Doxorubicin (DOX) is an anthracycline derivative antibiotic that still frequently used in the treatment of solid tumors and hematological malignancies. The clinical use DOX largely restricted due to acute chronic renal, cardiac, hematological, testicular toxicities. Previous studies have indicated oxidative stress, lipid peroxidation, apoptosis germ cells are main factors DOX-induced toxicity, but entire molecular mechanisms responsible for damage not yet fully understood. Fluvastatin a...

Cypermethrin is a synthetic pyrethroid that belongs to group of insecticides with low mammalian toxicity but high insecticidal activity. The present study was undertaken evaluate subacute orally administered cypermethrin in rats based on the haematological, enzymological, and histological brain examination. conducted 8-week old male Wistar Kral 250 EC (250 g cypermethrin/l) (60, 150, 300 mg/kg) for 28 consecutive day. Thus, investigation covered four groups animals: three experimental one...

This study was designed to investigate the possible histological effects of different intranasal (IN) formulations indomethacin (IND) on nasal mucosa in sheep. For this purpose, oil-in-water (O/W) emulsion (E) and solution (S) including 3 mg/mL IND were prepared. Penetration enhancers such as polyvinylpyrolidone (PVP), citric acid (CA) sodium taurocholate (NaT) added (1%) at final step into formulations. First, effect penetration permeation evaluated by vitro studies which sheep used....

Naproxen (Np) is an example of a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction pain and inflammation. In order to develop alternative formulation topical administration Np, microemulsions were evaluated as delivery vehicles. Four formulations prepared using isopropyl myristate (IPM) oil phase, Span 80, Labrafil M, Labrasol, Cremophor EL surfactants, ethanol co-surfactant distilled water or 0.5 N NaOH solution aqueous phase. The final concentration Np in...

Objective: To investigate whether granulocyte-colony stimulating factor (G-CSF) can decrease the extent of ovarian follicle loss caused by cisplatin treatment.Methods: Twenty-one adult female Sprague-Dawley rats were used.Fourteen administered 2 mg/kg/day intraperitoneal injection twice per week for five weeks (total 20 mg/kg).Half (n=7) treated with 1 mL/kg/day physiological saline, and other half 100 µg/kg/day G-CSF.The remaining (n=7, control group) received no therapy.The animals then...

Cypermethrin, a synthetic pyrethroid, has broad-spectrum use in agriculture, domestic and veterinary applications due to its high bioefficacy, enhanced stability considerably low mammalian toxicity. The objective of this study was investigate the cypermetrin-induced alterations liver tissue Wistar male rats, based on histopatological, enzymological analyses apoptotic changes. animals experimental groups were orally fed with laboratory chow combined 60, 150, 300 mg/kg Kral 250 EC during 28...

We aimed to evaluate: (1) endometrial and ovarian tissue injury caused by the glucose toxicity in diabetic rat model (2) effect of GLP-1 analog (exenatide) on diabetes induced with emphasizing underlying mechanism. The study group composed 24 female rats assigned randomly into 3 groups. Group 1 was control (n = 8) received no treatment. Diabetes intraperitoneal injection streptozocin for 16 which are further 2 groups: ml/kg saline given Group-2 (diabetic non-treated group, 8 rats) 10...

Phthalates are esters of phthalic acid and mainly used as plasticizers in a wide variety products applications. There is no information on butyl cyclohexyl phthalate (BCP) toxicity. This study was performed to evaluate the histopathological effects determine oxidative stress inducing potential liver by subacute exposure BCP. The animals treatment groups were orally administered 100, 200, 400 mg/kg/day BCP for 5 consecutive days per week during 28 days. As result, significant changes observed...

<b><i>Aims:</i></b> To evaluate the effect of granulocyte colony-stimulating factor (G-CSF) on endometrium and ovaries in an experimental diabetes mellitus (DM) rat model. <b><i>Methods:</i></b> A total 18 female Sprague-Dawley albino mature rats (8 weeks, 200-220 g) were used this study. Diabetes was induced by intraperitoneal (i.p.) injection streptozocin randomly 12 rats. No drug administered to remainder (control group, group 1, n = 6). The...

The aim of the present study was to investigate effects diabetes mellitus (DM) on ovarian reserve and injury by considering laboratory histopathological parameters in rat models. An experimental DM model created 16 rats. Eight rats with normal blood glucose levels were included control group. Diabetic divided randomly into two groups: nontreated resveratrol-treated groups. Histopathological examination nuclear factor (NF)-κB immunoexpression level determination performed. Plasma...

Purpose: The aim of the present study is to investigate protective effects oxytocin (OT) on diabetic neuropathy (DNP) in rats. Materials and methods: Eighteen rats were used induce diabetes using single dose streptozotocin (STZ, 60 mg/kg). Diabetic DNP was verified by electromyography (EMG) motor function test 21st day following STZ injection. Six served as naïve control group received no drug (n = 6). Following EMG, randomly divided into three groups administered with either 1 ml/kg saline...

The aim of the present study was to evaluate effect sunitinib on endometriotic implants and adhesions in a rat endometriosis model. An experimental model created 21 rats. These rats were randomly divided into three groups: Group 1 (control group, 7 rats) given no medication; 2 (sunitinib 3 mg/kg per day oral sunitinib; (danazol 7.2 danazol. volume calculated. extent severity evaluated. groups compared by Student's t-test, analysis variance (ANOVA) Mann–Whitney U test. There statistically...

Abstract: At present, an intensive effort for prevention of neuroma formation following peripheral nerve section continues. It has been recently suggested that surgical pinealectomy (Px) induces elevation the collagen content in granulation tissue a wound, while melatonin application after Px suppresses accumulation tissue. The aim present study was to assess whether had ability suppress production and transection. A total 40 male rats (four groups 10) were left intact (intact controls) or...

The preservatives benzalkonium chloride (BZC) and potassium sorbate (PS) are widely used in the formulation of nasal drops cosmetics. Recently, a number side effects that resulted from mucosal irritation caused by BZC PS have been reported. Therefore, this study was performed to investigate possible clinical histological alterations induced vivo administration these mucosa rats. 0.01% 0.12% were administered nostrils male rats for 1 or 4 weeks. Clinical symptoms recorded during treatment,...