A5101873873- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Wound Healing and Treatments
- Invertebrate Immune Response Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Malaria Research and Control
- 3D Printing in Biomedical Research
- Microbial Community Ecology and Physiology
- Immune Cell Function and Interaction
- Electrospun Nanofibers in Biomedical Applications
- Power Systems and Renewable Energy
- Power Systems and Technologies
- Smart Grid and Power Systems
- Diamond and Carbon-based Materials Research
- Immunotherapy and Immune Responses
- Insect and Pesticide Research
- Lubricants and Their Additives
- Studies on Chitinases and Chitosanases
- Biochemical Acid Research Studies
- Dengue and Mosquito Control Research
- Metal and Thin Film Mechanics
- Diabetes and associated disorders
- Liver physiology and pathology
Center for Life Sciences
2015-2024
Tsinghua University
2006-2024
Peking University
2012-2024
Wuyi University
2021-2024
Shenzhen Bay Laboratory
2021-2024
Ji Hua Laboratory
2024
Shenzhen Center for Disease Control and Prevention
2019-2024
Wuhan University
2019-2024
Huazhong University of Science and Technology
2024
Peking University Third Hospital
2024
A full understanding of the inactivated COVID-19 vaccine-mediated antibody responses to SARS-CoV-2 circulating variants will inform vaccine effectiveness and vaccination development strategies. Here, we offer insights into vaccine-induced after prime-boost at both polyclonal monoclonal levels. We characterized VDJ sequence 118 antibodies (mAbs) found that 20 neutralizing mAbs showed varied potency breadth against a range including XBB.1.5, BQ.1.1, BN.1. Bispecific (bsAbs) based on...
Abstract Mosquitoes transmit many disease-relevant flaviviruses. Efficient viral transmission to mammalian hosts requires mosquito salivary factors. However, the specific components facilitating and their mechanisms of action remain largely unknown. Here, we show that a female gland-specific protein, here named A. aegypti Neutrophil Recruitment Protein ( Aa NRP), facilitates Zika dengue viruses. NRP promotes rapid influx neutrophils, followed by virus-susceptible myeloid cells toward bite...
We have developed a simple method to fabricate gradient from superhydrophobicity superhydrophilicity. It is based on the controlled self-assembled monolayer consisting of thiol molecule gold surface and amplifying effect wetting property rough surface. Using relatively dilute HS(CH2)11CH3 solution (0.05 mmol/L), we found that density molecules can be by varying immersion time. Slowly adding container holding substrate will lead along After complementary adsorption HS(CH2)10CH2OH, exhibits...
High expression of glutaminyl cyclase (QC) contributes to the initiation Alzheimer's disease (AD) by catalyzing generation neurotoxic pyroglutamate (pE)-modified β-amyloid (Aβ) peptides. Preventing pE-Aβs QC inhibition has been suggested as a novel approach disease-modifying therapy for AD. In this work, series diphenyl conjugated imidazole derivatives (DPCIs) was rationally designed and synthesized. Analogues with scaffold exhibited potent inhibitory activity against human (hQC) good in...
Significance Zika virus (ZIKV) circulated undetectably for decades until its recent outbreak from 2015 to 2017. Our study demonstrated that a mutation in the ZIKV capsid protein (C-T106A) significantly increased epidemic potential of over transmission cycle by promoting efficient assembly virions. results offer additional evidence about evolutionary enhancement infectivity mammalian hosts and mosquitoes, potentially improving our understanding relationships between evolution occasional...
Multifunctional (moisture absorption and retention, antibacterial activity, biocompatibility, adjustable drug release) diabetic wound dressing in coaxial 3D bioprinting.
Public health is confronting the threat caused by antibiotic resistance and this means new antibacterial strategies must be developed urgently. Antimicrobial peptides (AMPs) have been considered as promising therapeutic candidates against infection in post-antibiotic era. In paper, we dismissed significance of "Rana box" natural nigrocin-HL identified from skin secretion Hylarana latouchii comparing its activity with nigrocin-HLD without motif. By substituting sequence an amidated...
Arboviruses are etiological agents of various severe human diseases that place a tremendous burden on global public health and the economy; compounding this issue is fact effective prophylactics therapeutics lacking for most arboviruses. Herein, we identified 2 bacterial lipases secreted by Chromobacterium bacterium isolated from Aedes aegypti midgut, antiviral effector-1 ( Cb AE-1) AE-2, with broad-spectrum virucidal activity against mosquito-borne viruses, such as dengue virus (DENV), Zika...
Hematophagous arthropods, such as mosquitoes, naturally carry and transmit hundreds of arboviruses to humans. Blood meal is a predominant physical interface that shapes cross-species communications among humans, bloodsuckers, arboviruses. Here, we identify human-blood-derived microRNA, hsa-miR-150-5p, interferes with mosquito antiviral system facilitate flavivirus infection transmission. hsa-miR-150-5p acquired blood into the hemocoel persists for prolonged time there. The agomir enhances,...
With the growth of business, an enterprise would like to make its PSC(private storage cloud) approach infrastructure service in a Partner/Public Cloud. In such PSCs, there are some new security issues, First, how isolate data stored PSC from internal and external attackers, Second, secure intra-cloud migration within enterprise, Third, inter-cloud between this paper, we propose architecture enforcing services on layer HDFS, including Data Isolation Service, Secure Intra-Cloud Migration...