most intriguing aspects science. Since cancer stem cell discovery, striking for development recurrence, embryonic cells control mechanisms, as well mechanisms become important research materials. It is necessary to reveal similarities differences between somatic which are formed divisions determinations. For this purpose, mouse (mESCs), skin fibroblast (MSFs) lung squamous (SqLCCs) were grown in vitro these...
Diabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, only effective treatments are blood glucose control and pain management. The aim of current study was to determine effect intramuscular adipose-derived mesenchymal stem cell (AMSC) transplantation on sciatic nerves in DN using EMG histological analyses. A total 27 mice were randomly divided into three groups: group, group AMSC group. In EMG, CMAP...
Losartan, an antihypertensive drug, is highly preferred in patients with diabetes mellitus (DM) and hypertension because of its retarding effect on diabetic nephropathy. In this study, we investigated the potential therapeutic different doses losartan hepatic damage a streptozotocin (STZ, 50 mg/kg)-induced DM model rats.In five groups were formed: control, DM, low-dose (5 mg/kg), mid-dose (20 high-dose (80 mg/kg). Liver tissues experimental evaluated immunohistochemically for TUNEL, iNOS,...
Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor regulatory cytokine that inhibits random immune cell migration. MIF gene promoter polymorphisms play role in progression of several disorders.To investigate relationship between -173 G/C single-nucleotide polymorphism (SNP) AS.Cross-sectional study.In this study, total 161 AS 194 normal controls were recruited. The SNP was analyzed by...
Obesity results in a proinflammatory state starting within the metabolic cells as adipocyte, monocyte. The bioactive system, including cytokines IL-4 and IL-6, contributes to pathogenesis of conditions associated with obesity favors inflammation. This study aimed investigate role gene intron 3 VNTR IL-6 - 597G/A polymorphisms obesity. included 127 patients (BMI>30kg/m2) 110 healthy controls. Genomic DNA was isolated genotyped using polymerase chain reaction (PCR) followed by restriction...
Objective:The implantation period of gestation is a complex process in which numerous molecular pathways play role.The Janus kinase/signal transducers and activators transcription (JAK/STAT) pathway one the evolutionarily conserved cascades used to transduce multitude signals for several biological events such as uterine receptivity.Previous studies have indicated that disrupted by lack proteins involved this pathway.However, our literature knowledge showed there no study evaluated...
Hücre davranışı ve farklılaşmasının yanı sıra hücre bölünme modeli de canlılar için hayati önem taşımaktadır. Hücresel farklılaşma çeşitliliği, doğrudan dolaylı olarak erken embriyonik aşamada iskeleti, polaritesi, içi dışı sinyaller gibi biyolojik süreçlerin sıra, şekli hareketinden etkilenir. Atipik davranışı, embriyogenezde bazen onkogenezde gözlenmektedir. trafik, hücrenin dışarıdan gelen sinyallere verdiği cevaplar yönünden daha kapsamlı değerlendirilmelidir. Bu derlemenin amacı:...
Abstract Background: Diabetes mellitus (DM) is common metabolic disease that poses a major risk to public health and fertility. Previous studies indicate DM may cause male infertility by triggering oxidative stress germ cell apoptosis in the testis. Present study aimed investigate possible antiapoptotic effect of losartan against DM-induced testicular apoptosis. Methods Results: Expreimental model was induced intraperitoneal injection streptozocin (STZ, 55 mg/kg) 28 rats, which were then...