A5000872856- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Nuclear Structure and Function
- PARP inhibition in cancer therapy
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- CRISPR and Genetic Engineering
- Renal cell carcinoma treatment
- Cell death mechanisms and regulation
- Skin and Cellular Biology Research
- Congenital limb and hand anomalies
- Renal and related cancers
- Protein Kinase Regulation and GTPase Signaling
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Kruppel-like factors research
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- Endometrial and Cervical Cancer Treatments
- Bone Metabolism and Diseases
Sapienza University of Rome
2013-2024
Università degli Studi Internazionali di Roma
2021
ORCID
2021
University of Bologna
2003-2004
In chronic lymphocytic leukemia, NOTCH1, SF3B1, BIRC3 and TP53 disruptions are recurrent affect survival. To define their incidence clinical impact in patients undergoing first-line treatment, we evaluated 163 cases enrolled the GIMEMA (Gruppo Italiano Malattie EMatologiche dell'Adulto) LLC0405 protocol (fludarabine plus alemtuzumab or fludarabine cyclophosphamide), for young patients, ML21445 (chlorambucil rituximab), elderly patients. were detected 15.9%, 12.2%, 8.6% 10.4% of cases. NOTCH1...
High- and low-risk endometrial carcinoma (EC) differ in whether or not a lymphadenectomy is performed. We aimed to develop MRI-based radio-genomic models able preoperatively assess lymph-vascular space invasion (LVSI) discriminate between low- high-risk EC according the ESMO-ESGO-ESTRO 2020 guidelines, which include molecular risk classification proposed by “ProMisE”. This retrospective, multicentric study that included 64 women with who underwent 3T-MRI before hysterectomy. Radiomics...
Harpagophytum procumbens (Burch.) DC. ex Meisn. is a traditional remedy for osteoarticular diseases, including osteoarthritis (OA), although the bioactive constituents and mechanisms involved are yet to be clarified. In present study, an aqueous H. root extract (HPE; containing 1.2% harpagoside) was characterized its effects on synoviocytes from OA patients phytochemical composition in polyphenols, volatile compounds were detected. HPE powder dissolved different solvents, deionized water...
Minimal residual disease (MRD) is becoming increasingly important in chronic lymphocytic leukaemia (CLL) as treatment strategies are progressively improving. The primary objective of this study was to compare the applicability three different flow cytometric approaches: basic 4-colour analysis, European Research Initiative CLL (ERIC) consensus method and 8-colour analysis. Secondly, we investigated sensitivity specificity cytometry (FC) compared molecular analyses for MRD detection. A total...
To assess the involvement of microRNAs (miRNAs) in B‐cell receptor (BCR) stimulation, we first evaluated miRNA profiling following IgM cross‐linking chronic lymphocytic leukemia (CLL) cells and normal B lymphocytes. Second, combined gene expression data to identify putative functional networks. showed distinctive patterns regulation after stimulation leukemic versus lymphocytes identified a differential responsiveness BCR engagement CLL subgroups according immunoglobulin heavy chain variable...
A comprehensive panel of clinical-biological parameters was prospectively evaluated at presentation in 112 patients with chronic lymphocytic leukemia (<65 years), to predict the risk progression early stage disease.Eighty-one percent were Binet A, 19% stages B/C.Treatment-free survival as time from diagnosis first treatment, death or last follow up.In univariate analysis, advanced stage, hemoglobin, platelets, white blood cell, leukemic lymphocyte count, raised beta 2-microglobulin and LDH,...
Summary Whole exome sequencing and copy number aberration ( CNA ) analysis were performed on cells taken from peripheral blood PB lymph nodes LN of patients with chronic lymphocytic leukaemia CLL ). Of 64 non‐silent somatic mutations, 54 (84·4%) clonal in both compartments, 3 (4·7%) ‐specific 7 (10·9%) ‐specific. Most the ‐ or mutations subclonal other corresponding compartment (variant frequency 0·5–5·3%). 41 s, 27 (65·8%) shared by compartments (17·1%) Overall, 6 9 cases (66·7%) showed...
SMYD3 is frequently overexpressed in a wide variety of cancers. Indeed, its inactivation reduces tumor growth preclinical vivo animal models. However, extensive characterization vitro failed to clarify function cancer cells, although confirming importance carcinogenesis. Taking advantage mutant variant identified high-risk breast family, here we show that phosphorylation by ATM enables the formation multiprotein complex including ATM, SMYD3, CHK2, and BRCA2, which required for final loading...
We investigated whether the combination of an angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor antagonist offers better control proteinuria cardiovascular parameters without causing adverse side effects.We enrolled 10 children (mean age: 12.3 +/- 4.06 years) with resulting from chronic renal diseases various causes. The study consisted 2 phases, 3 months each, for overall 6-month observation time. During phase (3 months), each child was assigned randomly to...
We analyzed TP53 mutations in 483 chronic lymphocytic leukemia patients at different phases of the disease and found a higher incidence later distinctive mutation profile each phase. p53 function evaluated by immunoblotting flow cytometry after cell irradiation was impaired 28 109 cases. Three phenotypically dysfunctions were observed: type I, associated with heterozygous missense (typically present diagnosis) partially resistant to radiation-induced killing; types II III, microdeletions,...
The definition of the number and nature signal transduction pathways involved in pathogenesis identification molecules promoting metastasis spread might improve knowledge natural history osteosarcoma, also allowing refine prognosis opening way to novel therapeutic strategies. Phosphatydil inositol (4,5) bisphosphate (PIP2), belonging Phosphoinositide (PI) pathway, was related regulation ezrin, an ezrin-radixin-moesin protein metastatic osteosarcoma spread. levels PIP2 are regulated by means...
Abstract Background The network of intermediate filament proteins underlying the inner nuclear membrane forms lamina. Lamins have been associated with important cellular functions: DNA replication, chromatin organization, differentiation cell, apoptosis and in maintenance structure. Little is known regarding etiopathogenesis adhesive capsulitis (AC); recently, a dysregulating fibrotic response starting from subpopulation has described within fibroblast compartment, which suddenly turns on an...
Systemic Lupus Erythematosus (SLE) often causes damage to small nerve fibers, leading distressing painful and autonomic symptoms. Despite this, Small Fiber Neuropathy (SFN) remains an underrecognized complication for SLE patients. In this cross-sectional study, we aimed assess SFN in patients with explore its correlations immunologic disease features clinical manifestations.
The network of intermediate filament proteins underlying the inner nuclear membrane forms lamin. A- and B-type lamins are major components lamina. Lamins function in many activities. role lamin A transcription factors (NF-kB) as anti-apoptotic is well documented. Recently, has also been considered a mechanosensor protein that able to maintain integrity from mechanical insults. We aimed verify how expression varies healthy cuff cells those with different-sized tears where various stresses...
The ultraviolet (UV) component of solar radiation is the driving force life on earth, but it can cause photoaging and skin cancer. In this study, we investigated effects glucosamine-derivative 2-(N-Acetyl)-L-phenylalanylamido-2-deoxy-β-D-glucose (NAPA) human primary fibroblasts (FBs) stimulated in vitro with environmental levels UVB radiation. FBs were irradiated 0.04 J cm-2 dose, which resulted a mild dosage as shown by cell viability ROS production measurement. This dose induced activation...
In a limited study, comprising only ten patients, we have previously reported that allogeneic irradiated RCC-cell-line cells, engineered to produce IL-2 (ACHN-IL-2), admixed with autologous metastatic formalin-treated tumour cells were used vaccinate MRCC patients in progression of disease and also receiving immunotherapy. The TC, administered subcutaneously. We now report an extended study on thirty one hundred thirty-one controls. Patients received 4ñ20 injections (mean 10 ± 4), containing...
Abstract The phosphoinositide (PI) signal transduction pathway participates in liver metabolism. Abnormal activity or expression of PI‐specific phospholipase C (PLC) enzymes has been described different diseases. We resume the role PI metabolism and PLC abnormalities Moreover, we present results analyses a normal human an alcohol‐damaged liver. corresponding genes biopsies from individuals deceased for complications alcoholic disease (ALD) at stages compared with controls (deceased...
Supernatants From Human Osteosarcoma Cultured Cell Lines Induce Modifications in Growth and Differentiation of THP-1 Cells Phosphoinositide- Specific Phospholipase C Enzymes